| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenues: | ||||||||||
Total revenues | ||||||||||
195,992 | 151,862 | 316,613 | 146,691 | 135,057 | 75,334 | 54,799 | 42,325 | 56,086 | 13,624 | 13,671 |
Operating expenses: | ||||||||||
Cost of product sales | ||||||||||
45,546 | 10,136 | 31,152 | 33,206 | 29,245 | 22,732 | 6,246 | 1,094 | 257 | 985 | 311 |
Research and development | ||||||||||
140,804 | 150,252 | 150,643 | 150,842 | 93,236 | 79,696 | 96,640 | 70,044 | 57,563 | 51,773 | 56,614 |
Selling, general and administrative | ||||||||||
77,252 | 60,804 | 53,816 | 45,853 | 40,028 | 35,942 | 32,347 | 24,812 | 18,104 | 15,122 | 15,203 |
Total operating expenses | ||||||||||
263,602 | 221,192 | 235,611 | 229,901 | 162,509 | 138,370 | 135,233 | 95,950 | 75,925 | 67,881 | 72,129 |
Operating (loss) income | ||||||||||
-67,610 | -69,330 | 81,002 | -83,210 | -27,452 | -63,036 | -80,434 | -53,625 | -19,838 | -54,257 | -58,458 |
Other income (expense): | ||||||||||
Interest income, net | ||||||||||
- | - | - | - | - | - | - | - | - | 49 | 100 |
Other Income, net | ||||||||||
- | - | - | - | - | - | - | - | - | 966 | -3 |
Investment and other income, net | ||||||||||
6,986 | 7,578 | 2,592 | 1,326 | 422 | 242 | 229 | 73 | 69 | 1,015 | 97 |
Interest expense | ||||||||||
11,627 | 18,041 | 21,984 | 19,977 | 5,201 | 5,581 | 3,274 | 0 | 0 | - | - |
Net (loss) income before income taxes | ||||||||||
-72,251 | -79,793 | 61,610 | -101,861 | -32,231 | -68,375 | - | - | - | - | - |
Income tax expense | ||||||||||
-11 | 537 | -1,361 | 1,162 | 0 | 0 | - | - | - | - | - |
Net Income (Loss) Attributable to Parent | ||||||||||
-72,240 | -80,330 | 62,971 | -103,023 | -32,231 | -68,375 | -83,479 | -53,552 | -19,769 | -53,241 | -58,360 |
Net (loss) income per share: | ||||||||||
Basic and diluted (usd per share) | ||||||||||
-0.50 | -0.56 | - | - | - | -0.56 | -0.74 | -0.48 | -0.19 | -0.56 | -0.67 |
Net income (loss) per share, Basic | ||||||||||
- | - | 0.46 | -0.81 | -0.25 | - | - | - | - | - | - |
Net income (loss) per share, Diluted | ||||||||||
-0.50 | -0.56 | 0.45 | -0.81 | -0.25 | - | - | - | - | - | - |
Shares used in computing net (loss) income per share: | ||||||||||
Basic and diluted (in shares) | ||||||||||
144,329 | 143,599 | - | - | - | 122,690 | 112,805 | 111,077 | 102,566 | 94,357 | 86,700 |
Shares used in computing basic net income (loss) per share | ||||||||||
144,329 | 143,599 | 136,419 | 127,964 | 126,704 | - | - | - | - | - | - |
Shares used in computing diluted net income (loss) per share | ||||||||||
144,329 | 143,599 | 139,068 | 127,964 | 126,704 | - | - | - | - | - | - |
Comprehensive Loss | ||||||||||
- | - | - | - | - | - | - | - | - | -53,241 | - |
Royalties | ||||||||||
Total revenues | ||||||||||
69,899 | 78,981 | 63,507 | 50,984 | 30,975 | 9,425 | 33 | 0 | - | - | - |
Product sales, net | ||||||||||
Total revenues | ||||||||||
66,048 | 28,234 | 50,396 | 53,392 | 46,082 | 37,823 | 24,439 | 2,887 | 1,836 | 895 | 970 |
Collaborative Agreements [Member] | ||||||||||
Total revenues | ||||||||||
60,045 | 44,647 | 202,710 | 42,315 | 58,000 | 28,086 | 30,327 | 39,438 | 54,250 | 12,728 | 12,700 |