| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 |
|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||
Net loss | ||||||||
-102,630 | -94,433 | -84,068 | -75,108 | -69,408 | -64,775 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||
Depreciation and amortization | ||||||||
5,335 | 4,745 | 4,379 | 4,209 | 4,088 | 3,961 | 0 | 0 | 0 |
Net amortization of premiums and discounts on marketable securities | ||||||||
908 | 1,349 | 1,596 | 1,342 | 968 | 552 | 0 | 0 | 0 |
Stock-based compensation | ||||||||
5,911 | 5,299 | 5,177 | 4,146 | 3,648 | 2,995 | 0 | 0 | 0 |
Non-cash operating lease expense | ||||||||
6,888 | 6,382 | 0 | 0 | 0 | - | - | - | - |
Changes in operating assets and liabilities: | ||||||||
Prepaid expenses and other current assets | ||||||||
709 | -37 | 1,091 | 1,928 | 962 | 1,781 | 0 | 0 | 0 |
Deposits and other long-term assets | ||||||||
0 | - | - | - | 0 | - | - | - | - |
Accounts payable | ||||||||
1,145 | 45 | 4,670 | 2,559 | 3,656 | 3,249 | 0 | 0 | 0 |
Accrued compensation | ||||||||
1,082 | 650 | 1,325 | 829 | 653 | 1,724 | 0 | 0 | 0 |
Accrued and other non-current liabilities | ||||||||
-133 | 9 | -184 | 1,495 | 394 | -582 | 0 | 0 | 0 |
Accrued research and development expenses | ||||||||
0 | - | - | - | - | - | - | - | - |
Deferred rent | ||||||||
- | - | - | - | - | -396 | 0 | 0 | 0 |
Lease liability | ||||||||
174 | 54 | 0 | 0 | 0 | - | - | - | - |
Deferred revenue | ||||||||
-3,867 | -4,297 | 0 | 0 | 0 | - | - | - | - |
Net cash used in operating activities | ||||||||
-88,861 | -85,011 | -75,555 | -48,634 | -42,229 | -38,162 | 0 | 0 | 0 |
Investing activities | ||||||||
Purchase of marketable securities | ||||||||
75,192 | 80,979 | 0 | 0 | 0 | - | - | - | - |
Maturities of marketable securities | ||||||||
0 | - | - | - | 0 | - | - | - | - |
Sales of marketable securities | ||||||||
0 | - | - | - | - | - | - | - | - |
Maturities of marketable securities | ||||||||
- | - | - | - | - | 48,720 | 0 | 0 | 0 |
Purchase of property and equipment | ||||||||
15,204 | 16,173 | 12,863 | 7,637 | 6,549 | 5,663 | 0 | 0 | 0 |
Net cash provided by investing activities | ||||||||
29,185 | 15,841 | -34,271 | -53,259 | -63,451 | -59,103 | 0 | 0 | 0 |
Financing activities | ||||||||
Proceeds from issuance of common stock, net of issuance costs | ||||||||
80,775 | 75,202 | 163,191 | 162,994 | 92,663 | 92,586 | 0 | 0 | 0 |
Payments of deferred financing costs | ||||||||
0 | - | - | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||
79,964 | 74,395 | 160,832 | 172,080 | 110,518 | 110,441 | 0 | 0 | 0 |
Net decrease in cash, cash equivalents and restricted cash | ||||||||
20,288 | 5,225 | 0 | 0 | 0 | - | - | - | - |
Net decrease in cash, cash equivalents and restricted cash | ||||||||
- | - | - | - | - | - | - | - | 0 |
Supplemental disclosures of non-cash investing and financing information | ||||||||
Property and equipment purchases accrued but not yet paid | ||||||||
1,665 | 1,232 | 4,886 | 4,010 | 1,667 | 1,482 | 0 | 0 | 0 |
Remeasurement of operating lease right-of-use asset for lease modification | ||||||||
- | - | - | - | 0 | - | - | - | - |