| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenues: | ||||||||||
Net product sales | ||||||||||
146,000 | 77,500 | 30,767 | 1,279 | 0 | 0 | - | - | - | - | - |
Contract revenue | ||||||||||
- | - | - | - | - | - | - | - | 646 | 1,301 | 1,261 |
Cost of product sales | ||||||||||
61,619 | 27,512 | 4,588 | 35 | 0 | 0 | - | - | - | - | - |
Research and development | ||||||||||
167,382 | 140,032 | 138,582 | 103,125 | 61,183 | 54,833 | 32,516 | 15,174 | 8,207 | 7,264 | 7,796 |
General and administrative | ||||||||||
37,897 | 29,263 | 25,554 | 21,366 | 18,395 | 11,020 | 21,941 | 8,657 | 3,501 | 3,971 | 3,707 |
Sales and marketing | ||||||||||
89,764 | 64,604 | 56,601 | 47,668 | 17,347 | 8,708 | - | - | - | - | - |
Total operating expenses | ||||||||||
356,662 | 261,411 | 225,325 | 172,194 | 96,925 | 74,561 | 54,457 | 23,831 | 11,708 | 11,235 | 11,503 |
Loss from operations | ||||||||||
-210,694 | -183,937 | -194,558 | -170,915 | -96,925 | -74,561 | -54,457 | -23,831 | -11,062 | -9,934 | -10,242 |
Other income (expense), net: | ||||||||||
Interest income | ||||||||||
7,259 | 5,965 | 1,049 | 445 | 174 | - | - | - | - | - | - |
Interest expense | ||||||||||
1,472 | 2,672 | 3,937 | 2,664 | 958 | 887 | 828 | 605 | -373 | -2 | 29 |
Gain on sale of royalty interest | ||||||||||
- | - | - | - | - | - | - | - | - | 2,500 | 0 |
Other income, net | ||||||||||
158 | 1,804 | -38 | -9 | 118 | -919 | 2 | 6 | - | 240 | 5 |
Total other income (expense), net | ||||||||||
5,945 | 5,097 | -2,926 | -2,228 | -666 | -1,806 | -826 | -599 | - | 2,738 | 24 |
Income tax benefit | ||||||||||
- | - | - | - | - | - | - | - | - | - | -122 |
Loss from continuing operations | ||||||||||
- | - | - | - | - | - | - | -24,430 | -11,435 | -7,196 | -10,096 |
Gain from discontinued operations | ||||||||||
- | - | - | - | - | - | - | 1,082 | -379 | - | - |
Loss from continuing operations | ||||||||||
- | - | - | - | - | - | - | - | - | - | -10,218 |
Loss from discontinued operations | ||||||||||
- | - | - | - | - | - | - | - | - | -150 | 68 |
Net loss | ||||||||||
-204,749 | -178,840 | -197,484 | -173,143 | -97,591 | -76,367 | -55,283 | -23,348 | -11,814 | -7,346 | -10,028 |
Other comprehensive income: | ||||||||||
Unrealized gains on short-term investments | ||||||||||
172 | -77 | 7 | 23 | -40 | 0 | 0 | - | - | - | - |
Comprehensive loss | ||||||||||
-204,577 | -178,917 | -197,477 | -173,120 | -97,631 | -76,367 | -55,283 | - | - | - | - |
Loss from continuing operations (in Dollars per share) | ||||||||||
- | - | - | - | - | - | - | -2.00 | -1.90 | -0.18 | -0.31 |
Basic and diluted net loss per share | ||||||||||
-2.50 | -2.44 | -3.65 | -4.56 | -2.95 | -2.87 | -3.42 | -1.91 | -1.96 | -0.19 | -0.31 |
Shares used in computing basic and diluted net loss per share | ||||||||||
81,779 | 73,193 | 54,040 | 37,925 | 33,081 | 26,569 | 16,163 | 12,223 | 6,013 | - | - |
Weighted-average common shares used to compute basic and diluted net loss per share | ||||||||||
- | - | - | - | - | - | - | - | - | 39,671 | 32 |