| Dec'19 | Dec'18 | Dec'17 | Dec'16 | |||
|---|---|---|---|---|---|---|
OPERATING ACTIVITIES: | ||||||
Net loss | ||||||
-67,851 | -84,263 | -83,221 | -46,139 | |||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation and amortization | ||||||
11,411 | 7,136 | 5,206 | 3,693 | |||
Amortization of ROU | ||||||
2,198 | 0 | 0 | - | |||
Unrealized translation gains (loss) on obligation related to royalty | ||||||
147 | 357 | -980 | 0 | |||
Re-valuation of contingent consideration | ||||||
300 | 0 | 0 | - | |||
Non-cash stock-based compensation | ||||||
16,954 | 6,851 | 3,670 | 1,971 | |||
Non-cash interest expense | ||||||
0 | 13 | -685 | 1,024 | |||
Loss on debt extinguishment | ||||||
0 | 0 | -5,100 | 0 | |||
Amortization of premium (discount) on marketable securities | ||||||
2,310 | 412 | -359 | -287 | |||
Benefit from income tax differences | ||||||
-1,597 | 0 | 0 | - | |||
Changes in operating assets and liabilities: | ||||||
Accounts receivable, net | ||||||
7,389 | 22,903 | 9,292 | 2,786 | |||
Inventory | ||||||
6,045 | 1,849 | 4,518 | 351 | |||
Prepaid expenses and other current assets | ||||||
6,185 | 3,663 | -30 | 610 | |||
Other assets | ||||||
2,852 | 451 | 883 | -12 | |||
Accounts payable | ||||||
4,341 | 5,046 | 1,250 | 2,145 | |||
Accrued compensation | ||||||
5,571 | 8,075 | 2,348 | 1,374 | |||
Accrued expenses | ||||||
9,213 | 286 | 4,657 | 508 | |||
Long-term operating lease liabilities net of ROU | ||||||
1,039 | 0 | 0 | - | |||
Deferred rent | ||||||
0 | -1,307 | -204 | -467 | |||
Deferred revenue | ||||||
-3,861 | 13,025 | 1,215 | 1,695 | |||
Other liabilities | ||||||
76 | 0 | 0 | - | |||
Net cash used in operating activities | ||||||
-47,134 | -72,185 | -72,235 | -36,710 | |||
INVESTING ACTIVITIES: | ||||||
Purchases of marketable securities | ||||||
614,290 | 287,450 | 236,835 | 341,415 | |||
Maturity of marketable securities | ||||||
325,333 | 154,625 | 75,402 | 369,383 | |||
Business acquisition, net of cash acquired | ||||||
7,328 | 0 | 0 | - | |||
Purchases of property and equipment | ||||||
18,717 | 20,203 | 6,681 | 1,766 | |||
Purchase of intangible assets | ||||||
2,500 | 0 | 0 | 0 | |||
Payment in connection with a license agreement | ||||||
68 | 0 | 2,302 | - | |||
Net cash provided by investing activities | ||||||
-317,570 | -153,028 | -170,416 | 26,202 | |||
FINANCING ACTIVITIES: | ||||||
Payments made on royalty obligations | ||||||
311 | 0 | 25,844 | 379 | |||
Payments made on capital lease obligations | ||||||
128 | 443 | 244 | -4 | |||
Proceeds from issuance of convertible preferred stock, net of issuance costs | ||||||
0 | 0 | 319,536 | 40,049 | |||
Proceeds from issuance of common stock under employee stock purchase plan | ||||||
6,395 | 0 | 0 | - | |||
Proceeds from issuance of common stock upon exercise of stock options | ||||||
11,639 | 3,111 | 753 | 266 | |||
Proceeds from issuance of common stock upon the exercise of warrants | ||||||
0 | 45 | 12 | 0 | |||
Repurchase of convertible preferred stock | ||||||
0 | 0 | 5,335 | 0 | |||
Repurchase of common stock | ||||||
0 | 172 | 7,222 | 100 | |||
Proceeds from public offerings of common stock | ||||||
350,432 | 254,006 | 0 | - | |||
Proceeds from initial public offering, net of underwriting discounts and commissions | ||||||
- | - | - | 0 | |||
Payment of offering costs related to initial public offering and follow-on offering | ||||||
723 | 4,386 | 0 | 0 | |||
Net proceeds from issuance of equity interests in redeemable noncontrolling interest | ||||||
0 | 41,000 | 0 | 0 | |||
Net cash provided by financing activities | ||||||
367,304 | 293,161 | 281,656 | 39,840 | |||
Net effect of foreign exchange rate changes on cash, cash equivalents, and restricted cash | ||||||
84 | 0 | 0 | - | |||
Net increase in cash and cash equivalents | ||||||
2,684 | 67,948 | 39,005 | 29,332 | |||
Supplemental Disclosures of Cash Flow Information: | ||||||
Operating lease liabilities arising from obtaining right-of-use assets | ||||||
16,714 | 0 | 0 | - | |||
Cash paid for interest | ||||||
1,181 | 1,251 | 1,339 | 2,243 | |||
Cash paid for income taxes | ||||||
298 | 102 | 26 | 14 | |||
Supplemental Disclosures of Noncash Investing and Financing Activities: | ||||||
Capitalized license fees financed through future royalty payment | ||||||
0 | 0 | 6,302 | 0 | |||
Increase in purchases of property and equipment included in accounts payable and accrued expenses | ||||||
3,296 | 897 | 591 | - | |||
Vesting of common stock exercised early | ||||||
95 | - | - | - | |||
Property and equipment acquired under capital leases | ||||||
- | - | - | 34 | |||
Property and equipment acquired under capital leases | ||||||
0 | 0 | 346 | 468 | |||
Conversion of convertible preferred stock to common stock upon initial public offering | ||||||
0 | 499,974 | 0 | 0 | |||
Deferred offering costs included in accounts payable and accrued expenses | ||||||
0 | 89 | 0 | 0 | |||
Common Stock | ||||||
Payments for Repurchase of Common Stock | ||||||
- | - | - | 194 | |||
Vesting of common stock exercised early | ||||||
95 | 0 | 103 | - | |||
Stock issued | ||||||
- | - | - | 283 | |||
Convertible Preferred Stock | ||||||
Issuance of Series D convertible preferred stock in exchange for a technology license agreement | ||||||
0 | 0 | 1,060 | - | |||
Stock issued | ||||||
- | - | - | 0 | |||