| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Collaboration revenue: | ||||||||||||
Collaboration revenue from customers | ||||||||||||
0 | 26,678 | 147,588 | 135,179 | 0 | 129,160 | 3,484 | 2,289 | 0 | - | 0 | 0 | - |
Other collaboration revenue | ||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Operating expenses: | ||||||||||||
Research and development | ||||||||||||
206,995 | 193,382 | 181,740 | 159,517 | 159,767 | 143,183 | 121,745 | 109,939 | 76,809 | 74,460 | 0 | 0 | 0 |
General and administrative | ||||||||||||
49,725 | 46,480 | 46,646 | 44,269 | 36,089 | 32,349 | 26,373 | 21,308 | 17,976 | 15,680 | 0 | 0 | 0 |
Total operating expenses | ||||||||||||
256,720 | 239,862 | 228,386 | 203,786 | 195,856 | 175,532 | 148,118 | 131,247 | 94,785 | 90,140 | 0 | 0 | 0 |
Loss from operations | ||||||||||||
-230,643 | -213,184 | -80,704 | -68,513 | -63,132 | -46,372 | -144,634 | -128,958 | -94,144 | -90,140 | 0 | 0 | 0 |
Interest and other income, net | ||||||||||||
14,772 | 15,219 | 14,222 | 13,033 | 11,578 | 10,132 | 7,974 | 5,825 | 3,601 | 1,955 | 0 | 0 | 0 |
Loss before income taxes | ||||||||||||
-215,871 | -197,965 | -179,386 | -187,737 | 0 | - | 0 | 0 | - | - | - | - | - |
Income tax benefit | ||||||||||||
-500 | -400 | -400 | -300 | 0 | - | 0 | 0 | - | - | - | - | - |
Net loss | ||||||||||||
-215,385 | -197,614 | -66,056 | -55,167 | -51,554 | -36,240 | -136,660 | -123,133 | -90,543 | -88,185 | 0 | 0 | 0 |
Other comprehensive income (loss): | ||||||||||||
Net unrealized gain on marketable securities, net of tax | ||||||||||||
503 | 999 | 1,978 | 2,372 | 1,619 | -281 | -1,179 | -1,116 | -892 | 5 | 0 | 0 | 0 |
Comprehensive loss | ||||||||||||
-214,882 | -196,615 | -64,078 | -52,795 | -49,935 | -36,521 | -137,839 | -124,249 | -91,435 | -88,180 | 0 | 0 | 0 |
Net loss per share, basic and diluted (usd per share) | ||||||||||||
-0.55 | -0.57 | -0.48 | -0.61 | -0.41 | 0.84 | -0.38 | -0.59 | -0.26 | 0.90 | -2.14 | -2.29 | -2.36 |
Weighted average number of shares outstanding, basic and diluted (in shares) | ||||||||||||
102,419 | 96,093 | 95,859 | 95,495 | 94,984 | 94,362 | 93,665 | 92,899 | 89,560 | 30,937 | 10,231 | 9,670 | 9,017 |