| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CASH FLOWS FROM OPERATING ACTIVITIES: | ||||||||||||||||||||
Net loss | ||||||||||||||||||||
-73,026 | -95,975 | -64,547 | -57,321 | -48,923 | -49,202 | -43,067 | -40,368 | -41,556 | -41,252 | -28,557 | -23,883 | -23,332 | -27,207 | -20,986 | -17,675 | -16,600 | -15,585 | -14,764 | -8,594 | -7,417 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||||||
Depreciation and amortization | ||||||||||||||||||||
2,238 | 2,311 | 2,107 | 2,093 | 2,094 | 2,098 | 1,167 | 672 | 670 | 650 | 400 | 275 | 333 | 319 | 321 | 278 | 242 | 267 | 217 | 206 | 183 |
Amortization (accretion) of premium (discount) on marketable securities | ||||||||||||||||||||
101 | 333 | 520 | 639 | 565 | 435 | 333 | -14 | -93 | -143 | -181 | -196 | -184 | - | - | - | - | - | - | - | - |
Non-cash interest expense | ||||||||||||||||||||
412 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Amortization of operating lease right-of-use assets | ||||||||||||||||||||
693 | 995 | 120 | 112 | 100 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Stock-based compensation | ||||||||||||||||||||
16,367 | 12,797 | 12,453 | 10,948 | 9,453 | 7,528 | 6,968 | 7,800 | 7,784 | 4,741 | 3,707 | 2,660 | 2,574 | 3,351 | 3,152 | 1,465 | 1,267 | 1,492 | 874 | 535 | 322 |
Loss from disposal of fixed assets, net | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -4 | 0 | -11 | -18 |
Changes in operating assets and liabilities: | ||||||||||||||||||||
Accounts receivables | ||||||||||||||||||||
1,941 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Inventories | ||||||||||||||||||||
13,218 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Prepaid expenses and other assets | ||||||||||||||||||||
147 | -2,132 | 5,276 | -10 | -49 | -1,996 | 2,077 | 1,742 | 677 | -1,017 | 323 | 1,202 | 1,348 | 277 | 57 | -261 | 688 | -402 | 1,205 | -338 | -378 |
Other assets, current | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -232 | 153 | -305 | 362 |
Accounts payable | ||||||||||||||||||||
2,567 | 3,411 | 530 | -714 | 1,272 | 846 | 1,586 | -3,979 | 262 | 3,710 | -1,562 | 1,886 | -1,263 | 2,544 | -2,667 | 322 | 867 | 1,854 | 156 | 361 | 334 |
Payable due to related party | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 39 |
Accrued liabilities | ||||||||||||||||||||
-6,766 | 19,149 | -579 | 5,249 | 887 | 2,149 | 3,988 | 1,769 | 125 | 2,380 | -475 | -1,107 | 2,482 | 48 | 950 | -18 | 814 | 906 | 877 | 297 | 754 |
Accrued compensation | ||||||||||||||||||||
-6,309 | 7,128 | 2,210 | 2,612 | -4,407 | 2,857 | 939 | 1,517 | -3,856 | 3,058 | 1,029 | 1,717 | -2,192 | 1,616 | 495 | 1,141 | -527 | 794 | 666 | 240 | -305 |
Operating lease liabilities | ||||||||||||||||||||
1,762 | 1,751 | -295 | -287 | -276 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Other liabilities | ||||||||||||||||||||
-1,153 | - | - | - | 0 | -919 | -73 | 183 | 389 | 421 | -12 | -20 | -13 | -35 | -13 | -3 | -9 | -18 | 0 | -2 | -5 |
Net cash used in operating activities | ||||||||||||||||||||
-78,622 | -62,337 | -53,827 | -37,937 | -40,316 | -33,573 | -30,902 | -34,134 | -36,766 | -25,357 | -25,612 | -19,478 | -22,575 | -20,052 | -18,808 | -14,229 | -14,634 | -9,647 | -8,840 | -6,342 | -6,061 |
