| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
CASH FLOWS FROM OPERATING ACTIVITIES: | ||||||
Net loss | ||||||
-266,766 | -174,193 | -117,024 | -82,468 | -46,360 | -20,807 | -18,116 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation and amortization | ||||||
8,605 | 4,607 | 1,658 | 1,160 | 873 | 666 | 534 |
Amortization (accretion) of premium (discount) on marketable securities | ||||||
2,057 | 661 | -704 | -75 | - | - | - |
Non-cash interest expense | ||||||
43 | - | - | - | - | - | - |
Amortization of operating lease right-of-use assets | ||||||
1,327 | - | - | - | - | - | - |
Remeasurement of Series A redeemable convertible preferred stock liability | ||||||
- | - | - | - | - | -297 | -2,500 |
Stock-based compensation | ||||||
45,651 | 30,080 | 13,682 | 9,235 | 3,223 | 350 | 138 |
Gain on lease modification | ||||||
8,301 | - | - | - | - | - | - |
Loss from disposal of fixed assets, net | ||||||
- | -45 | - | - | -33 | - | - |
Fair value of stock issued for license | ||||||
- | - | - | - | 4,492 | - | 0 |
Changes in operating assets and liabilities: | ||||||
Accounts receivables | ||||||
2,637 | - | - | - | - | - | - |
Inventories | ||||||
1,277 | - | - | - | - | - | - |
Prepaid expenses and other assets | ||||||
3,085 | 2,500 | 1,856 | 761 | 87 | 753 | 73 |
Other assets, current | ||||||
2,112 | 1,278 | 162 | 512 | -22 | 323 | -149 |
Accounts payable | ||||||
4,499 | -1,285 | 2,771 | 1,066 | 2,705 | -304 | -465 |
Payable due to related party | ||||||
- | - | - | - | -14 | -115 | -68 |
Accrued liabilities | ||||||
24,706 | 8,031 | 3,280 | 1,794 | 2,834 | 599 | 183 |
Accrued compensation | ||||||
7,543 | 1,457 | 3,612 | 2,725 | 1,395 | 271 | 494 |
Other liabilities, current | ||||||
-1,482 | 742 | -63 | 23 | 19 | 17 | 38 |
Operating lease liabilities | ||||||
893 | - | - | - | - | - | - |
Other liabilities | ||||||
33 | -420 | 376 | -60 | -25 | -19 | 31 |
Net cash used in operating activities | ||||||
-194,417 | -135,375 | -93,022 | -67,723 | -30,890 | -20,121 | -14,700 |
CASH FLOWS FROM INVESTING ACTIVITIES: | ||||||
Purchase of property and equipment | ||||||
3,460 | 4,824 | 3,101 | 1,352 | 993 | 323 | 940 |
Sale of property and equipment | ||||||
45 | 75 | - | - | - | - | - |
Purchase of marketable securities | ||||||
434,919 | 361,405 | 127,724 | 105,500 | - | - | - |
Maturities of marketable securities | ||||||
361,473 | 181,997 | 96,000 | - | - | - | - |
Increase in restricted cash | ||||||
- | - | - | - | - | 60 | 0 |
Purchases of other assets | ||||||
- | - | 175 | - | - | - | - |
Net cash provided by (used in) investing activities | ||||||
-76,861 | -184,157 | -35,000 | -106,852 | -993 | -383 | -940 |
CASH FLOWS FROM FINANCING ACTIVITIES: | ||||||
Proceeds from issuance of common stock in public offering, net | ||||||
219,443 | 396,501 | 231,955 | 116,995 | 126,230 | - | 0 |
Proceeds from issuance of long-term debt, net of debt issuance costs | ||||||
72,475 | - | - | - | - | - | - |
Proceeds from issuance of redeemable convertible preferred stock, net of issuance costs | ||||||
- | - | - | - | - | 68,838 | 15,235 |
Proceeds from sale of restricted stock | ||||||
- | - | - | - | 2,108 | 408 | 43 |
Proceeds from issuance of common stock in settlement of employee stock purchase plan and exercise of stock options | ||||||
13,857 | 7,669 | 3,892 | 1,240 | 45 | 49 | 1 |
Repurchases of unvested restricted stock purchases | ||||||
- | 12 | 421 | 90 | 67 | - | 0 |
Tax paid related to net share settlement of equity awards | ||||||
7,617 | 6,252 | 238 | - | - | - | - |
Net cash provided by financing activities | ||||||
298,158 | 397,906 | 235,188 | 118,145 | 128,316 | 69,295 | 15,279 |
Net increase (decrease) in cash, cash equivalents and restricted cash | ||||||
26,880 | 78,374 | 107,166 | -56,430 | 96,433 | 48,791 | -361 |
SUPPLEMENTAL DISCLOSURES OF NON-CASH INVESTING AND FINANCING INFORMATION: | ||||||
Leasehold improvements paid for by landlord | ||||||
17,231 | - | 11,086 | - | - | - | - |
Remeasurement and settlement of fair value of Series A redeemable convertible preferred stock liability | ||||||
- | - | - | - | - | 2,526 | 4,885 |
Accretion of Series A redeemable convertible preferred stock | ||||||
- | - | - | - | 4,180 | 2,965 | 1,735 |
Accrued purchase of property and equipment | ||||||
78 | 48 | 1,536 | 114 | - | - | - |
Accrued issuance costs | ||||||
85 | 467 | - | - | - | - | - |