| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Operating activities | ||||||
Net loss | ||||||
- | - | - | - | -13,322 | -33,853 | -19,995 |
Net loss | ||||||
-70,252 | -52,391 | -42,448 | -47,087 | - | - | - |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation | ||||||
68 | 54 | 41 | 23 | 11 | 153 | 67 |
Amortization of debt securities discounts | ||||||
467 | 426 | 53 | 41 | - | -393 | -255 |
Non-cash interest expense | ||||||
723 | 592 | 366 | 685 | - | 388 | 59 |
Gain on intellectual property sale | ||||||
- | - | 200 | - | - | - | - |
Amortization of operating lease right-of-use assets | ||||||
418 | - | - | - | - | - | - |
Common stock issued under Product Development Agreement | ||||||
226 | 428 | - | - | - | - | - |
Stock-based compensation | ||||||
5,679 | 5,007 | 4,243 | 3,190 | 227 | 3,319 | 1,388 |
Issuance of common stock in connection with license, asset purchase, and product development agreements | ||||||
- | - | - | 3,172 | - | - | - |
Non-cash interest expense | ||||||
- | - | - | - | 349 | - | - |
Issuance of common stock in connection with a license and asset purchase agreement | ||||||
- | - | - | - | 210 | - | - |
Change in fair value of obligation to issue shares to Eiccose | ||||||
- | - | - | 204 | - | - | - |
Change in fair value of warrants liability | ||||||
- | - | - | 165 | - | 183 | 162 |
Fair value of obligation to issue common stock in connection with Eiccose asset purchase agreement | ||||||
- | - | - | - | 1,457 | - | - |
Loss on disposal of property and equipment | ||||||
- | - | - | - | - | -1 | - |
Other items, net | ||||||
- | - | - | - | - | -74 | -17 |
Change in operating assets and liabilities: | ||||||
Prepaid expenses and other current assets | ||||||
3,698 | 780 | 131 | -326 | 684 | - | - |
Other assets | ||||||
2,075 | 124 | 169 | 89 | - | - | - |
Other assets | ||||||
- | - | - | - | 46 | - | - |
Accounts payable | ||||||
584 | 2,647 | 544 | 699 | 1,880 | - | - |
Accrued liabilities | ||||||
5,610 | 2,110 | -565 | 783 | 780 | - | - |
Operating lease liabilities | ||||||
-430 | - | - | - | - | - | - |
Other long term liabilities | ||||||
- | 212 | - | - | - | - | - |
Net cash used in operating activities | ||||||
-63,614 | -42,671 | -38,372 | -37,970 | - | - | - |
Investing activities | ||||||
Prepaid expenses and other assets | ||||||
- | - | - | - | - | 2,860 | -104 |
Accounts payable and accrued expenses | ||||||
- | - | - | - | - | 2,935 | 1,843 |
Other long-term liabilities | ||||||
- | - | - | - | 2 | 8 | - |
Net cash used in operating activities | ||||||
- | - | - | - | -9,133 | -29,259 | -16,196 |
Purchase of debt securities available-for-sale | ||||||
96,267 | 57,193 | 24,524 | 34,154 | - | - | - |
Purchases of investment securities | ||||||
- | - | - | - | - | 90,659 | 17,860 |
Proceeds from maturities of debt securities available-for-sale | ||||||
80,271 | 28,250 | 47,025 | 2,000 | - | 30,210 | 28,801 |
Proceeds from intellectual property sale | ||||||
- | - | 200 | - | - | - | - |
Cash received from merger transaction | ||||||
- | - | - | 28,018 | - | - | - |
Purchase of property and equipment | ||||||
475 | 142 | 44 | 58 | 44 | 739 | 87 |
Net cash provided by investing activities | ||||||
-16,471 | -29,085 | 22,657 | -4,194 | - | - | - |
Financing activities | ||||||
Net cash provided (used in) by investing activities | ||||||
- | - | - | - | -44 | -61,188 | 10,854 |
