| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||||||||||||||||||
Net income (loss) | ||||||||||||||||||||||||
-78,249 | -61,946 | -68,377 | -54,221 | 87,379 | -60,039 | -49,911 | -45,730 | -46,130 | -37,891 | -45,219 | -43,337 | -40,541 | -28,956 | -17,402 | -14,035 | -14,585 | -13,122 | -12,801 | -12,395 | -11,466 | -9,457 | -9,806 | -9,238 | -7,874 |
Adjustments to reconcile net income (loss) to net cash used in operating activities: | ||||||||||||||||||||||||
Depreciation expense | ||||||||||||||||||||||||
106 | 82 | 92 | 55 | 71 | 109 | 67 | 63 | 61 | 104 | 62 | 65 | 69 | 62 | 63 | 63 | 64 | 67 | 54 | 56 | 59 | 56 | 51 | 41 | 12 |
Amortization of debt discount | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | 5 | 6 | 6 | 7 | 7 | 7 | 8 | - | - | - | - |
Amortization of debt issuance costs | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | 5 | 6 | 7 | 8 | 8 | 8 | 8 | - | - | - | - |
Accretion of premiums and discounts on investments | ||||||||||||||||||||||||
73 | 60 | 19 | 46 | 75 | - | - | - | - | -20 | -63 | -103 | -148 | -248 | -274 | -238 | -254 | -251 | -218 | -151 | -27 | -42 | -54 | -53 | -53 |
Non-cash interest expense related to the revenue interest liability | ||||||||||||||||||||||||
4,171 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Stock-based compensation expense | ||||||||||||||||||||||||
7,053 | 6,358 | 6,327 | 6,563 | 6,636 | 6,829 | 5,495 | 5,723 | 5,921 | 4,534 | 4,941 | 4,980 | 4,150 | 3,571 | 3,709 | 4,121 | 4,556 | 4,385 | 3,371 | 2,898 | 2,072 | 1,053 | 950 | 935 | 741 |
Loss related to assets held for sale | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | -23 | -6 |
Loss on sale of assets | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -1 | 0 | 10 | -11 |
Changes in assets and liabilities: | ||||||||||||||||||||||||
Prepaids and other assets | ||||||||||||||||||||||||
2,538 | 1,594 | 3,642 | -546 | -1,294 | -2,383 | 282 | 4,564 | 421 | 273 | -88 | -2,589 | 4,135 | -1,372 | 1,456 | -674 | 451 | -1,116 | 2,318 | -787 | 860 | -752 | 24 | -36 | 1,028 |
Deferred revenue | ||||||||||||||||||||||||
-982 | -466 | -981 | -982 | 4,581 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Inventories | ||||||||||||||||||||||||
1,841 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Accounts payable | ||||||||||||||||||||||||
-13,650 | 5,103 | -4,453 | -5,156 | -11,549 | 26,254 | -3,915 | 10,520 | -8,413 | 852 | 787 | 7,081 | 7,038 | 2,812 | 217 | 26 | 833 | -1,253 | -1,345 | 452 | 813 | -1,350 | -738 | 1,948 | -159 |
Other accrued liabilities | ||||||||||||||||||||||||
16,656 | -1,614 | 9,028 | -768 | 3,354 | -4,110 | 11,096 | -5,153 | 5,761 | -2,178 | 3,394 | 2,291 | -1,045 | 4,610 | 281 | 1,594 | -487 | 42 | 979 | -578 | 76 | 680 | 866 | 134 | -866 |
Net cash (used in) provided by operating activities | ||||||||||||||||||||||||
-69,347 | -49,994 | -58,029 | -54,009 | 91,691 | -28,692 | -37,527 | -39,198 | -43,221 | -34,874 | -35,884 | -26,228 | -34,316 | -16,316 | -14,304 | -7,307 | -9,803 | -8,449 | -11,830 | -8,614 | -9,263 | -8,208 | -8,631 | -6,078 | -9,104 |
Purchases of investments | ||||||||||||||||||||||||
4,420 | - | - | - | - | 0 | 4,941 | 5,920 | 14,620 | 6,604 | 176,204 | 8,578 | 28,191 | 33,704 | 50,904 | 42,370 | 70,252 | 38,364 | 74,061 | 97,780 | 70,354 | 43,288 | 0 | 1,800 | 3,000 |
Proceeds from sales/maturities of investments | ||||||||||||||||||||||||
31,200 | 5,000 | 21,675 | 26,950 | 45,885 | 38,673 | 45,015 | 37,490 | 44,903 | 55,003 | 48,681 | 35,686 | 44,373 | 41,545 | 63,974 | 61,633 | 40,290 | 43,922 | 36,875 | 27,182 | 12,813 | 4,425 | 1,000 | 2,500 | 4,426 |
Purchase of property and equipment | ||||||||||||||||||||||||
191 | 172 | 358 | 234 | 189 | - | - | - | - | 0 | 0 | 5 | 14 | - | - | - | - | 228 | 76 | 14 | 7 | 20 | 215 | 365 | 273 |
Net cash provided by investing activities | ||||||||||||||||||||||||
26,589 | -2,868 | -5,313 | 26,716 | 45,696 | 38,568 | 40,028 | 31,570 | 30,283 | 48,399 | -127,523 | 27,103 | 16,168 | 7,752 | 13,070 | 19,258 | -29,962 | 5,345 | -37,259 | -70,606 | -57,548 | -38,883 | 785 | 347 | 1,153 |
Financing activities | ||||||||||||||||||||||||
Proceeds from issuance of common stock, net of issuance costs | ||||||||||||||||||||||||
25,000 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1 | 0 | -168 | 190,150 | - | - | - | - |
Proceeds from exercise of common stock options | ||||||||||||||||||||||||
1,014 | 7,014 | 1,201 | 1,887 | 1,669 | 342 | 27 | 1,636 | 9,738 | 435 | 410 | 55 | 267 | 0 | 10 | 8 | 27 | 0 | 379 | 534 | 264 | 166 | 165 | 90 | 52 |
Payments on long-term debt | ||||||||||||||||||||||||
- | - | - | - | - | 0 | 153 | 451 | 445 | 437 | 431 | 424 | 417 | 411 | 404 | 398 | 391 | - | - | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||||||||||||||||||
26,014 | 7,014 | 976 | 126,536 | 1,669 | 342 | -126 | 1,185 | 9,293 | -81 | 164,058 | -369 | -150 | -411 | -394 | -390 | -364 | -384 | 126 | 366 | 190,414 | 91,897 | 134 | 5,037 | 52 |
Net increase (decrease) in cash and cash equivalents | ||||||||||||||||||||||||
-16,744 | -45,848 | -62,366 | 99,243 | 139,056 | 10,218 | 2,375 | -6,443 | -3,645 | 13,444 | 651 | 506 | -18,298 | -8,975 | -1,628 | 11,561 | -40,129 | -3,488 | -48,963 | -78,854 | 123,603 | 44,806 | -7,712 | -694 | -7,899 |
Supplemental disclosure of cash flow information: | ||||||||||||||||||||||||
Purchase of property and equipment not yet paid | ||||||||||||||||||||||||
408 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Non cash right of use asset | ||||||||||||||||||||||||
91 | 0 | 5 | 1 | 25 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Offering costs not yet paid | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 173 | - | - | - | - |