| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 |
|---|---|---|---|---|---|---|---|---|---|
CASH FLOWS FROM OPERATING ACTIVITIES: | |||||||||
Net loss | |||||||||
573,020 | -38,380 | -350,125 | -165,563 | 39,532 | -263,603 | -149,005 | -87,794 | -113,265 | -27,065 |
Adjustments to reconcile net loss to net cash (used in) provided by operating activities: | |||||||||
Depreciation and amortization expense | |||||||||
237,157 | 249,759 | 256,087 | 221,665 | 138,343 | 34,009 | 9,310 | 5,538 | 4,199 | 2,973 |
Equity-settled share-based compensation | |||||||||
91,215 | 114,860 | 125,019 | 113,019 | 83,553 | 13,198 | 5,014 | 4,661 | 2,530 | 2,574 |
Payments related to term loan refinancing | |||||||||
- | - | - | - | 3,000 | - | - | - | - | - |
Amortization of debt discount and deferred financing costs | |||||||||
22,602 | 22,751 | 21,619 | 18,546 | 18,810 | 9,273 | 4,364 | 2,740 | 2,708 | - |
Intangible impairment charge | |||||||||
- | - | - | - | - | - | - | - | 69,621 | - |
Non-cash interest expense and amortization of deferred charges | |||||||||
- | - | - | - | - | - | - | - | - | 966 |
Paid-in-kind interest expense | |||||||||
- | - | - | - | - | - | 2,225 | 2,607 | - | - |
Loss on induced conversions of debt and debt extinguishment | |||||||||
- | - | - | - | -21,581 | -11,709 | -12,881 | - | - | - |
Loss on debt extinguishment | |||||||||
-58,835 | - | -978 | - | - | - | - | - | - | - |
Foreign exchange loss | |||||||||
- | - | - | - | - | - | 1,206 | 489 | -1,023 | -273 |
Loss (gain) on sale of assets | |||||||||
-10,963 | 42,985 | - | - | - | - | - | -76 | - | -42 |
Loss on derivative revaluation | |||||||||
- | - | - | - | - | 214,995 | 69,300 | - | - | - |
Bargain purchase gain | |||||||||
- | - | - | - | - | 22,171 | - | - | - | 19,326 |
Deferred income taxes | |||||||||
565,537 | 64,491 | 132,231 | 65,561 | 180,549 | 7,516 | 1,186 | 5,206 | - | - |
Royalty accretion | |||||||||
- | - | - | 40,616 | 20,088 | 9,020 | - | - | - | - |
Impairment of long-lived assets | |||||||||
- | 46,096 | 22,270 | 71,260 | - | - | - | - | - | - |
Royalty liability remeasurement | |||||||||
- | - | - | -713 | 21,151 | 10,660 | - | - | - | - |
Gain on divestiture | |||||||||
- | - | 1,236 | - | - | - | - | - | - | - |
Acquired in-process research and development expense | |||||||||
- | - | 159,171 | - | - | - | - | - | - | - |
Loss on sale of long-term investments | |||||||||
- | - | - | - | -29,032 | 0 | 0 | - | - | - |
Foreign exchange and other adjustments | |||||||||
-574 | -332 | 1,466 | -420 | -1,495 | -3,916 | - | - | - | - |
Changes in operating assets and liabilities: | |||||||||
Accounts receivable | |||||||||
-56,166 | 59,697 | 84,444 | 68,271 | 124,766 | 46,183 | 12,491 | 1,087 | 1,817 | 516 |
Inventories | |||||||||
3,268 | -10,280 | -108,371 | -67,633 | -12,216 | -7,173 | 3,426 | 4,022 | 923 | -1,010 |
Prepaid expenses and other current assets | |||||||||
72,763 | 25,313 | -5,110 | 28,239 | -1,014 | 9,208 | 1,240 | 543 | 1,897 | -551 |
Accounts payable | |||||||||
-8,723 | -4,593 | -16,521 | 32,065 | -8,362 | 9,383 | 3,908 | -2,209 | 5,643 | -1,137 |
Accrued trade discounts and rebates | |||||||||
8,591 | -44,028 | 205,487 | - | - | - | 6,962 | 7,260 | - | - |
Accrued expenses | |||||||||
19,788 | 40,787 | -43,937 | - | - | - | 980 | -208 | 3,215 | -2,404 |
Deferred revenues | |||||||||
-4,901 | -395 | 4,468 | 1,114 | 1,693 | -562 | -1,145 | 2,616 | 3,237 | 5,734 |
Deferred tax liabilities | |||||||||
- | - | - | - | - | - | - | - | -15,778 | -708 |
