| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 | Dec'13 | Sep'13 | Jun'13 | Mar'13 | Sep'12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Collaboration revenue | |||||||||||||||||||||||||||||
10,563 | 10,680 | 9,539 | 8,136 | 6,346 | 4,740 | 4,106 | 4,106 | 4,105 | 4,106 | 4,106 | 4,106 | 4,107 | 4,402 | 4,401 | 3,704 | 0 | - | 0 | 0 | - | - | - | - | - | 626 | 834 | 0 | 0 | 0 |
Grant revenue | |||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 345 | 665 | 0 | 0 | 0 |
Total revenue | |||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 971 | 1,499 | 0 | 0 | 0 |
Operating expenses: | |||||||||||||||||||||||||||||
Research and development | |||||||||||||||||||||||||||||
99,320 | 87,770 | 76,656 | 67,091 | 62,276 | 56,024 | 51,816 | 46,757 | 37,868 | 34,358 | 30,701 | 28,927 | 27,782 | 26,452 | 25,655 | 23,854 | 21,929 | 19,861 | 18,293 | 17,370 | 16,481 | 16,435 | 15,601 | 14,899 | 13,998 | 12,007 | 12,291 | 0 | 0 | 0 |
General and administrative | |||||||||||||||||||||||||||||
26,016 | 23,637 | 21,273 | 19,008 | 17,554 | 15,808 | 14,885 | 13,592 | 12,445 | 11,873 | 10,940 | 10,763 | 10,343 | 9,913 | 10,017 | 9,757 | 10,198 | 10,352 | 9,875 | 9,428 | 8,810 | 8,469 | 8,262 | 8,337 | 7,757 | 6,639 | 5,631 | 0 | 0 | 0 |
Total operating expenses | |||||||||||||||||||||||||||||
125,336 | 111,407 | 97,929 | 86,099 | 79,830 | 71,832 | 66,701 | 60,349 | 50,313 | 46,231 | 41,641 | 39,690 | 38,125 | 36,365 | 35,672 | 33,611 | 32,127 | 30,213 | 28,168 | 26,798 | 25,291 | 24,904 | 23,863 | 23,236 | 21,755 | 18,646 | 17,922 | 0 | 0 | 0 |
Loss from operations | |||||||||||||||||||||||||||||
-114,773 | -100,727 | -88,390 | -77,963 | -73,484 | -67,092 | -62,595 | -56,243 | -46,208 | -42,125 | -37,535 | -35,584 | -34,018 | -31,963 | -31,221 | -29,160 | -28,374 | -27,782 | -26,813 | -26,469 | -25,291 | -24,904 | -23,863 | -23,027 | -21,256 | -17,675 | -16,423 | 0 | 0 | 0 |
Other income (expense): | |||||||||||||||||||||||||||||
Interest income | |||||||||||||||||||||||||||||
4,211 | 4,330 | 4,160 | 3,589 | 2,950 | 2,190 | 1,205 | 1,018 | 779 | 559 | 443 | 328 | 222 | 138 | 98 | 65 | 36 | 10 | 8 | 0 | 0 | - | - | 0 | - | 6 | 0 | 0 | 0 | - |
Interest expense | |||||||||||||||||||||||||||||
- | 1,752 | 1,644 | 1,673 | 1,689 | 1,696 | 1,678 | 1,627 | 1,414 | 1,268 | 1,185 | 1,192 | 1,415 | 1,637 | 1,845 | 2,022 | 2,150 | 2,220 | 1,974 | 1,599 | 1,064 | 549 | 636 | 679 | 739 | 796 | 0 | 0 | 0 | - |
Loss on extinguishment of debt | |||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | 0 | - | - | - | - | - | - | - |
Change in fair value of exchangeable shares | |||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -2,421 | 0 | 0 | 0 | - |
Change in fair value of warrant liability | |||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 8 | 0 | 0 | 0 | - |
Total other income, net | |||||||||||||||||||||||||||||
2,864 | 2,578 | 2,516 | 1,916 | 1,261 | 494 | -473 | -727 | -753 | -827 | -860 | -864 | -1,193 | -1,499 | -1,747 | -1,957 | -2,114 | -2,210 | -1,966 | -2,027 | -1,493 | -979 | -1,526 | -1,832 | -3,070 | -3,219 | -2,845 | 0 | 0 | 0 |
Net loss | |||||||||||||||||||||||||||||
-111,909 | -98,149 | -85,874 | -76,047 | -72,223 | -66,598 | -63,068 | -56,970 | -46,961 | -42,952 | -38,395 | -36,448 | -35,211 | -33,462 | -32,968 | -31,117 | -30,488 | -29,992 | -28,779 | -28,496 | -26,784 | -25,883 | -25,389 | -24,859 | -24,326 | -20,894 | -19,268 | 0 | 0 | 0 |
Other comprehensive income (loss): | |||||||||||||||||||||||||||||
Unrealized gain on available-for-sale securities, net | |||||||||||||||||||||||||||||
142 | 24 | 65 | 108 | 13 | 1 | -1 | 24 | 21 | -2 | -16 | -50 | -48 | -1 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - |
Comprehensive loss | |||||||||||||||||||||||||||||
-111,767 | -98,125 | -85,809 | -75,939 | -72,210 | -66,597 | -63,069 | -56,946 | -46,940 | -42,954 | -38,411 | -36,498 | -35,259 | -33,463 | -32,965 | -31,106 | -30,474 | -29,992 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - |
Net loss per common share, basic and diluted | |||||||||||||||||||||||||||||
-0.44 | -0.38 | -0.40 | -0.36 | -0.30 | -0.24 | -0.31 | -0.37 | -0.27 | -0.29 | -0.26 | -0.23 | -0.24 | -0.20 | -0.27 | -0.29 | -0.29 | -0.23 | -0.24 | -0.33 | -0.38 | -0.31 | -0.32 | -0.30 | -0.34 | 8.65 | -4.81 | -4.46 | -2.92 | -3.51 |
Weighted-average common shares used to compute basic and diluted net loss per share | |||||||||||||||||||||||||||||
75,886 | 75,699 | 66,929 | 65,213 | 64,920 | 64,703 | 54,185 | 53,130 | 52,763 | 43,705 | 41,428 | 41,406 | 41,388 | 37,280 | 32,090 | 28,868 | 28,777 | 28,811 | 28,650 | 23,920 | 20,554 | 20,503 | 20,489 | 20,467 | 20,346 | 19,869 | 1,262 | 1,239 | 1,213 | 1,171 |