| Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 | Dec'13 | Sep'13 | Jun'13 | Mar'13 | Dec'12 | Sep'12 | Jun'12 | Mar'12 | Dec'11 | Sep'11 | Jun'11 | Mar'11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||||||||||||||||||||||||
Net loss | ||||||||||||||||||||||||||||||
-41,338 | -51,998 | -52,178 | -55,064 | -57,564 | -43,005 | -45,223 | -43,887 | -42,616 | -43,911 | -40,552 | -41,269 | -39,556 | -35,229 | -2,268 | 5,459 | 10,637 | 13,271 | -17,312 | -18,032 | -15,978 | -14,177 | -11,383 | -17,291 | -27,197 | -38,027 | -43,113 | -40,531 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||||||||||||||||
Depreciation | ||||||||||||||||||||||||||||||
819 | 855 | 886 | 922 | 941 | 944 | 940 | 919 | 900 | 888 | 880 | 886 | 893 | 889 | 879 | 857 | 815 | 773 | 731 | 674 | 603 | 525 | 434 | 358 | 306 | 276 | 263 | 262 | 0 | 0 | 0 |
Stock-based compensation | ||||||||||||||||||||||||||||||
5,940 | 5,010 | 4,393 | 4,170 | 4,113 | 4,733 | 8,370 | 9,322 | 9,589 | 9,935 | 7,324 | 6,920 | 6,989 | 6,854 | 7,457 | 8,025 | 7,910 | 8,093 | 7,161 | 6,059 | 5,180 | 4,186 | 3,388 | 3,022 | 2,863 | 2,688 | 2,556 | 1,960 | 0 | 0 | 0 |
Loss (gain) on disposal of property and equipment | ||||||||||||||||||||||||||||||
13 | 56 | -102 | -106 | 0 | 0 | 0 | - | - | - | - | -10 | 17 | 7 | 7 | 6 | -3 | -2 | -4 | -1 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Amortization of debt discount | ||||||||||||||||||||||||||||||
0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Accretion of bond premium | ||||||||||||||||||||||||||||||
- | - | - | -161 | 64 | 173 | 242 | 395 | 614 | 864 | 1,167 | 1,310 | 1,332 | 1,512 | 1,612 | 1,615 | 1,661 | 1,522 | 1,309 | 1,246 | 1,292 | 1,324 | 1,225 | 961 | 717 | 407 | 323 | 343 | 0 | 0 | 0 |
Non cash interest expense | ||||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -3 | 73 | 118 | 248 | 395 | 646 | 0 | 0 | 0 |
Change in operating assets and liabilities: | ||||||||||||||||||||||||||||||
Receivables | ||||||||||||||||||||||||||||||
-68 | 25 | -156 | -1 | -178 | -124 | -205 | -191 | -200 | -373 | -146 | -856 | -4,094 | -5,453 | -6,082 | -5,490 | 6,081 | 4,930 | 3,941 | 2,508 | -10,124 | -1,624 | -149 | 1,409 | 0 | 0 | 0 | - | - | - | - |
Accrued interest receivable | ||||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | - | - | - | - |
Accounts and accrued interest receivable | ||||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 |
Prepaid expenses and other assets | ||||||||||||||||||||||||||||||
8,253 | 2,169 | -181 | -915 | -743 | -432 | 24 | 517 | 138 | -350 | -346 | 96 | 79 | -439 | -3,503 | -2,711 | -3,122 | -3,204 | -746 | -2,016 | -263 | -97 | 359 | 1,287 | 463 | 786 | 1,565 | -932 | 0 | 0 | 0 |
Accounts payable | ||||||||||||||||||||||||||||||
692 | -420 | -158 | -1,025 | -1,517 | -215 | 290 | -252 | 464 | -450 | -810 | -60 | -123 | -1,697 | -1,940 | -3,700 | -3,993 | -1,409 | -320 | -386 | 623 | 534 | -1,163 | 524 | -848 | -958 | 61 | 943 | 0 | 0 | 0 |
Accrued wages, benefits and other liabilities | ||||||||||||||||||||||||||||||
3,010 | 499 | -354 | -13 | 528 | 798 | 248 | -771 | -1,477 | -791 | -827 | -777 | -3,785 | -7,911 | -4,401 | -2,923 | 478 | 3,822 | 818 | 1,337 | 2,421 | 5,161 | 4,426 | 3,483 | 1,251 | -950 | 46 | 838 | 0 | 0 | 0 |
Deferred revenue | ||||||||||||||||||||||||||||||
-60 | -56 | -53 | -50 | -50 | -50 | -50 | -50 | -50 | -50 | -50 | -50 | -50 | -50 | -46,588 | -59,746 | -62,228 | -75,214 | -41,661 | -41,488 | -48,467 | -43,249 | 86,759 | 99,757 | 0 | 0 | 0 | - | - | - | - |
Net cash used in operating activities | ||||||||||||||||||||||||||||||
