| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | |
|---|---|---|---|---|---|---|
Cash flow from operating activities | ||||||
Net loss | ||||||
-133,746 | -109,954 | -120,324 | -97,183 | -72,900 | -13,685 | |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Stock-based compensation expense | ||||||
27,243 | 26,598 | 23,364 | 16,881 | 3,513 | 55 | |
Depreciation | ||||||
2,800 | 3,300 | 2,700 | 1,202 | 471 | 157 | |
Non-cash research and development expenses | ||||||
- | 14,442 | 14,500 | 10,000 | - | 730 | |
Non-cash investment in equity securities | ||||||
- | 3,667 | - | - | - | - | |
Re-measurement of warrant to purchase redeemable securities | ||||||
- | - | - | 87 | 241 | -2 | |
Change in fair value of preferred stock tranche asset or liability | ||||||
- | - | - | - | 35,551 | 938 | |
Changes in fair value of anti-dilutive protection liability | ||||||
- | - | - | - | 1,609 | 5 | |
Changes in deferred rent | ||||||
- | - | - | - | - | 184 | |
Other non-cash items, net | ||||||
2,928 | 3,268 | 300 | -869 | -53 | -19 | |
Changes in operating assets and liabilities: | ||||||
Accounts receivable | ||||||
388 | -649 | 591 | -931 | 1,019 | - | |
Prepaid expenses and other current assets | ||||||
495 | 3,410 | 596 | 1,306 | 373 | 88 | |
Right-of-use assets | ||||||
9,300 | - | - | - | - | - | |
Other non-current assets | ||||||
15 | 92 | -2 | -2,246 | - | 20 | |
Accounts payable | ||||||
274 | 1,780 | -1,515 | 3,251 | -1,436 | 2,191 | |
Accrued expenses | ||||||
9,485 | 4,042 | -8,334 | 11,841 | 3,526 | 861 | |
Deferred revenue | ||||||
55,395 | 22,889 | 81,707 | 935 | 25,321 | - | |
Operating lease liabilities | ||||||
9,324 | - | - | - | - | - | |
Other current and non-current liabilities | ||||||
1,652 | 1,030 | -13 | - | - | - | |
Net cash used in operating activities | ||||||
-40,669 | -45,707 | -9,417 | -50,246 | -5,443 | -8,655 | |
Purchases of property and equipment | ||||||
6,167 | 4,754 | 2,059 | 3,493 | 1,431 | 1,217 | |
Proceeds from the sale of equipment | ||||||
102 | 37 | 15 | 20 | - | - | |
Purchases of marketable securities | ||||||
342,183 | 459,370 | 375,266 | - | - | - | |
Proceeds from maturities of marketable securities | ||||||
360,500 | 411,000 | 193,500 | - | - | - | |
Net cash provided by investing activities | ||||||
12,252 | -53,087 | -183,810 | -3,473 | -1,431 | -1,217 | |
Proceeds from equipment loan, net of issuance costs | ||||||
- | - | - | - | 1,500 | 462 | |
Proceeds from offering of common stock, net of issuance costs | ||||||
116,341 | 76,789 | 154,143 | 97,488 | - | - | |
Proceeds from exercise of stock options | ||||||
14,863 | 10,328 | 1,755 | 233 | - | - | |
Payments on construction financing lease obligation | ||||||
- | 857 | 764 | 560 | - | - | |
Issuances of common stock under benefit plans | ||||||
620 | 680 | - | - | - | - | |
Proceeds from the issuance of redeemable convertible preferred stock and tranche rights, net of issuance costs | ||||||
- | - | - | - | 141,711 | 17,980 | |
Payments of notes payable | ||||||
- | - | 600 | - | - | - | |
Payments of equipment loan principal | ||||||
- | - | - | - | 2,000 | - | |
Payments of final fee for loan payoff | ||||||
- | - | - | - | 80 | - | |
Proceeds from the issuance of common stock and restricted stock | ||||||
- | - | - | - | 6 | 41 | |
Payments of initial public offering costs | ||||||
- | - | - | - | 1,746 | - | |
Net cash provided by financing activities | ||||||
131,824 | 86,940 | 154,534 | 97,161 | 139,391 | 18,483 | |
Net (decrease) increase in cash, cash equivalents, and restricted cash | ||||||
103,407 | -11,854 | -38,693 | 43,442 | 132,517 | 8,611 | |
Supplemental disclosure of cash and non-cash activities: | ||||||
Accretion of redeemable convertible preferred stock to redemption value | ||||||
- | - | - | 47 | 394 | 309 | |
Fixed asset additions included in accounts payable and accrued expenses | ||||||
728 | 659 | 623 | 130 | 58 | - | |
Cash paid in connection with operating lease liabilities | ||||||
5,970 | - | - | - | - | - | |
Right-of-use assets obtained in exchange of operating lease obligations | ||||||
19,461 | - | - | - | - | - | |
Interest paid | ||||||
- | - | - | - | 91 | - | |
Accrual of final payment fee on equipment loan and debt discount | ||||||
- | - | - | - | - | 20 | |
Offering expenses included in accounts payable and accrued expenses | ||||||
15 | 92 | 235 | - | 502 | - | |
Conversion of anti-dilutive protection liability to common stock | ||||||
- | - | - | - | 1,936 | - | |
Reclassification of warrants to additional paid in capital | ||||||
- | - | - | 376 | - | - | |
Conversion of preferred stock to common stock upon closing of the initial public offering | ||||||
- | - | - | 199,962 | - | - | |
Reclassification of liability for common stock subject to repurchase | ||||||
- | 4 | 11 | 11 | 17 | 2 | |
Issuance of common stock for repayment of notes payable | ||||||
- | 22,030 | 14,823 | - | - | - | |
Reclassification of tranche rights upon issuance of redeemable convertible preferred stock | ||||||
- | - | - | - | 37,038 | 372 | |
Issuance of common stock for asset acquisition | ||||||
- | 1,942 | - | - | - | - | |