| Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||
Net loss | ||||||||
-55,064 | -43,887 | -41,269 | 5,459 | -18,032 | -17,291 | -40,531 | -20,092 | -17,005 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||
Depreciation | ||||||||
922 | 919 | 886 | 857 | 674 | 358 | 262 | 260 | 231 |
Stock-based compensation | ||||||||
4,170 | 9,322 | 6,920 | 8,025 | 6,059 | 3,022 | 1,960 | 523 | 381 |
Acquired in-process research and development | ||||||||
16,539 | 0 | 0 | - | - | - | - | - | - |
Loss (gain) on disposal of property and equipment | ||||||||
-106 | 0 | -10 | 6 | -1 | -6 | -20 | 0 | -3 |
Loss on extinguishment of debt | ||||||||
- | - | - | - | - | -992 | 0 | -144 | - |
Accretion of bond premium | ||||||||
-161 | 395 | 1,310 | 1,615 | 1,246 | 961 | 343 | -3 | -17 |
Net realized foreign currency translation loss | ||||||||
0 | 0 | -51 | 0 | 0 | - | - | - | - |
Non cash interest expense | ||||||||
- | - | - | - | - | 73 | 646 | 160 | 210 |
Change in operating assets and liabilities: | ||||||||
Receivables | ||||||||
-1 | -191 | -856 | -5,490 | 2,508 | 1,409 | 0 | - | - |
Decrease in fair value on preferred stock warrants | ||||||||
- | - | - | - | - | - | - | 237 | 74 |
Extinguishment of liability | ||||||||
- | - | - | - | - | - | - | 18 | - |
Receivables | ||||||||
- | - | - | - | - | - | - | 0 | - |
Prepaid expenses and other assets | ||||||||
-915 | 517 | 96 | -2,711 | -2,016 | 1,287 | -932 | 2,323 | -269 |
Accounts payable | ||||||||
-1,025 | -252 | -60 | -3,700 | -386 | 524 | 943 | -118 | 493 |
Accrued wages, benefits and other liabilities | ||||||||
-13 | -771 | -777 | -2,923 | 1,337 | 3,483 | 838 | 922 | 109 |
Deferred revenue | ||||||||
-50 | -50 | -50 | -59,746 | -41,488 | 99,757 | 0 | 0 | - |
Net cash used in operating activities | ||||||||
-33,658 | -34,650 | -32,218 | -42,205 | -51,080 | 89,191 | -34,584 | -20,745 | -15,396 |
Investing activities | ||||||||
Purchases of property and equipment | ||||||||
82 | 713 | 341 | 1,501 | 827 | 1,862 | 234 | 200 | 155 |
Proceeds from disposal of property and equipment | ||||||||
15 | 0 | 0 | 10 | 0 | 0 | - | - | - |
Purchases of investments | ||||||||
106,724 | 139,932 | 86,281 | 149,370 | 125,026 | 265,203 | 236,930 | 12,295 | 35,496 |
Purchase of acquired in-process research and development | ||||||||
12,770 | 0 | 0 | - | - | - | - | - | - |
Proceeds from sale and maturities of investments | ||||||||
134,930 | 190,765 | 88,114 | 82,302 | 195,146 | 163,671 | 169,853 | 27,507 | 33,785 |
Proceeds from issuance of convertible preferred stock, net of issuance costs | ||||||||
- | - | - | - | - | - | - | - | 26,602 |
Proceeds from borrowings, net of issuance costs | ||||||||
- | - | - | - | - | - | - | 14,857 | - |
Proceeds from issuance of subordinated convertible notes, net of issuance costs | ||||||||
- | - | - | - | - | - | 3,590 | 8,040 | - |
Principal payments on borrowings | ||||||||
- | - | - | - | - | 13,544 | 2,708 | 9,137 | 5,518 |
Proceeds from third public offering, net of issuance costs | ||||||||
- | - | - | - | - | 0 | - | - | - |
Proceeds from second public offering, net of issuance costs | ||||||||
- | - | - | - | - | - | 66,734 | 0 | - |
Net cash provided by (used in) investing activities | ||||||||
15,367 | 50,118 | 1,490 | -68,560 | 69,292 | -103,395 | -67,311 | 15,010 | -1,866 |
Stock repurchase | ||||||||
94 | 164 | 57 | 3 | 0 | 0 | - | - | - |
Proceeds from exercise of warrant to purchase common stock | ||||||||
4,556 | 0 | 0 | - | - | - | - | - | - |
Proceeds from issuance of common stock in connection with equity offering | ||||||||
- | - | - | 101,904 | 0 | - | - | - | - |
Proceeds from the exercise of stock options | ||||||||
1,087 | 261 | 379 | 1,290 | 644 | 391 | 595 | 147 | - |
Proceeds from stock purchases under employee stock purchase plan | ||||||||
72 | 231 | 305 | 299 | 0 | 0 | 78,167 | 0 | - |
Net cash provided by financing activities | ||||||||
5,621 | 328 | 627 | 103,491 | 644 | -13,152 | 146,381 | 13,907 | 21,083 |
Effect of exchange rate | ||||||||
0 | 0 | -1 | -38 | -6 | 0 | -5 | 0 | - |
Net increase (decrease) in cash and cash equivalents | ||||||||
-12,669 | 15,796 | -30,101 | -7,313 | 18,850 | -27,355 | 44,479 | 8,173 | 3,820 |