| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|
Revenue: | ||||||||
Total revenue | ||||||||
23,800 | 21,700 | 10,000 | 8,007 | 2,560 | 41,411 | 68,482 | 45,222 | 6,944 |
Operating expenses: | ||||||||
Research and development | ||||||||
132,639 | 105,833 | 109,661 | 91,461 | 111,209 | 75,595 | 57,567 | 38,482 | 22,911 |
General and administrative | ||||||||
68,303 | 43,972 | 37,181 | 28,372 | 23,900 | 20,866 | 14,042 | 7,508 | 5,000 |
Total operating expenses | ||||||||
200,942 | 149,805 | 146,842 | 119,833 | 135,109 | 96,461 | 71,609 | 45,990 | 27,911 |
Operating loss | ||||||||
-177,142 | -128,105 | -136,842 | -111,826 | -132,549 | -55,050 | -3,127 | -768 | -20,967 |
Other income, net: | ||||||||
Interest income, net | ||||||||
7,110 | 4,557 | 2,165 | 1,531 | 94 | 95 | 74 | 145 | 33 |
Other (expense), net | ||||||||
-13 | -25 | 32 | 83 | 79 | 59 | -81 | -78 | -23 |
Non-cash interest expense related to sale of future royalties | ||||||||
192 | - | - | - | - | - | - | - | - |
Other income, net | ||||||||
6,905 | 4,532 | 2,197 | 1,614 | 173 | 154 | -7 | 67 | 10 |
Loss before income taxes | ||||||||
-170,237 | -123,573 | -134,645 | -110,212 | -132,376 | -54,896 | -3,134 | -701 | -20,957 |
Income tax (provision) benefit | ||||||||
58 | 57 | -336 | - | 0 | 109 | 349 | 1 | - |
Net loss | ||||||||
-170,295 | -123,630 | -134,309 | -110,212 | -132,376 | -55,005 | -3,483 | -702 | -20,957 |
Other comprehensive income (loss): | ||||||||
Unrealized (loss) gain on available-for-sale securities | ||||||||
73 | -5 | 57 | -106 | - | - | - | - | - |
Comprehensive loss | ||||||||
-170,222 | -123,635 | -134,252 | -110,318 | -132,376 | -55,005 | -3,483 | -702 | -20,957 |
Reconciliation of net loss to net loss attributable to common stockholders: | ||||||||
Net loss | ||||||||
-170,295 | -123,630 | -134,309 | - | - | - | - | - | - |
Accretion of convertible preferred stock | ||||||||
2,940 | - | - | - | - | - | - | - | - |
Less: accretion of redeemable convertible preferred stock to redemption value | ||||||||
- | - | - | - | - | - | 264 | 486 | 45 |
Net loss attributable to common stockholders | ||||||||
-173,235 | -123,630 | -134,309 | - | - | - | -3,747 | -1,188 | -21,002 |
Net loss per share attributable to common stockholders: | ||||||||
Basic | ||||||||
-1.93 | -1.72 | -2.18 | -1.93 | -3.32 | -1.67 | -0.22 | -0.72 | -14.65 |
Diluted | ||||||||
-1.93 | -1.72 | -2.18 | -1.93 | -3.32 | -1.67 | -0.22 | -0.72 | -14.65 |
Weighted-average common shares outstanding used in net loss per share attributable to common stockholders: | ||||||||
Basic | ||||||||
89,891 | 71,864 | 61,471 | 57,126 | 39,839 | 33,027 | 17,049 | 1,645 | 1,434 |
Diluted | ||||||||
89,891 | 71,864 | 61,471 | 57,126 | 39,839 | 33,027 | 17,049 | 1,645 | 1,434 |