Other non-current assets and liabilities | |||||||||
-2,613 | 10,440 | -5,720 | -4,455 | -8,120 | -636 | -468 | 581 | 36 | 499 |
Net cash (used in) provided by operating activities | |||||||||
426,332 | 194,543 | 284,340 | 369,456 | 194,166 | 27,549 | -54,287 | -76,641 | -41,540 | -37,532 |
CASH FLOWS FROM INVESTING ACTIVITIES: | |||||||||
Change in escrow deposit for property purchase | |||||||||
6,000 | - | - | - | - | - | - | - | - | - |
Payment related to license agreement | |||||||||
- | 12,000 | - | - | - | - | - | - | - | - |
Payments for acquisitions, net of cash acquired | |||||||||
- | - | 167,220 | 1,354,921 | 1,022,361 | 224,220 | 35,000 | - | - | - |
Proceeds from divestiture, net of cash divested | |||||||||
- | - | 69,371 | - | - | - | - | - | - | - |
Proceeds from the settlement of capped call transactions | |||||||||
- | - | - | - | - | 9,385 | - | - | - | - |
Proceeds from sale of assets | |||||||||
6,000 | 44,424 | - | - | - | - | - | - | - | - |
Purchases of property and equipment | |||||||||
17,857 | 4,771 | 4,336 | 15,725 | 7,156 | 3,500 | 1,198 | 1,336 | 1,604 | 714 |
Acquisition of Nitec Pharma AG, net of cash acquired | |||||||||
- | - | - | - | - | - | - | - | - | 6,489 |
Net cash used in investing activities | |||||||||
-17,857 | 27,653 | -102,185 | -1,370,646 | -995,048 | -227,720 | -36,135 | -1,386 | -2,154 | 5,575 |
CASH FLOWS FROM FINANCING ACTIVITIES: | |||||||||
Contingent consideration proceeds from divestiture | |||||||||
3,297 | - | - | - | - | - | - | - | - | - |
Payment of contingent consideration | |||||||||
- | - | 20,000 | - | - | - | - | - | - | - |
Repurchase of ordinary shares | |||||||||
- | - | 992 | - | - | - | - | - | - | - |
Proceeds from the issuance of debt, net of underwriting fees and issuance costs | |||||||||
- | - | - | - | - | - | - | 55,578 | - | - |
Proceeds from the issuance of ordinary shares in connection with warrant exercises | |||||||||
- | - | 1,789 | 8 | 18,124 | 38,461 | - | 154 | - | - |
Proceeds from the issuance of ordinary shares in conjunction with ESPP program | |||||||||
11,317 | 8,610 | 7,082 | 6,540 | 4,452 | 1,674 | 639 | - | - | - |
Proceeds from the issuance of ordinary shares in connection with stock option exercises | |||||||||
24,882 | 16,972 | 2,167 | 3,875 | 5,217 | 2,693 | - | 287 | - | - |
Payment of employee withholding taxes relating to share-based awards | |||||||||
31,569 | 14,455 | 6,533 | 5,539 | 3,024 | 894 | - | - | - | - |
Net proceeds from the issuance of senior notes | |||||||||
590,057 | - | - | - | - | - | - | - | - | - |
Repayment of notes payable | |||||||||
- | - | - | - | - | - | 64,844 | 19,788 | 13,067 | 10,981 |
Purchase of capped calls | |||||||||
- | - | - | - | - | - | 18,675 | - | - | - |
Net proceeds from the issuance of ordinary shares | |||||||||
326,793 | - | - | - | 475,685 | - | 5,998 | - | 124 | - |
Change in restricted cash | |||||||||
- | - | - | - | 1,122 | - | -63 | 50 | 550 | 200 |
Proceeds from liquidation of available-for-sale investments | |||||||||
- | - | - | - | 64,623 | - | - | - | - | - |
Purchases of long-term investments | |||||||||
- | - | - | - | 71,813 | - | - | - | - | - |
Proceeds from sale of long-term investments | |||||||||
- | - | - | - | 42,781 | - | - | - | - | - |
Repayment of senior notes | |||||||||
814,420 | - | - | - | - | - | - | - | - | - |
Net proceeds from term loans | |||||||||
935,404 | 818,026 | 1,693,512 | 364,297 | 391,506 | - | - | - | - | - |
Repayment of term loans | |||||||||