-40,533 | -32,626 | -30,880 | -33,658 | -35,955 | -35,921 | -34,997 | -34,650 | -32,459 | -32,728 | -32,314 | -32,218 | -30,275 | -29,735 | -35,660 | -42,205 | -47,672 | -50,862 | -52,462 | -51,080 | -43,929 | -39,141 | 84,114 | 89,191 | 81,248 | 76,367 | -40,556 | -34,584 | 0 | 0 | 0 |
Investing activities | ||||||||||||||||||||||||||||||
Purchases of property and equipment | ||||||||||||||||||||||||||||||
78 | 53 | 58 | 82 | 95 | 291 | 707 | 713 | 750 | 713 | 332 | 341 | 363 | 658 | 880 | 1,501 | 1,574 | 1,293 | 1,416 | 827 | 883 | 1,650 | 1,763 | 1,862 | 1,662 | 878 | 394 | 234 | 0 | 0 | 0 |
Proceeds from disposal of property and equipment | ||||||||||||||||||||||||||||||
0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Purchases of investments | ||||||||||||||||||||||||||||||
363,412 | 197,276 | 119,450 | 106,724 | 76,349 | 71,480 | 113,057 | 139,932 | 149,435 | 140,488 | 95,021 | 86,281 | 84,011 | 71,976 | 167,411 | 149,370 | 133,009 | 149,687 | 86,213 | 125,026 | 130,990 | 171,758 | 276,342 | 265,203 | 286,705 | 266,558 | 168,419 | 236,930 | 0 | 0 | 0 |
Proceeds from sale and maturities of investments | ||||||||||||||||||||||||||||||
143,800 | 109,800 | 130,430 | 134,930 | 132,330 | 145,730 | 142,000 | 190,765 | 186,080 | 172,212 | 138,216 | 88,114 | 96,030 | 97,579 | 96,924 | 82,302 | 76,688 | 66,189 | 136,106 | 195,146 | 189,704 | 209,650 | 141,338 | 163,671 | 190,293 | 175,422 | 233,268 | 169,853 | 0 | 0 | 0 |
Proceeds from issuance of subordinated convertible notes, net of issuance costs | ||||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 3,590 | 0 | 0 | 0 |
Net cash provided by (used in) investing activities | ||||||||||||||||||||||||||||||
-220,033 | -100,195 | -1,787 | 15,367 | 43,562 | 73,958 | 28,235 | 50,118 | 35,893 | 31,011 | 42,863 | 1,490 | 11,665 | 24,954 | -71,357 | -68,560 | -57,895 | -84,790 | 48,476 | 69,292 | 57,830 | 36,240 | -136,766 | -103,395 | -98,075 | -92,014 | 64,454 | -67,311 | 0 | 0 | 0 |
Stock repurchase | ||||||||||||||||||||||||||||||
104 | 104 | 106 | 94 | 100 | 100 | 148 | 164 | 158 | 158 | 108 | 57 | 57 | 61 | 61 | 3 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Proceeds from issuance of common stock in connection with equity offering | ||||||||||||||||||||||||||||||
0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Proceeds from the exercise of stock options | ||||||||||||||||||||||||||||||
10,816 | 7,466 | 3,374 | 1,087 | 241 | 261 | 183 | 261 | 168 | 155 | 174 | 379 | 838 | 1,043 | 1,297 | 1,290 | 825 | 922 | 815 | 644 | 635 | 485 | 398 | 391 | 460 | 762 | 693 | 595 | 0 | 0 | 0 |
Proceeds from stock purchases under employee stock purchase plan | ||||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 78,167 | 0 | 0 | 0 |
Net cash provided by financing activities | ||||||||||||||||||||||||||||||
280,656 | 92,937 | 88,838 | 5,621 | 4,839 | 303 | 266 | 328 | 283 | 270 | 370 | 627 | 1,059 | 1,260 | 103,440 | 103,491 | 102,917 | 103,018 | 815 | 644 | 635 | 485 | -13,145 | -13,152 | -13,083 | 52,582 | 64,720 | 146,381 | 0 | 0 | 0 |
Effect of exchange rate | ||||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | -1 | -5 | -11 | -38 | -38 | -23 | -14 | -6 | -6 | -19 | -21 | -0 | 0 | 0 | 0 | 0 | - | - | - | - |
Net increase (decrease) in cash and cash equivalents | ||||||||||||||||||||||||||||||
- | - | 56,170 | - | - | - | -6,496 | 15,796 | 3,717 | -1,447 | 10,918 | -30,101 | -17,557 | -3,532 | -3,616 | -7,313 | -2,673 | -32,647 | -3,177 | 18,850 | 14,517 | -2,437 | -65,799 | -27,355 | -29,912 | 36,930 | 88,614 | 44,479 | 0 | 0 | 0 |