| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Alliance revenue | ||||||||||
- | 662 | 902 | 16,199 | - | - | - | - | - | - | - |
Alliance revenue | ||||||||||
- | - | - | - | 249 | 73 | 47 | 51 | 53 | 16,110 | 34,518 |
Operating expenses: | ||||||||||
Research and development | ||||||||||
8,102 | 41,841 | 50,653 | 39,824 | 33,699 | 27,493 | 10,475 | 13,673 | 17,969 | 24,226 | 18,570 |
General and administrative | ||||||||||
3,143 | 15,420 | 15,588 | 15,132 | 15,396 | 11,332 | 7,741 | 6,279 | 7,939 | 9,867 | 8,561 |
Merger-related costs, net | ||||||||||
- | 1,245 | 1,128 | - | - | - | - | - | - | - | - |
Restructuring costs | ||||||||||
131 | 3,112 | - | - | - | - | - | - | - | - | - |
Total operating expenses | ||||||||||
11,376 | 61,618 | 67,369 | 54,956 | 49,095 | 38,825 | 18,216 | 19,952 | 25,908 | 34,093 | 27,131 |
Loss from operations | ||||||||||
-11,376 | -60,956 | -66,467 | -38,757 | -48,846 | -38,752 | -18,169 | -19,901 | -25,855 | -17,983 | 7,387 |
Other income (expense): | ||||||||||
Interest income | ||||||||||
404 | 1,089 | 574 | 415 | 357 | 66 | 11 | - | - | - | - |
Interest expense | ||||||||||
- | 11 | 50 | 80 | 105 | 27 | - | - | - | 2 | 3 |
Decrease in fair value of warrant liability | ||||||||||
- | - | - | - | - | - | - | 675 | 1,974 | - | - |
Investment income | ||||||||||
- | - | - | - | - | - | - | 9 | 30 | 116 | 145 |
Foreign currency exchange gain (loss) | ||||||||||
-2 | -3 | -41 | 33 | 39 | 71 | -68 | -23 | 75 | -94 | -27 |
(Loss) income before income taxes | ||||||||||
- | - | - | - | - | - | - | - | - | - | 7,502 |
Income tax benefit | ||||||||||
- | - | - | - | - | - | - | - | - | - | -44 |
Net income (loss) | ||||||||||
-10,974 | -59,881 | -65,984 | -38,389 | -48,555 | -39,161 | -18,226 | -19,240 | -23,776 | -17,963 | 7,546 |
Net income (loss) per share applicable to common stockholders (Note 12) | ||||||||||
Basic | ||||||||||
-0.40 | - | - | - | - | - | - | - | - | -0.71 | 0.32 |
Diluted | ||||||||||
-0.40 | - | - | - | - | - | - | - | - | -0.71 | 0.31 |
Weighted-average number of common shares used in computing net income (loss) per share applicable to common stockholders | ||||||||||
Basic | ||||||||||
27,676 | - | - | - | - | - | - | - | - | 25,139 | 23,420 |
Diluted | ||||||||||
27,676 | - | - | - | - | - | - | - | - | 25,139 | 24,079 |
Net loss | ||||||||||
- | - | - | - | -48,555 | -38,642 | - | - | - | - | - |
Deemed dividend related to December 2019 Private Placement (see Note 7) | ||||||||||
- | - | - | - | - | 519 | 2,866 | 3,210 | 4,548 | - | - |
Net loss attributable to common stockholders | ||||||||||
- | -59,881 | -65,984 | -38,389 | -48,555 | -38,642 | -21,092 | -22,450 | -28,324 | -17,963 | 7,546 |
Net loss per share applicable to common stockholders - basic and diluted (Note 17) | ||||||||||
- | -2.25 | -3.35 | -2.41 | -0.42 | -0.47 | -0.48 | -0.81 | -1.03 | - | - |
Weighted-average number of common shares used in computing net loss per share applicable to common stockholders - basic and diluted | ||||||||||
- | 26,601 | 19,675 | 15,950 | 115,092 | 82,827 | 43,906 | 27,639 | 27,623 | - | - |
Comprehensive income (loss): | ||||||||||
Net income (loss) | ||||||||||
-10,974 | -59,881 | -65,984 | -38,389 | -48,555 | - | -18,226 | -19,240 | -23,776 | -17,963 | 7,546 |
Unrealized gain on available-for-sale securities | ||||||||||
2 | - | 17 | 117 | -117 | -10 | - | - | - | - | - |
Total other comprehensive income | ||||||||||
2 | - | 17 | 117 | -117 | -10 | -7 | - | - | - | - |
Unrealized gain (loss) on available-for-sale securities | ||||||||||
- | - | - | - | - | - | -7 | - | - | - | - |
Increase in unrealized loss and decrease in unrealized gain on available-for-sale securities | ||||||||||
- | - | - | - | - | - | - | - | -13 | 32 | - |
Other comprehensive loss | ||||||||||
- | - | - | - | - | - | - | - | -13 | - | - |
Other comprehensive income | ||||||||||
- | - | - | - | - | - | - | - | - | 32 | - |
Comprehensive income (loss): | ||||||||||
-10,972 | -59,881 | -65,967 | -38,272 | -48,672 | -38,652 | -18,233 | -19,240 | -23,789 | -17,931 | - |