| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenues: | ||||||||||
License fees and royalties | ||||||||||
460 | 1,066 | 1,065 | 6,162 | - | - | - | - | - | - | - |
Collaboration revenue | ||||||||||
- | - | - | - | 35,000 | - | - | - | 300 | 925 | 450 |
License fees and royalties | ||||||||||
- | - | - | - | 1,371 | 1,153 | 1,283 | 2,709 | 2,138 | 2,638 | 1,276 |
Total revenues | ||||||||||
- | - | - | - | 36,371 | 1,153 | 1,283 | - | 2,438 | 3,563 | 1,726 |
Operating expenses: | ||||||||||
Research and development | ||||||||||
52,072 | 13,432 | 11,033 | 18,047 | 17,831 | 20,707 | 23,155 | 51,368 | 69,316 | 61,687 | 57,617 |
Acquired in-process research and development | ||||||||||
- | - | - | - | - | - | - | - | - | 35,000 | 0 |
Restructuring charges | ||||||||||
- | - | - | - | 1,306 | - | 1,462 | 2,702 | 5,449 | - | 0 |
General and administrative | ||||||||||
20,893 | 18,707 | 19,287 | 18,761 | 17,793 | 16,758 | 15,624 | 20,397 | 23,789 | 18,043 | 14,343 |
Total operating expenses | ||||||||||
72,965 | 32,139 | 30,320 | 36,808 | 36,930 | 37,465 | 40,241 | 74,467 | 98,554 | 114,730 | 71,960 |
Loss from operations | ||||||||||
-72,505 | -31,073 | -29,255 | -30,646 | -559 | -36,312 | -38,958 | -71,758 | -96,116 | -111,167 | -70,234 |
Unrealized gain on derivatives | ||||||||||
- | - | - | - | 16 | 351 | -316 | 13 | 643 | 190 | - |
Unrealized gain on fair value of derivatives | ||||||||||
- | - | - | - | - | - | - | - | - | - | 157 |
Interest and other income | ||||||||||
4,221 | 3,291 | 1,416 | 1,192 | 677 | 373 | 951 | 3,097 | 1,024 | 2,045 | 1,374 |
Gain on settlement | ||||||||||
- | 1,460 | - | - | - | - | - | - | - | - | - |
Change in fair value of equity investment | ||||||||||
-195 | -541 | - | - | - | - | - | - | - | - | - |
Losses recognized under equity method investment | ||||||||||
- | - | - | - | - | - | - | - | -503 | -2,347 | -1,338 |
Losses recognized from debt extinguishment | ||||||||||
- | - | - | - | - | - | - | - | -1,664 | - | 0 |
Other expense | ||||||||||
69 | 154 | 77 | 83 | 88 | 82 | 56 | 233 | 237 | 98 | - |
Interest and other expense | ||||||||||
- | - | - | - | - | - | - | - | - | - | 143 |
Net loss | ||||||||||
-68,548 | -27,017 | -27,916 | -29,537 | 46 | -35,670 | -38,379 | -68,881 | -96,853 | -111,377 | -70,184 |
Basic | ||||||||||
- | - | - | - | 0.00 | -0.23 | -0.30 | - | - | - | - |
Diluted | ||||||||||
- | - | - | - | 0.00 | -0.23 | -0.30 | - | - | - | - |
Basic | ||||||||||
- | - | - | - | 158,036 | 153,540 | 128,380 | - | - | - | - |
Diluted | ||||||||||
- | - | - | - | 162,663 | 153,540 | 128,380 | - | - | - | - |
Deemed dividend on derivatives | ||||||||||
- | - | - | - | - | - | - | - | - | - | 190 |
Net loss applicable to common stockholders | ||||||||||
- | - | - | - | - | - | - | - | - | - | -70,374 |
Basic and diluted net loss per share | ||||||||||
-0.36 | -0.15 | -0.18 | -0.19 | - | - | - | -0.54 | -0.78 | -1.14 | -0.80 |
Shares used in computing basic and diluted net loss per share | ||||||||||
190,160 | 176,504 | 159,224 | 159,045 | - | - | - | 126,941 | 124,506 | 97,601 | - |
Shares used in computing net loss per share applicable to common stockholders (in shares) | ||||||||||
- | - | - | - | - | - | - | - | - | - | 88,078 |