| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||
Net loss | ||||||||
-98,149 | -66,598 | -42,952 | -33,462 | -29,992 | -25,883 | -20,894 | -14,239 | -13,427 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||
Depreciation and amortization | ||||||||
2,193 | 1,204 | 971 | 881 | 687 | 496 | 571 | 590 | 672 |
Stock-based compensation | ||||||||
17,410 | 6,293 | 3,606 | 3,184 | 2,400 | 2,434 | 1,554 | 155 | 172 |
Issuances of common stock for technology | ||||||||
- | - | - | - | - | - | 13 | 21 | - |
Amortization of debt discounts and debt issuance costs | ||||||||
115 | 76 | 81 | 139 | 176 | 24 | 394 | 84 | 23 |
Accretion and amortization of premiums and discounts on investments, net | ||||||||
478 | 335 | 25 | -171 | - | - | - | - | - |
Amortization of collaboration contract asset | ||||||||
620 | 42 | - | - | - | - | - | - | - |
Noncash interest expense | ||||||||
- | 373 | 321 | 492 | 651 | 167 | 147 | 121 | 13 |
Deferred rent | ||||||||
- | -192 | -1,085 | 7 | 24 | 52 | 195 | 197 | -228 |
Deferred revenue | ||||||||
-8,526 | 12,259 | -2,105 | -2,401 | -7,335 | - | 63 | 83 | 646 |
Issuance on common stock for license agreement | ||||||||
- | 6,100 | - | - | - | - | - | - | - |
Non-cash loss on extinguishment of debt | ||||||||
- | - | 30 | - | - | - | - | - | - |
Cash payments included in loss on extinguishment of debt | ||||||||
- | - | 88 | - | - | - | - | - | - |
Stockbased milestone charges and change in fair value of exchangeable shares | ||||||||
- | - | - | - | - | 375 | 2,767 | - | - |
Change in fair value of preferred stock warrants | ||||||||
- | - | - | - | - | - | 8 | -37 | -5 |
Loss on disposal of assets | ||||||||
- | - | - | - | - | - | -18 | - | -117 |
Stock-based milestone charges | ||||||||
- | - | - | - | - | - | - | -12 | 356 |
Loss on extinguishment of debt | ||||||||
- | - | - | - | - | 3 | - | -323 | -9 |
Changes in operating assets and liabilities: | ||||||||
Accounts receivable | ||||||||
-500 | 500 | - | - | - | - | - | - | - |
Prepaid expenses and other assets | ||||||||
1,911 | 2,010 | 428 | 381 | 107 | 146 | 1,271 | 405 | -209 |
Accounts payable and accrued expenses | ||||||||
4,277 | 4,254 | 2,511 | 1,561 | 477 | 163 | 1,578 | 405 | 134 |
Right-of-use assets and lease liabilities, net | ||||||||
774 | - | - | - | - | - | - | - | - |
Net cash used in operating activities | ||||||||
-83,175 | -38,650 | -36,817 | -29,823 | -18,397 | -22,419 | -15,373 | -13,274 | -12,145 |
Investing activities | ||||||||
Proceeds from sale of property and equipment | ||||||||
- | - | - | 18 | - | - | 6 | - | 202 |
Purchases of property and equipment | ||||||||
7,395 | 2,303 | 1,725 | 457 | 1,498 | 882 | 244 | 709 | 2 |
Purchases of investments | ||||||||
248,858 | 55,660 | 39,971 | 19,675 | - | - | - | - | - |
Maturities of investments | ||||||||
98,800 | 57,500 | 31,500 | 16,000 | - | - | - | - | - |
Net cash provided by investing activities | ||||||||
-157,453 | -463 | -10,196 | -4,114 | -1,498 | -882 | -238 | -709 | 200 |
Financing activities | ||||||||
Issuance of common stock from equity incentive plans, net of issuance costs | ||||||||
2,522 | 2,693 | 205 | 186 | 420 | 142 | 23 | - | - |
Repurchase of common stock for cash | ||||||||
- | - | - | - | - | - | - | - | 7 |
Issuance of convertible promissory notes | ||||||||
- | - | - | - | - | - | 23,736 | - | 1,000 |
Proceeds from public offering of common stock, net of issuance costs | ||||||||
162,406 | 134,577 | 43,206 | - | 4,580 | - | - | 207 | 14 |
Proceeds from public offerings of common stock, net of issuance costs | ||||||||
- | - | - | - | 32,149 | - | 40,480 | - | - |
Proceeds from CIRM award | ||||||||
- | 3,510 | - | - | - | - | - | - | - |
Proceeds from long–term debt | ||||||||
- | - | 15,000 | - | - | 20,000 | - | - | 3,400 |
Payment on convertible promissory note | ||||||||
- | - | - | - | - | - | 1,679 | - | - |
Payments of debt issuance costs | ||||||||
- | - | 10 | - | - | 26 | - | - | - |
Payments included in loss on extinguishment of debt | ||||||||
- | - | 88 | - | - | - | - | - | - |
Principal repayments of long–term debt | ||||||||
15,000 | - | 10,764 | 7,689 | 1,546 | 1,750 | 2,000 | 250 | 800 |
Issuance of preferred stock for cash, net of offering costs | ||||||||
- | - | - | - | - | - | - | 16,726 | 3,500 |
Net cash provided by financing activities | ||||||||
149,928 | 140,780 | 47,356 | 57,737 | 35,603 | 18,366 | 60,560 | 16,683 | 7,107 |
Net change in cash, cash equivalents and restricted cash | ||||||||
-90,700 | 101,667 | 343 | 23,800 | 15,708 | -4,935 | 44,949 | 2,700 | -4,838 |
Supplemental disclosure of cash flow information | ||||||||
Interest paid | ||||||||
2,291 | 1,242 | 2,314 | 1,067 | 1,353 | 494 | 250 | 282 | 90 |
Supplemental schedule of noncash investing and financing activities | ||||||||
Issuance of warrants for common stock in connection with long–term debt | ||||||||
- | - | 217 | - | - | 375 | - | - | 172 |
Purchases of property and equipment in accounts payable | ||||||||
602 | 37 | 48 | - | - | - | - | - | - |
Beneficial conversion feature related to convertible notes | ||||||||
- | - | - | - | - | - | 336 | - | - |
Conversion of convertible preferred stock into common stock | ||||||||
- | - | - | - | - | - | 56,526 | 11,889 | - |
Conversion of convertible notes into common stock | ||||||||
- | - | - | - | - | - | 22,076 | - | - |
Exchange of exchangeable shares into common stock | ||||||||
- | - | - | - | - | - | 3,318 | - | - |
Warrant liability reclassification to equity | ||||||||
- | - | - | - | - | - | 192 | - | - |
Common Stock | ||||||||
Proceeds from private placement issuances of stock, net of issuance costs | ||||||||
- | - | -65 | 28,849 | - | - | - | - | - |
Preferred Stock | ||||||||
Proceeds from private placement issuances of stock, net of issuance costs | ||||||||
- | - | -128 | 36,391 | - | - | - | - | - |