| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||||||||||||||||||
Net loss | ||||||||||||||||||||||||
-111,909 | -98,149 | -85,874 | -76,047 | -72,223 | -66,598 | -63,068 | -56,970 | -46,961 | -42,952 | -38,395 | -36,448 | -35,211 | -33,462 | -32,968 | -31,117 | -30,488 | -29,992 | -28,779 | -28,496 | -26,784 | -25,883 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||||||||||
Depreciation and amortization | ||||||||||||||||||||||||
2,458 | 2,193 | 1,897 | 1,620 | 1,358 | 1,204 | 1,167 | 1,101 | 1,051 | 971 | 884 | 858 | 860 | 881 | 888 | 857 | 786 | 687 | 602 | 530 | 501 | 496 | 0 | 0 | 0 |
Stock-based compensation | ||||||||||||||||||||||||
20,455 | 17,410 | 14,611 | 11,680 | 8,779 | 6,293 | 5,404 | 4,633 | 4,121 | 3,606 | 3,530 | 3,441 | 3,254 | 3,184 | 2,845 | 2,637 | 2,589 | 2,400 | 2,532 | 2,485 | 2,171 | 2,434 | 0 | 0 | 0 |
Amortization of debt discounts and debt issuance costs | ||||||||||||||||||||||||
- | 115 | 66 | 70 | 72 | 76 | 76 | 76 | 76 | 81 | 90 | 104 | 123 | 139 | 155 | 167 | 172 | 176 | 139 | 97 | 60 | 24 | 0 | 0 | 0 |
Accretion and amortization of premiums and discounts on investments, net | ||||||||||||||||||||||||
202 | 478 | 594 | 426 | 265 | 335 | 303 | 223 | 99 | 25 | 8 | -40 | -115 | -171 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Amortization of collaboration contract asset | ||||||||||||||||||||||||
681 | 620 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Noncash interest expense | ||||||||||||||||||||||||
- | - | 332 | 347 | 360 | 373 | 373 | 368 | 336 | 321 | 323 | 346 | 412 | 492 | 553 | 606 | 644 | 651 | 585 | 479 | 321 | 167 | 0 | 0 | 0 |
Deferred rent | ||||||||||||||||||||||||
- | - | - | - | - | -192 | -406 | -608 | -882 | -1,085 | -817 | -551 | -272 | 7 | 16 | 24 | 21 | 24 | 33 | 44 | 53 | 52 | 0 | 0 | 0 |
Deferred revenue | ||||||||||||||||||||||||
-6,909 | -8,526 | -3,387 | 8,517 | 10,653 | 12,259 | 7,895 | -2,105 | -3,157 | -2,105 | -5,855 | -4,803 | -2,697 | -2,401 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Stock-based milestone charges | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 |
Changes in operating assets and liabilities: | ||||||||||||||||||||||||
Accounts receivable | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Prepaid expenses and other assets | ||||||||||||||||||||||||
2,067 | 1,911 | 585 | 1,155 | 1,382 | 2,010 | 1,373 | 1,128 | 339 | 428 | 75 | -285 | 194 | 381 | 314 | 784 | 522 | 107 | 378 | 127 | 147 | 146 | 0 | 0 | 0 |
Accounts payable and accrued expenses | ||||||||||||||||||||||||
2,219 | 4,277 | 3,102 | 618 | 2,323 | 4,254 | 5,472 | 4,113 | 1,507 | 2,511 | 1,174 | 1,534 | 2,448 | 1,561 | 1,062 | 789 | 998 | 477 | 686 | 1,011 | 389 | 163 | 0 | 0 | 0 |
Right-of-use assets and lease liabilities, net | ||||||||||||||||||||||||
2,398 | 774 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash used in operating activities | ||||||||||||||||||||||||
-92,355 | -83,175 | -68,660 | -52,378 | -43,592 | -38,650 | -38,351 | -44,564 | -41,913 | -36,817 | -33,647 | -31,394 | -30,026 | -29,823 | -29,242 | -28,857 | -19,274 | -18,397 | -17,581 | -15,971 | -23,539 | -22,419 | 0 | 0 | 0 |
Investing activities | ||||||||||||||||||||||||
Purchases of property and equipment | ||||||||||||||||||||||||
6,719 | 7,395 | 5,922 | 5,382 | 3,865 | 2,303 | 1,983 | 1,621 | 1,754 | 1,725 | 968 | 639 | 434 | 457 | 595 | 1,217 | 1,224 | 1,498 | 1,591 | 1,123 | 936 | 882 | 0 | 0 | 0 |
Purchases of investments | ||||||||||||||||||||||||
- | - | - | - | - | 55,660 | 55,660 | 55,660 | 55,660 | 39,971 | 39,971 | 43,480 | 43,480 | 19,675 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Maturities of investments | ||||||||||||||||||||||||
113,144 | 98,800 | 81,550 | 58,000 | 56,000 | 57,500 | 54,000 | 54,000 | 41,750 | 31,500 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash provided by investing activities | ||||||||||||||||||||||||
-142,433 | -157,453 | -30,554 | -53,564 | 52,135 | -463 | -3,643 | -3,281 | -15,664 | -10,196 | -17,421 | -30,601 | -26,146 | -4,114 | -10,270 | -11,383 | -17,390 | -1,498 | -1,591 | -1,123 | -936 | -882 | 0 | 0 | 0 |
Financing activities | ||||||||||||||||||||||||
Issuance of common stock from equity incentive plans, net of issuance costs | ||||||||||||||||||||||||
2,275 | 2,522 | 2,888 | 3,858 | 3,345 | 2,693 | 1,947 | 920 | 777 | 205 | 191 | 109 | 73 | 186 | 202 | 399 | 492 | 420 | 0 | 0 | 0 | - | - | - | - |
Proceeds from public offering of common stock, net of issuance costs | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 |
Issuance costs from public offering of common stock | ||||||||||||||||||||||||
- | - | - | - | - | - | - | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Proceeds from CIRM award | ||||||||||||||||||||||||
0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Principal repayments of long–term debt | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 10,764 | 12,739 | 7,968 | 7,827 | 7,689 | 0 | 0 | 0 | - | - | - | - | 1,750 | 0 | 0 | 0 |
Net cash provided by financing activities | ||||||||||||||||||||||||
150,121 | 149,928 | 165,555 | 141,215 | 141,683 | 140,780 | 182,115 | 53,049 | 49,881 | 47,356 | 57,200 | 57,188 | 57,293 | 57,737 | 3,754 | -5,066 | 33,802 | 35,603 | 46,499 | 56,258 | 18,943 | 18,366 | 0 | 0 | 0 |
Net change in cash, cash equivalents and restricted cash | ||||||||||||||||||||||||
-84,667 | -90,700 | 66,341 | 35,273 | 150,226 | 101,667 | 140,121 | 5,204 | -7,696 | 343 | 6,132 | -4,807 | 1,121 | 23,800 | -35,758 | -45,306 | -2,862 | 15,708 | 27,327 | 39,164 | -5,532 | -4,935 | 0 | 0 | 0 |
Supplemental disclosure of cash flow information | ||||||||||||||||||||||||
Interest paid | ||||||||||||||||||||||||
- | 2,291 | 1,251 | 1,255 | 1,252 | 1,242 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Supplemental schedule of noncash investing and financing activities | ||||||||||||||||||||||||
Purchases of property and equipment in accounts payable | ||||||||||||||||||||||||
-537 | 602 | 791 | 617 | 1,262 | 37 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Right-of use assets obtained in exchange for lease obligations | ||||||||||||||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |