| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Cash flows from operating activities | ||||||
Net loss | ||||||
-149,773 | -169,659 | -137,481 | -71,894 | - | - | - |
Net loss | ||||||
- | - | - | - | -46,315 | -27,313 | -18,186 |
Adjustments to reconcile net loss to cash used in operating activities | ||||||
Depreciation | ||||||
1,100 | 1,700 | 2,000 | 1,151 | 238 | 120 | 79 |
Amortization of right-of-use assets | ||||||
1,337 | 0 | 0 | - | - | - | - |
Stock-based compensation expense | ||||||
15,901 | 15,459 | 11,542 | 6,770 | 4,583 | 2,450 | 996 |
Non cash interest expense | ||||||
564 | 0 | 0 | - | - | - | - |
Loss on disposal of property and equipment | ||||||
- | - | - | - | - | - | -14 |
Other non-cash charges | ||||||
- | - | - | 37 | 40 | 16 | 63 |
Accretion of discount on marketable securities | ||||||
1,337 | 1,320 | -333 | -729 | - | - | - |
Loss from debt extinguishment | ||||||
-352 | - | - | - | - | - | - |
Amortization of (discount) premium on marketable securities | ||||||
- | - | - | - | 871 | 366 | 151 |
Loss on disposal of fixed assets | ||||||
- | - | - | -2,283 | -150 | - | - |
Amortization of debt discount and debt issuance costs | ||||||
8,714 | 7,805 | 4,826 | - | - | - | - |
Premium paid on securities purchased | ||||||
34 | 214 | 857 | 543 | - | - | - |
Changes in operating assets and liabilities: | ||||||
Accounts receivable | ||||||
23,994 | 12,711 | 410 | -95 | - | - | - |
Inventory | ||||||
7,674 | 5,244 | 1,799 | - | - | - | - |
Prepaid expenses and other current assets | ||||||
-126 | 2,097 | -387 | 2,873 | 526 | 320 | -343 |
Accounts payable | ||||||
1,702 | 5,141 | 4,188 | -993 | 1,581 | 518 | 475 |
Accrued expenses and other current liabilities | ||||||
5,326 | 707 | 9,432 | 2,766 | 429 | 1,017 | -124 |
Lease liabilities | ||||||
-1,027 | 0 | 0 | - | - | - | - |
Net cash used in operating activities | ||||||
-148,758 | -160,419 | -107,831 | -62,472 | - | - | - |
Net cash used in operating activities | ||||||
- | - | - | - | -38,949 | -23,144 | -16,186 |
Cash flows from investing activities | ||||||
Purchases of property and equipment | ||||||
3,894 | 852 | 2,146 | 8,440 | 5,197 | 802 | 405 |
Change in restricted cash | ||||||
- | - | - | - | -48 | - | 98 |
Purchases of marketable securities | ||||||
115,466 | 222,482 | 356,754 | 196,061 | 145,798 | 79,383 | 15,015 |
Sale and redemption of marketable securities | ||||||
234,124 | 348,918 | 240,228 | 72,147 | 137,702 | 30,735 | 31,160 |
Net cash provided by investing activities | ||||||
114,764 | 125,584 | -118,672 | -132,354 | - | - | - |
Cash flows from financing activities | ||||||
Net cash provided by investing activities | ||||||
- | - | - | - | -13,245 | -49,451 | 15,641 |
Proceeds from the issuance of 2024 convertible notes | ||||||
- | - | 201,250 | - | - | - | - |
Proceeds from borrowings under term loan | ||||||
40,000 | - | - | - | - | - | - |
Payment of debt issuance costs | ||||||
161 | - | 6,470 | 42 | 108 | - | 40 |
Proceeds from the offering of common stock | ||||||
- | - | 132,666 | 147,889 | - | 162,137 | - |
Payments on notes payable | ||||||
14,367 | 10,000 | 8,333 | - | 3,500 | - | - |
Payments on debt | ||||||
- | - | - | - | - | 1,500 | - |
Proceeds from borrowings under term loan | ||||||
- | - | - | - | - | - | 5,000 |
Proceeds from issuance of notes payable | ||||||
- | - | - | 15,000 | 15,004 | - | - |
Payments of public offering costs | ||||||
- | - | 490 | 293 | 225 | 1,517 | 1,072 |
Proceeds from the exercise of stock options | ||||||
1,726 | 1,653 | 3,858 | 167 | 593 | 304 | 12 |
Proceeds from employee stock purchase plan | ||||||
1,820 | 2,022 | 1,016 | 476 | 276 | 80 | - |
Net cash provided by (used in) financing activities | ||||||
29,018 | -6,325 | 323,497 | 163,197 | - | - | - |
Net increase in cash and cash equivalents | ||||||
-4,976 | -41,160 | 96,994 | -31,629 | - | - | - |
Cash paid for interest | ||||||
- | - | - | - | 572 | 364 | 367 |
Non-cash investing and financing activities | ||||||
Right-of-use asset obtained in exchange for operating lease obligation | ||||||
9,560 | - | - | - | - | - | - |
Deferred initial public offering costs included in accounts payable or accrued expenses | ||||||
- | - | - | - | - | - | 550 |
Public offering costs included in accounts payable or accrued expenses | ||||||
- | - | - | 95 | - | 224 | - |
Portion of debt proceeds allocated to equity component | ||||||
- | - | 62,466 | - | - | - | - |
Purchases of property and equipment in accounts payable and accrued expenses | ||||||
2,202 | 986 | 9 | 622 | - | - | - |
Net cash used in financing activities | ||||||
- | - | - | - | 12,040 | 159,505 | 3,898 |
Net increase in cash, cash equivalents, and restricted cash | ||||||
- | - | - | - | -40,154 | 86,909 | 3,352 |
Supplemental disclosures of cash flow information | ||||||
Cash paid for interest | ||||||
8,049 | 7,874 | 5,080 | 1,297 | - | - | - |
Conversion of convertible preferred stock into common stock | ||||||
- | - | - | - | - | 74,806 | - |
Purchases of property and equipment in accounts payable and accrued expenses | ||||||
- | - | - | - | 1,576 | 52 | - |