| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenue: | ||||||||||
Net product sales | ||||||||||
182,237 | 91,245 | 36,930 | 4,958 | - | - | - | - | - | - | - |
Cost of goods sold | ||||||||||
21,963 | 14,404 | 6,236 | 833 | - | - | - | - | - | - | - |
Research revenue | ||||||||||
- | - | - | - | - | 1,224 | 363 | 11,591 | 14,794 | - | 17,545 |
Collaboration and milestone revenue | ||||||||||
- | - | - | - | - | - | - | 6,820 | 6,640 | 922 | 46,813 |
Total revenue | ||||||||||
- | - | - | - | - | 1,224 | 363 | 18,411 | 21,434 | 922 | 64,358 |
Gross profit | ||||||||||
160,274 | 76,841 | 30,694 | 4,125 | - | 1,224 | - | - | - | - | - |
Operating expenses: | ||||||||||
Research and development | ||||||||||
286,378 | 270,902 | 149,310 | 104,793 | 76,943 | 47,624 | 41,944 | 50,273 | 50,856 | 39,042 | 48,081 |
Selling, general, and administrative | ||||||||||
169,861 | 127,200 | 88,671 | 71,151 | 47,269 | 20,717 | 18,893 | 19,364 | 19,880 | 15,660 | 19,973 |
Changes in fair value of contingent consideration payable | ||||||||||
-3,297 | -3,300 | 234,322 | -6,760 | -4,377 | -100 | - | - | - | - | - |
Loss on impairment of assets | ||||||||||
0 | 0 | 465,427 | 0 | - | - | - | - | - | - | - |
Depreciation and amortization | ||||||||||
4,775 | 4,216 | 3,593 | 3,242 | 1,833 | 1,547 | 1,719 | 1,705 | 1,585 | 2,058 | 2,132 |
Total operating expenses | ||||||||||
464,311 | 405,618 | 472,679 | 186,015 | 130,437 | 69,925 | 64,544 | 71,342 | 72,321 | 56,760 | 71,708 |
Loss from operations | ||||||||||
-304,037 | -328,777 | -441,985 | -181,890 | -130,437 | -68,701 | -64,181 | -52,931 | -50,887 | -55,838 | -7,350 |
Other income (expense): | ||||||||||
Interest income | ||||||||||
10,249 | 10,461 | 4,096 | 1,602 | 929 | 223 | 174 | 316 | 160 | 156 | 997 |
Interest expense | ||||||||||
18,872 | 22,402 | 17,240 | 5,398 | 1,578 | 1,484 | 46 | 89 | 148 | 260 | 278 |
Restructuring charges | ||||||||||
- | - | - | 69 | 15 | -63 | 1,988 | - | - | - | 1,522 |
Loss on exchange of convertible notes | ||||||||||
-40,600 | 0 | 0 | - | - | - | - | - | - | - | - |
Change in fair value of derivatives | ||||||||||
0 | -2,739 | 0 | 0 | - | - | -908 | -653 | -2,764 | 1,410 | - |
Loss on extinguishment of debt | ||||||||||
- | - | - | -13,302 | -952 | - | - | - | - | - | - |
Other (expense) income | ||||||||||
-2,626 | -5,632 | 6,008 | -4,793 | -80 | -77 | - | 21 | 70 | 1,277 | 64 |
Loss before income tax | ||||||||||
-355,910 | -349,089 | -449,121 | -203,781 | -132,118 | -70,039 | -63,145 | -52,030 | -48,041 | -56,075 | -6,567 |
Income tax expense | ||||||||||
478 | -94 | -165,119 | -3,739 | - | -1,113 | -3,512 | -3,245 | -3,629 | -1,139 | - |
Net loss attributable to common stockholders | ||||||||||
-356,388 | -348,995 | -284,002 | -200,042 | -132,118 | -68,926 | -59,633 | -48,785 | -44,412 | -54,936 | -6,567 |
Net loss attributable to common stockholders per common share - basic and diluted (in dollars per share) | ||||||||||
-1.48 | -1.88 | -1.85 | -1.49 | -1.20 | -0.93 | -1.16 | -1.07 | -1.28 | -1.98 | -0.29 |
Weighted-average common shares outstanding - basic and diluted (in shares) | ||||||||||
240,421 | 185,790 | 153,355 | 134,401 | 109,923 | 74,444 | 51,286 | 45,565 | 34,569 | 27,734 | 22,624 |