| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||||||||||||||||||
Net income (loss) | ||||||||||||||||||||||||
-262,793 | -97,165 | -95,258 | -76,792 | -68,301 | -201,810 | -179,662 | -174,970 | -172,577 | -166,988 | -158,053 | -130,236 | -100,934 | -74,978 | -59,144 | -54,543 | -52,903 | -49,784 | -46,119 | -43,124 | -39,967 | -36,375 | 0 | 0 | 0 |
Adjustments to reconcile net income (loss) to net cash used in operating activities: | ||||||||||||||||||||||||
Depreciation expense | ||||||||||||||||||||||||
335 | 300 | 327 | 302 | 310 | 300 | 295 | 290 | 292 | 300 | 258 | 259 | 257 | 252 | 257 | 248 | 241 | 236 | 225 | 222 | 207 | 160 | 0 | 0 | 0 |
Amortization of debt discount | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | 24 | 26 | 27 | 29 | 0 | 0 | 0 | - | - | - | - |
Amortization of debt issuance costs | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | 26 | 29 | 31 | 32 | 0 | 0 | 0 | - | - | - | - |
Accretion of premiums and discounts on investments | ||||||||||||||||||||||||
198 | 200 | 0 | 0 | 0 | - | - | - | - | -334 | -562 | -773 | -908 | -1,014 | -1,017 | -961 | -874 | -647 | -438 | -274 | -176 | -202 | 0 | 0 | 0 |
Non-cash interest expense related to the revenue interest liability | ||||||||||||||||||||||||
0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Stock-based compensation expense | ||||||||||||||||||||||||
26,301 | 25,884 | 26,355 | 25,523 | 24,683 | 23,968 | 21,673 | 21,119 | 20,376 | 18,605 | 17,642 | 16,410 | 15,551 | 15,957 | 16,771 | 16,433 | 15,210 | 12,726 | 9,394 | 6,973 | 5,010 | 3,679 | 0 | 0 | 0 |
Loss related to assets held for sale | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -29 | 0 | 0 | 0 |
Loss on sale of assets | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -2 | 0 | 0 | 0 |
Changes in assets and liabilities: | ||||||||||||||||||||||||
Prepaids and other assets | ||||||||||||||||||||||||
7,228 | 3,396 | -581 | -3,941 | 1,169 | 2,884 | 5,540 | 5,170 | -1,983 | 1,731 | 86 | 1,630 | 3,545 | -139 | 117 | 979 | 866 | 1,275 | 1,639 | -655 | 96 | 264 | 0 | 0 | 0 |
Deferred revenue | ||||||||||||||||||||||||
-3,411 | 2,152 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Inventories | ||||||||||||||||||||||||
0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Accounts payable | ||||||||||||||||||||||||
-18,156 | -16,055 | 5,096 | 5,634 | 21,310 | 24,446 | -956 | 3,746 | 307 | 15,758 | 17,718 | 17,148 | 10,093 | 3,888 | -177 | -1,739 | -1,313 | -1,333 | -1,430 | -823 | 673 | -299 | 0 | 0 | 0 |
Other accrued liabilities | ||||||||||||||||||||||||
23,302 | 10,000 | 7,504 | 9,572 | 5,187 | 7,594 | 9,526 | 1,824 | 9,268 | 2,462 | 9,250 | 6,137 | 5,440 | 5,998 | 1,430 | 2,128 | -44 | 519 | 1,157 | 1,044 | 1,756 | 814 | 0 | 0 | 0 |
Net cash (used in) provided by operating activities | ||||||||||||||||||||||||
-231,379 | -70,341 | -49,039 | -28,537 | -13,726 | -148,638 | -154,820 | -153,177 | -140,207 | -131,302 | -112,744 | -91,164 | -72,243 | -47,730 | -39,863 | -37,389 | -38,696 | -38,156 | -37,915 | -34,716 | -32,180 | -32,021 | 0 | 0 | 0 |
Purchases of investments | ||||||||||||||||||||||||
0 | - | - | - | - | 25,481 | 32,085 | 203,348 | 206,006 | 219,577 | 246,677 | 121,377 | 155,169 | 197,230 | 201,890 | 225,047 | 280,457 | 280,559 | 285,483 | 211,422 | 115,442 | 48,088 | 0 | 0 | 0 |
Proceeds from sales/maturities of investments | ||||||||||||||||||||||||
84,825 | 99,510 | 133,183 | 156,523 | 167,063 | 166,081 | 182,411 | 186,077 | 184,273 | 183,743 | 170,285 | 185,578 | 211,525 | 207,442 | 209,819 | 182,720 | 148,269 | 120,792 | 81,295 | 45,420 | 20,738 | 12,351 | 0 | 0 | 0 |
Purchase of property and equipment | ||||||||||||||||||||||||
955 | 953 | 0 | 0 | 0 | - | - | - | - | 19 | 0 | 0 | 0 | - | - | - | - | 325 | 117 | 256 | 607 | 873 | 0 | 0 | 0 |
Net cash provided by investing activities | ||||||||||||||||||||||||
45,124 | 64,231 | 105,667 | 151,008 | 155,862 | 140,449 | 150,280 | -17,271 | -21,738 | -35,853 | -76,500 | 64,093 | 56,248 | 10,118 | 7,711 | -42,618 | -132,482 | -160,068 | -204,296 | -166,252 | -95,299 | -36,598 | 0 | 0 | 0 |
Financing activities | ||||||||||||||||||||||||
Proceeds from issuance of common stock, net of issuance costs | ||||||||||||||||||||||||
0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 189,983 | 0 | 0 | 0 | - | - | - | - |
Proceeds from exercise of common stock options | ||||||||||||||||||||||||
11,116 | 11,771 | 5,099 | 3,925 | 3,674 | 11,743 | 11,836 | 12,219 | 10,638 | 1,167 | 732 | 332 | 285 | 45 | 45 | 414 | 940 | 1,177 | 1,343 | 1,129 | 685 | 473 | 0 | 0 | 0 |
Payments on long-term debt | ||||||||||||||||||||||||
- | - | - | - | - | 1,049 | 1,486 | 1,764 | 1,737 | 1,709 | 1,683 | 1,656 | 1,630 | 1,604 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||||||||||||||||||
160,540 | 136,195 | 129,523 | 128,421 | 3,070 | 10,694 | 10,271 | 174,455 | 172,901 | 163,458 | 163,128 | -1,324 | -1,345 | -1,559 | -1,532 | -1,012 | -256 | 190,522 | 282,803 | 282,811 | 287,482 | 97,120 | 0 | 0 | 0 |
Net increase (decrease) in cash and cash equivalents | ||||||||||||||||||||||||
-25,715 | 130,085 | 186,151 | 250,892 | 145,206 | 2,505 | 5,731 | 4,007 | 10,956 | -3,697 | -26,116 | -28,395 | -17,340 | -39,171 | -33,684 | -81,019 | -171,434 | -7,702 | 40,592 | 81,843 | 160,003 | 28,501 | 0 | 0 | 0 |
Supplemental disclosure of cash flow information: | ||||||||||||||||||||||||
Purchase of property and equipment not yet paid | ||||||||||||||||||||||||
0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Non cash right of use asset | ||||||||||||||||||||||||
97 | 31 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Offering costs not yet paid | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - | - | - | - |