| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Collaboration and other research and development revenues | ||||||||||||||||||||
24,185 | 20,531 | 14,366 | 25,037 | 30,079 | 31,937 | 29,485 | 21,248 | 16,973 | 13,728 | 10,959 | 5,639 | 5,930 | 6,053 | 5,825 | 5,030 | 0 | - | 0 | 0 | - |
Operating expenses: | ||||||||||||||||||||
Research and development | ||||||||||||||||||||
115,626 | 96,898 | 81,302 | 76,043 | 85,196 | 90,654 | 97,885 | 100,838 | 85,438 | 83,159 | 83,570 | 74,006 | 67,118 | 56,979 | 35,970 | 28,988 | 25,840 | 18,846 | 0 | 0 | 0 |
General and administrative | ||||||||||||||||||||
64,835 | 64,555 | 60,816 | 58,416 | 58,313 | 55,010 | 55,516 | 54,817 | 52,400 | 50,502 | 49,864 | 48,524 | 48,788 | 46,262 | 40,554 | 33,461 | 24,584 | 18,095 | 0 | 0 | 0 |
Total operating expenses | ||||||||||||||||||||
180,461 | 161,453 | 142,118 | 134,459 | 143,509 | 145,664 | 153,401 | 155,655 | 137,838 | 133,661 | 133,434 | 122,530 | 115,906 | 103,241 | 76,524 | 62,449 | 50,424 | 36,941 | 0 | 0 | 0 |
Operating loss | ||||||||||||||||||||
-156,276 | -140,922 | -127,752 | -109,422 | -113,430 | -113,727 | -123,916 | -134,407 | -120,865 | -119,933 | -122,475 | -116,891 | -109,976 | -97,188 | -70,577 | -56,794 | -47,990 | -35,312 | 0 | 0 | 0 |
Other income, net: | ||||||||||||||||||||
Other income (expense), net | ||||||||||||||||||||
7,240 | -137 | -149 | -120 | 102 | 328 | 461 | 661 | 629 | 587 | 423 | 230 | 113 | -57 | -248 | -230 | -37,376 | -37,445 | 0 | 0 | 0 |
Interest income, net | ||||||||||||||||||||
6,815 | 7,313 | 6,871 | 6,215 | 5,064 | 3,445 | 2,366 | 1,296 | 70 | -978 | -1,459 | -1,271 | -672 | 62 | 385 | 199 | 12 | -143 | 0 | 0 | 0 |
Total other income, net | ||||||||||||||||||||
14,055 | 7,176 | 6,722 | 6,095 | 5,166 | 3,773 | 2,827 | 1,957 | 699 | -391 | -1,036 | -1,041 | -559 | 5 | 137 | -31 | -37,364 | -37,588 | 0 | 0 | 0 |
Net loss | ||||||||||||||||||||
-142,221 | -133,746 | -121,030 | -103,327 | -108,264 | -109,954 | -121,089 | -132,450 | -120,166 | -120,324 | -123,511 | -117,932 | -110,535 | -97,183 | -70,440 | -56,825 | -85,354 | -72,900 | 0 | 0 | 0 |
Accretion of redeemable convertible preferred stock to redemption value | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 47 | 146 | 250 | 346 | 394 | 0 | 0 | 0 |
Net loss attributable to common stockholders | ||||||||||||||||||||
- | - | - | - | - | 0 | - | - | - | - | - | - | - | -97,230 | -70,586 | -57,075 | -85,700 | -73,294 | 0 | 0 | 0 |
Net loss per share attributable to common stockholders, basic and diluted | ||||||||||||||||||||
-0.69 | -0.73 | -0.66 | -0.69 | -0.60 | -0.52 | -0.32 | -0.82 | -0.67 | -0.84 | -0.64 | -0.65 | -0.85 | -1.09 | -0.59 | -0.54 | -0.80 | -1.78 | -2.57 | -21.45 | -2.75 |
Weighted-average common shares outstanding, basic and diluted | ||||||||||||||||||||
54,590 | 52,204 | 49,820 | 49,070 | 48,838 | 48,032 | 47,414 | 46,952 | 45,992 | 42,671 | 41,307 | 40,830 | 36,485 | 35,805 | 35,505 | 35,286 | 22,280 | 3,162 | 2,925 | 2,222 | 1,957 |