| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Total revenues | ||||||||||
29,564 | 18,564 | 49,170 | 14,025 | - | - | - | - | - | - | - |
Collaborative research and development and other revenue | ||||||||||
- | - | - | - | 7,832 | 8,256 | 3,590 | 42,494 | 22,360 | 20,091 | 12,347 |
Product revenue, net | ||||||||||
- | - | - | - | 11,292 | 11,145 | 11,736 | 10,576 | 11,127 | 11,500 | 12,113 |
Total revenues | ||||||||||
- | - | - | - | 19,124 | 19,401 | 15,326 | 53,070 | 33,487 | 31,591 | 24,460 |
Operating expenses: | ||||||||||
Cost of product revenues | ||||||||||
4,143 | 4,263 | 6,633 | 5,290 | - | - | - | - | - | - | - |
Cost of product revenues | ||||||||||
- | - | - | - | 3,905 | 5,686 | 4,837 | 4,654 | 4,713 | 4,275 | 5,311 |
Research and development | ||||||||||
30,209 | 25,501 | 31,609 | 29,274 | 24,317 | 22,429 | 18,945 | 20,265 | 34,053 | 36,214 | 34,801 |
Selling, general and administrative | ||||||||||
14,363 | 12,419 | 13,165 | 11,825 | 11,566 | 12,284 | 12,706 | 12,095 | 13,574 | 14,937 | 15,020 |
Total operating expenses | ||||||||||
48,715 | 42,183 | 51,407 | 46,389 | 39,788 | 40,399 | 36,488 | 37,014 | 52,340 | 55,426 | 55,132 |
Loss from operations | ||||||||||
-19,151 | -23,619 | -2,237 | -32,364 | -20,664 | -20,998 | -21,162 | 16,056 | -18,853 | -23,835 | -30,672 |
Other income (expense): | ||||||||||
Interest and other income | ||||||||||
1,074 | 870 | 967 | 143 | 237 | 39 | - | - | - | - | - |
Interest and other income (expenses), net | ||||||||||
- | - | - | - | - | - | - | - | 93 | - | - |
Interest expense | ||||||||||
2,501 | 2,573 | 2,425 | 2,288 | 2,236 | 1,151 | 6 | 7 | 5 | - | - |
Interest and other income | ||||||||||
- | - | - | - | - | - | - | - | - | 943 | 420 |
Interest and other expense | ||||||||||
- | - | - | - | - | - | - | - | - | 6 | 36 |
Net other expense | ||||||||||
-1,427 | -1,703 | -1,458 | -2,145 | -1,999 | -1,112 | -290 | 144 | 88 | 937 | 384 |
Net other expense | ||||||||||
- | - | - | - | - | - | -284 | 151 | - | - | - |
Net loss | ||||||||||
-20,578 | -25,322 | -3,695 | -34,509 | -22,663 | -22,110 | -21,452 | 16,200 | -18,765 | -22,898 | -30,288 |
Net change in unrealized loss on available-for-sale securities, net of reclassification adjustments and taxes | ||||||||||
-3 | 1 | 2 | 11 | -101 | 86 | -5 | - | - | - | - |
Net change in unrealized gain (loss) on available-for-sale securities, net of tax | ||||||||||
- | - | - | - | - | - | - | 1 | -1 | -4 | - |
Total comprehensive loss | ||||||||||
-20,581 | -25,321 | -3,693 | -34,498 | -22,764 | -22,024 | -21,457 | 16,201 | - | - | - |
Total comprehensive income (loss) | ||||||||||
- | - | - | - | - | - | - | - | -18,766 | -22,902 | - |
Net loss per share | ||||||||||
Basic | ||||||||||
-0.12 | -0.16 | -0.03 | -0.26 | -0.19 | -0.20 | -0.21 | 0.18 | -0.21 | -0.26 | - |
Diluted | ||||||||||
-0.12 | -0.16 | -0.03 | -0.26 | -0.19 | -0.20 | -0.21 | 0.18 | -0.21 | -0.26 | - |
Weighted-average shares used in computing net loss per share | ||||||||||
Basic | ||||||||||
178,042 | 159,834 | 145,273 | 133,163 | 118,523 | 111,666 | 103,078 | 88,433 | 87,410 | 86,868 | - |
Diluted | ||||||||||
178,042 | 159,834 | 145,273 | 133,163 | 118,523 | 111,666 | 103,078 | 88,589 | 87,410 | 86,868 | - |
Net loss per share, basic and diluted | ||||||||||
- | - | - | - | - | - | - | - | - | - | -0.36 |
Shares used in computing basic and diluted net loss per share | ||||||||||
- | - | - | - | - | - | - | - | - | - | 83,427 |
Collaborative Research and Development and Other Revenue [Member] | ||||||||||
Total revenues | ||||||||||
18,129 | 8,207 | 23,577 | 1,880 | - | - | - | - | - | - | - |
Product Revenue, Net [Member] | ||||||||||
Total revenues | ||||||||||
11,435 | 10,357 | 13,093 | 12,145 | - | - | - | - | - | - | - |
Revenue From Sale of Intellectual Property Rights [Member] | ||||||||||
Total revenues | ||||||||||
- | - | 12,500 | - | - | - | - | - | - | - | - |