Proceeds from borrowings in connection with term loan, net of issuance costs | ||||||
6,627 | 9,935 | - | 14,759 | - | - | - |
Repayment of accrued exit fee and second amendment fee | ||||||
913 | - | - | - | - | - | - |
Proceeds from issuance of convertible promissory note, net of issuance costs | ||||||
- | - | - | - | 5,978 | - | 1,097 |
Proceeds from issuance of convertible preferred stock, net of issuance costs | ||||||
- | - | - | - | 7,200 | - | - |
Costs paid in connection with common stock offerings | ||||||
- | - | - | - | - | 7,661 | 1,693 |
Proceeds from borrowing under term loan | ||||||
- | - | - | - | - | 10,000 | - |
Costs paid in connection with term loan | ||||||
- | - | - | - | - | 387 | - |
Repayment of term loan | ||||||
- | - | - | - | - | 387 | - |
Other | ||||||
- | - | - | - | - | -1 | - |
Repayment of term loan | ||||||
1,667 | - | - | - | - | - | - |
Proceeds from issuance of common stock upon stock option exercises | ||||||
844 | 310 | 52 | 39 | - | - | - |
Proceeds from issuance of common stock upon private placement, net of issuance costs | ||||||
- | - | - | 32,108 | - | - | - |
Proceeds from issuance of common stock upon ESPP purchase | ||||||
130 | 96 | 142 | - | - | - | - |
Issuance of common stock upon offering at-the-market, net of issuance costs | ||||||
53,194 | 90,642 | 19,800 | 18,229 | - | 95,028 | - |
Payment of deferred offering costs | ||||||
19 | - | - | - | - | - | - |
Proceeds from issuance of common stock upon warrants exercises | ||||||
- | - | - | 7 | - | - | - |
Net cash provided by financing activities | ||||||
58,196 | 100,983 | 19,994 | 65,142 | - | - | - |
Net (decrease) increase in cash and cash equivalents | ||||||
-21,889 | 29,227 | 4,279 | 22,978 | - | - | - |
Net cash provided by financing activities | ||||||
- | - | - | - | 13,179 | 96,979 | -596 |
Net increase (decrease) in cash and cash equivalents | ||||||
- | - | - | - | 4,001 | 6,532 | -5,938 |
Supplemental disclosure of cash flow information: | ||||||
Interest paid | ||||||
- | - | - | - | - | 282 | - |
Conversion of warrant liability to common stock upon private placement | ||||||
- | - | - | 1,050 | - | - | - |
Issuance of common stock | ||||||
- | - | - | 3,172 | - | - | - |
Proceeds from issuance of common stock upon private placement, net of issuance cost | ||||||
- | - | - | 32,108 | - | - | - |
Non-cash net liabilities assumed in reverse merger | ||||||
- | - | - | 671 | - | - | - |
Conversion of convertible promissory note to common stock upon private placement | ||||||
- | - | - | 6,129 | - | 1,117 | - |
Share exchange related to non-controlling interest and special voting stock | ||||||
- | - | - | - | - | - | 7,824 |
Deemed dividend | ||||||
- | - | - | - | - | - | 856 |
Accrued purchases of property and equipment | ||||||
- | - | - | - | - | 23 | 166 |
Conversion of preferred stock to common stock upon reverse merger | ||||||
- | - | - | 22,567 | - | - | - |
Interest paid | ||||||
2,638 | 1,652 | 1,038 | - | - | - | - |
Issuance of warrants in connection with convertible promissory note | ||||||
- | - | - | - | 884 | - | - |
Warrant liability reclassification to equity | ||||||
- | - | - | - | - | 1,299 | - |
Capital expenditures funded by capital lease borrowings | ||||||
- | - | - | - | - | 12 | - |
Eiccose LLC [Member] | ||||||
Issuance of common stock | ||||||
- | - | - | 1,661 | - | - | - |