| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Revenue: | ||||||
Collaboration services and other revenue (includes $1,578, $1,357 and $2,895 from a related party) | ||||||
- | - | - | - | 32,735 | 20,410 | 7,209 |
Total revenue | ||||||
256,577 | 212,958 | 130,996 | 183,189 | 180,828 | 137,601 | 102,170 |
Operating costs and expenses: | ||||||
Cost of goods sold | ||||||
1,147 | 0 | 0 | - | - | - | - |
Research and development | ||||||
209,265 | 235,839 | 196,517 | 187,206 | 214,089 | 150,794 | 85,710 |
Selling, general and administrative | ||||||
135,479 | 63,812 | 51,760 | 46,025 | 44,364 | 36,909 | 24,409 |
Total operating costs and expenses | ||||||
345,891 | 299,651 | 248,277 | 233,231 | 258,453 | 187,703 | 110,119 |
Loss from operations | ||||||
-89,314 | -86,693 | -117,281 | -50,042 | -77,625 | -50,102 | -7,949 |
Interest and other, net | ||||||
Interest expense | ||||||
2,876 | 10,991 | 9,706 | 10,725 | 11,033 | 11,108 | 10,702 |
Interest income and other, net | ||||||
15,548 | 11,568 | 6,433 | 2,628 | 3,121 | 1,706 | 3,708 |
Total interest and other, net | ||||||
12,672 | 577 | -3,273 | -8,097 | -7,912 | -9,402 | -6,994 |
Loss before income taxes | ||||||
-76,642 | -86,116 | -120,554 | -58,139 | -85,537 | -59,504 | -14,943 |
Benefit from income taxes | ||||||
328 | 304 | 321 | -71 | 242 | 0 | 0 |
Net loss | ||||||
-76,970 | -86,420 | -120,875 | -58,068 | -85,779 | -59,504 | -14,943 |
Net loss per share - basic and diluted | ||||||
-0.89 | -1.03 | -1.66 | -0.93 | -1.42 | -3.17 | -1.13 |
Weighted average number of common shares used to calculate net loss per share - basic and diluted | ||||||
86,633 | 84,062 | 72,987 | 62,744 | 60,337 | 18,775 | 13,186 |
License Revenue [Member] | ||||||
Total revenue | ||||||
177,086 | 22,269 | 9,933 | 50,607 | 148,093 | 117,191 | 94,961 |
Development and Other Revenue [Member] | ||||||
Total revenue | ||||||
114,115 | 125,913 | 121,063 | 132,582 | - | - | - |
Product Revenue, Net [Member] | ||||||
Total revenue | ||||||
-34,624 | 64,776 | 0 | 0 | - | - | - |