CASH FLOWS FROM INVESTING ACTIVITIES: | ||||||||||||||||||||
Purchase of property and equipment | ||||||||||||||||||||
2,524 | 2,262 | 650 | 492 | 56 | -122 | 1,646 | 2,798 | 502 | 1,328 | 1,198 | 401 | 174 | 246 | 151 | 577 | 378 | 218 | 220 | 386 | 169 |
Purchase of marketable securities | ||||||||||||||||||||
57,936 | 104,789 | 134,833 | 31,120 | 164,177 | - | - | - | - | 3 | 2,860 | 46,120 | 78,741 | - | - | - | - | - | - | - | - |
Maturities of marketable securities | ||||||||||||||||||||
151,586 | 127,636 | 112,914 | 57,341 | 63,582 | 73,290 | 31,929 | 34,702 | 42,076 | 43,891 | 19,324 | 23,498 | 9,287 | - | - | - | - | - | - | - | - |
Net cash provided by (used in) investing activities | ||||||||||||||||||||
91,126 | 20,630 | -22,569 | 25,729 | -100,651 | -28,287 | -116,790 | -80,654 | 41,574 | 42,385 | 15,266 | -23,023 | -69,628 | -105,746 | -151 | -577 | -378 | -218 | -220 | -386 | -169 |
CASH FLOWS FROM FINANCING ACTIVITIES: | ||||||||||||||||||||
Proceeds from issuance of common stock in public offering, net | ||||||||||||||||||||
- | 0 | 5,454 | 192,782 | 21,207 | 141,382 | 0 | 179 | 254,940 | 96,330 | 0 | -80 | 135,705 | - | - | - | - | - | - | - | - |
Payment of deferred offering costs | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 521 | 67 |
Proceeds from sale of restricted stock | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 2,063 | 45 |
Proceeds from issuance of common stock in settlement of employee stock purchase plan and exercise of stock options | ||||||||||||||||||||
2,968 | 7,967 | 1,624 | 2,341 | 1,925 | 947 | 2,826 | 1,075 | 2,821 | 826 | 1,412 | 578 | 1,076 | 123 | 619 | 4 | 494 | 1 | 33 | 11 | 0 |
Payments of debt issuance costs | ||||||||||||||||||||
85 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Repurchases of unvested restricted stock purchases | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1 | -1 | 50 | 17 |
Tax paid related to net share settlement of equity awards | ||||||||||||||||||||
2,099 | 4,102 | 1,532 | 1,297 | 686 | -1 | 849 | 0 | 5,404 | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||||||||||||||
784 | 76,340 | 5,546 | 193,826 | 22,446 | 142,326 | 1,969 | 1,254 | 252,357 | 97,155 | 754 | 498 | 136,781 | 33 | 4,886 | 112,732 | 494 | -130 | 126,982 | 1,503 | -39 |
Net increase (decrease) in cash, cash equivalents and restricted cash | ||||||||||||||||||||
13,288 | 34,633 | -70,850 | 181,618 | -118,521 | 80,466 | -145,723 | -113,534 | 257,165 | 114,183 | -9,592 | -42,003 | 44,578 | -125,765 | -14,073 | 97,926 | -14,518 | -9,995 | 117,922 | -5,225 | -6,269 |
SUPPLEMENTAL DISCLOSURES OF NON-CASH INVESTING AND FINANCING INFORMATION: | ||||||||||||||||||||
Leasehold improvements paid for by landlord | ||||||||||||||||||||
9,461 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Accretion of Series A redeemable convertible preferred stock | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 787 | 2,153 | 1,240 |
Accrued purchase of property and equipment | ||||||||||||||||||||
563 | 2 | -71 | 1 | 146 | 2,221 | -772 | -2,488 | 1,087 | 1,438 | 68 | -80 | 110 | -133 | 234 | -30 | 43 | - | - | -330 | 356 |
Accrued issuance costs | ||||||||||||||||||||
-85 | - | - | 487 | -41 | - | - | - | 127 | - | - | - | 88 | - | - | - | - | - | -244 | -246 | 620 |