| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|
Collaboration revenue | ||||||||
10,680 | 4,740 | 4,106 | 4,402 | 2,431 | - | 626 | 1,268 | 833 |
Grant revenue | ||||||||
- | - | - | - | - | - | 345 | 1,402 | 337 |
Total revenue | ||||||||
- | - | - | - | - | - | 971 | 2,670 | 1,170 |
Operating expenses: | ||||||||
Research and development | ||||||||
87,770 | 56,024 | 34,358 | 26,452 | 19,861 | 16,435 | 12,007 | 11,999 | 9,858 |
General and administrative | ||||||||
23,637 | 15,808 | 11,873 | 9,913 | 10,352 | 8,469 | 6,639 | 4,228 | 4,605 |
Total operating expenses | ||||||||
111,407 | 71,832 | 46,231 | 36,365 | 30,213 | 24,904 | 18,646 | 16,227 | 14,463 |
Loss from operations | ||||||||
-100,727 | -67,092 | -42,125 | -31,963 | -27,782 | -24,904 | -17,675 | -13,557 | -13,293 |
Other income (expense): | ||||||||
Interest income | ||||||||
4,330 | 2,190 | 559 | 138 | 10 | 2 | 6 | 1 | 2 |
Interest expense | ||||||||
1,752 | 1,696 | 1,268 | 1,637 | 2,220 | 549 | 796 | 487 | 127 |
Loss on extinguishment of debt | ||||||||
- | - | -118 | - | - | -432 | - | -323 | -9 |
Change in fair value of exchangeable shares | ||||||||
- | - | - | - | - | - | -2,421 | -90 | 5 |
Change in fair value of warrant liability | ||||||||
- | - | - | - | - | - | 8 | -37 | -5 |
Total other income, net | ||||||||
2,578 | 494 | -827 | -1,499 | -2,210 | -979 | -3,219 | -682 | -134 |
Net loss | ||||||||
-98,149 | -66,598 | -42,952 | -33,462 | -29,992 | -25,883 | -20,894 | -14,239 | -13,427 |
Other comprehensive income (loss): | ||||||||
Unrealized gain on available-for-sale securities, net | ||||||||
24 | 1 | -2 | -1 | - | - | - | - | - |
Comprehensive loss | ||||||||
-98,125 | -66,597 | -42,954 | -33,463 | -29,992 | -25,883 | - | - | - |
Net loss per common share, basic and diluted | ||||||||
-1.44 | -1.19 | -1.02 | -1.05 | -1.18 | -1.27 | -3.54 | -13.06 | -16.16 |
Weighted-average common shares used to compute basic and diluted net loss per share | ||||||||
68,190 | 56,195 | 41,982 | 31,754 | 25,484 | 20,451 | 5,896 | 1,090 | 830 |