| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||
Net loss | ||||||||
- | - | - | - | 249,647 | -37,424 | -28,872 | -27,595 | - |
Net loss | ||||||||
-137,202 | -140,447 | -150,222 | -65,697 | - | - | - | - | 19,710 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||
Depreciation and amortization | ||||||||
5,300 | 5,000 | 2,500 | 1,742 | 1,678 | 1,552 | 1,694 | 1,643 | 1,631 |
Impairment of fixed assets | ||||||||
1,959 | - | - | - | - | - | - | - | - |
Loss on disposal of property and equipment | ||||||||
- | -38 | -95 | -9 | -3 | -41 | - | 5 | -2 |
Stock-based compensation expense | ||||||||
22,815 | 29,468 | 34,173 | 32,885 | 11,467 | 3,418 | 2,146 | - | - |
Amortization of discounts and premiums on marketable securities | ||||||||
2,163 | 1,750 | -1,621 | -4,187 | -2,025 | -1,491 | -432 | - | - |
Non-cash operating lease expense | ||||||||
2,351 | - | - | - | - | - | - | - | - |
Revaluation of preferred stock warrant liability | ||||||||
- | - | - | - | - | - | 500 | 119 | -60 |
Excess tax benefits from employee equity incentive plans | ||||||||
- | - | - | -3,123 | -3,122 | - | - | - | - |
Deferred income taxes | ||||||||
- | - | - | 15,071 | -15,071 | - | - | - | - |
Stock-based compensation expense | ||||||||
- | - | - | - | - | - | - | 1,721 | 2,927 |
Amortization of premium on marketable securities | ||||||||
- | - | - | - | - | - | - | 538 | 892 |
Changes in operating assets and liabilities: | ||||||||
Receivables from collaborative partners | ||||||||
-999 | -8,037 | 9,174 | -95 | 3,644 | 114 | -101 | -449 | 846 |
Income tax receivable | ||||||||
- | - | -4,670 | 4,670 | - | - | - | - | - |
Prepaid, other current assets and other long-term assets | ||||||||
-6,800 | 10,120 | -4,235 | 2,999 | 4,782 | 579 | 981 | -372 | 313 |
Restricted cash | ||||||||
- | - | - | 1,543 | - | - | - | - | - |
Accounts payable | ||||||||
-72 | -265 | 1,903 | -1,560 | 798 | 701 | -209 | 196 | -729 |
Accrued personnel-related expenses | ||||||||
-578 | 227 | -801 | 1,079 | 2,260 | 1,661 | 707 | -19 | 656 |
Deferred revenue | ||||||||
-5,484 | -9,670 | -9,070 | -16,771 | - | - | - | - | - |
Payable to collaborative partner | ||||||||
- | - | - | - | - | - | - | -3,000 | 3,000 |
Deferred revenue | ||||||||
- | - | - | - | -11,789 | 45,530 | 280 | 7,379 | -5,188 |
Deferred rent | ||||||||
- | 802 | 3,699 | -768 | -513 | -549 | 247 | 457 | 696 |
Income tax payable | ||||||||
- | - | - | -52,843 | 49,720 | - | - | - | - |
Other accrued liabilities, and other long-term liabilities | ||||||||
-5,699 | -3,854 | 4,174 | 8,909 | 4,177 | -463 | -375 | - | - |
Operating lease liabilities | ||||||||
-2,905 | - | - | - | - | - | - | - | - |
Other accrued liabilities and other long-term liabilities | ||||||||
- | - | - | - | - | - | - | -414 | 789 |
Net cash used in operating activities | ||||||||
- | - | - | - | 289,098 | 15,265 | -25,330 | -18,397 | - |
Net cash used in operating activities | ||||||||
-113,866 | -122,514 | -112,184 | -79,751 | - | - | - | - | 23,287 |
Investing activities | ||||||||
Purchases of marketable securities | ||||||||
193,063 | 377,365 | 330,363 | 516,752 | 458,058 | 158,674 | 79,776 | 45,419 | 71,773 |
Maturities of marketable securities | ||||||||
321,015 | 386,200 | 509,500 | 466,000 | 222,250 | 90,955 | 38,403 | - | - |
Proceeds from disposal of property and equipment | ||||||||
- | - | 12 | - | - | - | - | - | - |
Maturities of marketable securities | ||||||||
- | - | - | - | - | - | - | 64,636 | 45,738 |
Purchases of property and equipment | ||||||||
1,776 | 11,331 | 4,941 | 2,961 | 2,426 | 1,643 | 807 | 737 | 970 |
Change in restricted cash | ||||||||
- | - | - | - | - | - | - | -38 | - |
Net cash (used in) provided by investing activities | ||||||||
- | - | - | - | -238,234 | -69,362 | -42,180 | 18,518 | - |
Net cash provided by investing activities | ||||||||
126,176 | -2,496 | 174,208 | -53,713 | - | - | - | - | -27,005 |
Financing activities | ||||||||
Proceeds from public offering of common stock, net of issuance costs | ||||||||
- | 107,612 | - | - | 78,693 | 58,728 | 63,849 | - | - |
Deferred offering costs | ||||||||
- | - | - | - | - | 16 | - | - | - |
Proceeds from exercise of stock options | ||||||||
- | - | - | - | - | - | - | - | 39 |
Proceeds from issuances of convertible preferred stock, net of issuance costs) | ||||||||
- | - | - | - | - | - | - | 6,819 | - |
Proceeds from issuance of common stock under equity incentive plans | ||||||||
1,136 | 3,963 | 4,022 | 8,323 | 5,147 | 2,459 | 440 | 105 | - |
Repurchase of shares to satisfy tax withholding obligations | ||||||||
1,599 | 2,402 | 13,909 | 14,054 | - | - | - | - | - |
Excess tax benefits from employee equity incentive plans | ||||||||
- | - | - | 3,123 | - | - | - | - | - |
Net cash used in financing activities | ||||||||
-463 | 109,173 | -9,887 | -8,854 | - | - | - | - | 26 |
Net increase (decrease) in cash and cash equivalents and restricted cash | ||||||||
11,847 | -15,837 | 52,137 | -142,318 | - | - | - | - | - |
Supplemental disclosure | ||||||||
Payments under capital lease obligation | ||||||||
- | - | - | - | - | - | 9 | 15 | 13 |
Net cash provided by (used in) financing activities | ||||||||
- | - | - | - | 83,840 | 61,203 | 64,280 | 6,909 | - |
Income taxes paid | ||||||||
- | - | 1,704 | 11,433 | - | - | - | - | - |
Property and equipment purchases included in accrued liabilities | ||||||||
29 | 716 | 9,033 | 1,232 | - | - | - | - | - |
Tenant improvement by the landlord | ||||||||
- | - | 14,324 | - | - | - | - | - | - |
Supplemental cash flow information | ||||||||
Net increase (decrease) in cash and cash equivalents | ||||||||
- | - | - | - | 134,704 | 7,106 | -3,230 | 7,030 | -3,692 |
Accrued and deferred offering costs | ||||||||
- | - | - | - | - | 144 | - | - | - |