1,336,207 | 845,749 | 1,622,749 | 4,000 | 299,000 | - | - | - | - | - |
Proceeds from issuance of common stock in initial public offering, net of underwriting fees and issuance costs | |||||||||
- | - | - | - | - | - | - | - | 44,678 | - |
Proceeds from issuance of bridge notes payable to related parties | |||||||||
- | - | - | - | - | - | - | - | 6,766 | 10,000 |
Proceeds from issuance of convertible preferred stock, net of issuance costs | |||||||||
- | - | - | - | - | - | - | - | - | 20,683 |
Proceeds from equity finance offerings, net of offering costs | |||||||||
- | - | - | - | - | - | - | 128,077 | - | - |
Proceeds from the issuance of notes payable | |||||||||
- | - | - | - | - | - | - | - | 16,651 | 10,058 |
Net cash (used in) provided by financing activities | |||||||||
-290,446 | -16,596 | 54,276 | 657,074 | 1,442,481 | 338,285 | 66,716 | 164,308 | 55,152 | 29,760 |
Effect of foreign exchange rate changes on cash, cash equivalents and restricted cash | |||||||||
-107 | -1,380 | 5,316 | -1,210 | -790 | 213 | 99 | -160 | 1,124 | 421 |
Net (decrease) increase in cash, cash equivalents and restricted cash | |||||||||
117,922 | 204,220 | 241,747 | -345,326 | 640,809 | 138,327 | -23,607 | 86,121 | 12,582 | -1,776 |
SUPPLEMENTAL CASH FLOW INFORMATION: | |||||||||
Cash paid for interest | |||||||||
78,044 | 112,468 | 113,790 | 60,817 | 42,021 | 14,109 | 8,573 | 7,554 | 2,757 | 1,905 |
Cash paid for income taxes, net of refunds received | |||||||||
9,925 | 53,058 | 2,548 | 22,339 | 1,880 | 37 | 44 | 57 | - | 66 |
Cash paid for amounts included in the measurement of lease liabilities, net of lease incentive payments | |||||||||
6,484 | - | - | - | - | - | - | - | - | - |
Cash paid for debt extinguishment | |||||||||
- | - | - | - | 45,367 | - | - | 2,124 | 440 | - |
Fees paid for debt commitments | |||||||||
- | - | - | - | 9,000 | 8,222 | - | - | - | - |
Cash paid for induced conversions | |||||||||
- | - | - | - | 10,005 | 16,690 | 12,152 | - | - | - |
SUPPLEMENTAL NON-CASH FLOW INFORMATION: | |||||||||
Goodwill and other intangible assets acquired in acquisitions | |||||||||
- | - | - | - | - | - | 67,705 | - | - | - |
Contingent liabilities assumed in acquisitions | |||||||||
- | - | - | - | - | - | 32,992 | - | - | - |
Purchases of property and equipment included in accounts payable and accrued expenses | |||||||||
117 | 1,101 | - | 700 | 4,940 | 1,463 | - | - | - | - |
Lease liabilities arising from obtaining right-of-use assets | |||||||||
11,444 | - | - | - | - | - | - | - | - | - |
Purchases of acquired in-process research and development included in accounts payable and accrued expenses | |||||||||
- | - | 12,000 | - | - | - | - | - | - | - |
Conversion of Convertible Senior Notes to ordinary shares | |||||||||
- | - | - | - | 60,985 | 89,015 | - | - | - | - |
Commitment fee paid on notes payable | |||||||||
- | - | - | - | - | - | - | - | - | 120 |
Convertible preferred stock and common stock issued to Nitec shareholders in connections with in connection with the Nitec acquisition | |||||||||
- | - | - | - | - | - | - | - | - | 104,135 |
Accrued Trade Discounts and Rebates [Member] | |||||||||
Accrued liabilities | |||||||||
- | - | - | 112,381 | - | - | - | - | - | - |
Accrued Expenses and Accrued Royalties [Member] | |||||||||
Accrued liabilities | |||||||||
- | - | - | 14,629 | - | - | - | - | - | - |
2024 Senior Notes [Member] | |||||||||
Net proceeds from term loans | |||||||||
- | - | - | 291,893 | - | - | - | - | - | - |