| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||||||||||||||||||
Net loss | ||||||||||||||||||||||||
-7,662 | -14,726 | -13,251 | -15,829 | -14,083 | -13,906 | -11,575 | -11,278 | -11,512 | -9,257 | -7,950 | -8,141 | -7,931 | -8,328 | -7,854 | -8,071 | -7,554 | -8,881 | -7,168 | 10,389 | -7,109 | -7,393 | -6,617 | 7,991 | -5,101 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||||||||||
Depreciation | ||||||||||||||||||||||||
68 | 67 | 69 | 71 | 70 | 68 | 68 | 69 | 68 | 69 | 70 | 69 | 54 | 50 | 45 | 46 | 47 | 49 | 51 | 46 | 44 | 44 | 40 | 38 | 34 |
Non-cash lease expense | ||||||||||||||||||||||||
164 | 160 | 156 | 153 | 149 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Stock-based compensation expense | ||||||||||||||||||||||||
1,822 | 1,726 | 1,587 | 1,519 | 1,382 | 1,149 | 1,171 | 1,150 | 1,115 | 964 | 962 | 991 | 842 | 726 | 739 | 771 | 727 | 644 | 632 | 458 | 587 | 482 | 441 | 418 | 292 |
Changes in assets and liabilities: | ||||||||||||||||||||||||
Prepaid expenses and other current assets | ||||||||||||||||||||||||
-2,267 | 416 | 1,608 | -527 | 561 | -253 | -878 | 6 | 182 | 2,279 | 513 | -194 | 218 | -761 | -209 | 765 | 241 | -276 | 183 | -242 | -139 | 328 | -293 | 162 | -1,854 |
Accounts payable | ||||||||||||||||||||||||
1,698 | 28 | -1,619 | 1,195 | -832 | 2,004 | -2,580 | -614 | 1,206 | 995 | 1,056 | 72 | -1,063 | 318 | -134 | -190 | 1,007 | -68 | -463 | -77 | 299 | 290 | 111 | -1,324 | 652 |
Accrued expenses | ||||||||||||||||||||||||
-2,059 | 465 | 1,400 | 1,144 | -300 | 318 | 1,970 | -850 | -887 | 599 | 156 | 716 | -748 | 618 | -456 | 555 | -3,221 | 965 | 565 | 2,799 | -2,637 | 1,474 | 1,001 | 2,275 | -292 |
Noncurrent accrued expenses | ||||||||||||||||||||||||
393 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Operating lease liabilities | ||||||||||||||||||||||||
-191 | -98 | -183 | -176 | -171 | - | -17 | -17 | -17 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Deferred rent | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | -16 | -12 | -11 | 2 | -100 | 41 | 630 | 6 | 57 | 120 | -1 | -29 | - | - | 25 | 25 |
Net cash used in operating activities | ||||||||||||||||||||||||
-3,500 | -12,792 | -13,448 | -11,394 | -14,347 | -9,980 | -10,084 | -13,058 | -10,208 | -8,368 | -6,229 | -6,107 | -9,061 | -5,954 | -7,472 | -7,074 | -9,229 | -6,957 | 13,563 | -6,143 | -8,705 | -6,154 | -4,753 | 9,213 | -2,587 |
Investing activities | ||||||||||||||||||||||||
Purchases of property and equipment | ||||||||||||||||||||||||
8 | 12 | 18 | 74 | 39 | 57 | 26 | 25 | 16 | 34 | 32 | 164 | 62 | 438 | 225 | 22 | 17 | 3 | 58 | 204 | 2 | 14 | 102 | 81 | 13 |
Net cash used in investing activities | ||||||||||||||||||||||||
-8 | -12 | -18 | -74 | -39 | -57 | -26 | -25 | -16 | -34 | -32 | -164 | -62 | -438 | -225 | -22 | -17 | -3 | -58 | -204 | -2 | -14 | -102 | -81 | -13 |
Financing activities | ||||||||||||||||||||||||
Proceeds from issuance of common stock, net of issuance costs | ||||||||||||||||||||||||
- | - | - | - | - | 0 | 0 | -208 | 128,634 | 19,302 | -136 | 90,737 | 3,668 | 1,148 | -135 | 21,350 | 1,238 | - | - | - | - | 0 | 0 | -8 | 57,256 |
Proceeds from exercise of stock options | ||||||||||||||||||||||||
129 | 119 | 186 | 75 | 30 | 125 | 504 | 94 | 298 | 152 | 123 | 92 | 5 | 4 | 30 | 2 | 35 | 3 | 20 | 15 | 75 | - | - | - | - |
Net cash provided by financing activities | ||||||||||||||||||||||||
129 | 119 | 186 | 75 | 30 | 125 | 504 | -113 | 128,932 | 19,455 | -12 | 90,829 | 3,673 | 1,152 | -105 | 21,353 | 1,274 | 3 | 20 | 15 | 75 | 6 | 0 | 119 | 57,256 |
Net change in cash and cash equivalents | ||||||||||||||||||||||||
-3,378 | -12,685 | -13,280 | -11,393 | -14,356 | -9,911 | -9,606 | -13,197 | 118,707 | 11,052 | -6,275 | 84,557 | -5,451 | -5,240 | -7,802 | 14,255 | -7,972 | -6,957 | 13,525 | -6,332 | -8,632 | -6,163 | -4,855 | 9,251 | 54,655 |
Non-cash investing and financing activities | ||||||||||||||||||||||||
Property acquisition costs included in accrued expenses | ||||||||||||||||||||||||
- | - | - | - | 35 | - | - | - | - | - | - | - | 9 | - | - | - | - | - | - | 0 | 10 | - | - | - | - |
Issuance costs associated with financing included in accrued expenses | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | 198 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Issuance costs associated with the at-the-market financing included in accounts payable and accrued expenses | ||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 150 | - | - | - | - | - | - | - | - |