| Dec'19 | Dec'18 | Dec'17 | Jan'17 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 |
|---|---|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | |||||||||||
Consolidated net income | |||||||||||
990,000 | 782,000 | 678,000 | 428,000 | 458,000 | 353,351 | 125,308 | 151,254 | 86,628 | 124,891 | 72,281 | 39,416 |
Adjustments to reconcile net income to net cash provided by operating activities: | |||||||||||
Depreciation expense | |||||||||||
151,000 | 140,000 | 110,000 | 90,000 | 73,000 | 61,905 | 50,810 | 48,249 | 55,575 | 34,204 | 24,504 | 17,285 |
Amortization of intangible assets | |||||||||||
37,000 | 39,000 | 46,000 | 51,000 | 54,000 | 50,669 | 47,115 | 17,070 | 13,617 | 7,805 | 6,680 | 10,438 |
Share-based compensation expense | |||||||||||
194,000 | 193,000 | 164,000 | 129,000 | 133,000 | 152,551 | 105,826 | 94,324 | 92,092 | 71,645 | 60,811 | 47,688 |
Accretion of debt discount | |||||||||||
46,000 | 41,000 | 30,000 | 30,000 | 39,000 | 38,069 | 36,237 | 35,004 | 32,173 | 21,407 | 20,286 | 18,883 |
Loss on extinguishment of debt | |||||||||||
- | - | - | - | - | -31,360 | -555 | - | -37,611 | - | 0 | - |
Contingent compensation expense | |||||||||||
- | - | - | - | - | - | - | 6,306 | 3,457 | - | 0 | - |
Incremental tax benefit related to share-based compensation | |||||||||||
- | - | - | - | - | 126,479 | 56,678 | 20,783 | 46,354 | 42,445 | 39,319 | 18,501 |
Deferred income taxes | |||||||||||
-11,000 | 18,000 | -81,000 | -94,000 | -81,000 | -99,846 | 36,663 | -21,698 | 19,227 | 48,696 | 29,704 | 31,533 |
Payment of accreted debt discount | |||||||||||
84,000 | 0 | 0 | - | - | - | - | - | - | - | - | - |
Marketable Securities, Unrealized Gain (Loss) | |||||||||||
53,000 | 21,000 | 0 | - | - | - | - | - | - | - | - | - |
Deconsolidation, Gain (Loss), Amount | |||||||||||
54,000 | 0 | 453,000 | - | - | - | - | - | - | - | - | - |
Loss on derivative assets related to terminated acquisition | |||||||||||
-8,000 | 0 | 0 | - | - | - | - | - | - | - | - | - |
Impairment of intangible assets | |||||||||||
- | - | 23,000 | - | - | - | 25,214 | 21,438 | - | - | 0 | - |
Change in fair value of contingent consideration | |||||||||||
- | - | - | - | - | -5,356 | -18,784 | 1,975 | -4,500 | 10,376 | 0 | - |
Change in estimated cease-use loss | |||||||||||
- | - | - | - | - | - | 2,624 | 22,367 | 23,638 | - | - | - |
Recovery of loan receivable previously impaired | |||||||||||
- | - | - | - | - | - | - | - | - | 0 | - | - |
Change in facility exit obligation | |||||||||||
- | - | - | - | - | - | - | - | - | - | 0 | - |
Cost-method investment gain, net | |||||||||||
- | - | - | - | 16,000 | 4,427 | 61,357 | 45,911 | - | -10,309 | - | - |
Gain on litigation settlement | |||||||||||
- | - | - | - | - | 109,363 | - | - | - | - | - | 54,536 |
Acquired in-process research and development | |||||||||||
- | - | - | - | - | - | - | - | - | - | 11,325 | 24,660 |
Impairment of manufacturing equipment | |||||||||||
- | - | - | - | - | - | - | - | - | - | - | 4,069 |
Other | |||||||||||
1,000 | -4,000 | -1,000 | -2,000 | -4,000 | -15,618 | -12,811 | -251 | -9,949 | -8,811 | -1,721 | 803 |
Changes in operating assets and liabilities: | |||||||||||
Accounts receivable | |||||||||||
58,000 | 105,000 | 26,000 | -3,000 | 96,000 | 50,381 | 15,928 | 34,441 | 7,011 | 7,844 | 18,578 | 57,672 |
Inventory | |||||||||||
-25,000 | 53,000 | 33,000 | 30,000 | 81,000 | 36,542 | -6,217 | 23,707 | -22,152 | 48,583 | 20,557 | 19,560 |
Prepaid expenses and other current assets | |||||||||||
14,000 | -5,000 | -8,000 | 1,000 | 11,000 | -6,619 | -1,783 | 3,062 | 2,016 | -2,554 | 3,429 | -2,322 |
Operating lease right-of-use assets and liabilities, net | |||||||||||
5,000 | - | - | - | - | - | - | - | - | - | - | - |
Other assets | |||||||||||
30,000 | 9,000 | 5,000 | 7,000 | 2,000 | 36,256 | 16,357 | 2,903 | 4,004 | 3,566 | 2,670 | 1,815 |
Accounts payable | |||||||||||
-35,000 | 45,000 | 10,000 | -2,000 | 46,000 | -2,106 | 2,389 | 15,112 | -21,097 | 23,150 | 11,778 | 4,840 |
Accrued liabilities | |||||||||||
-44,000 | 103,000 | 81,000 | -24,000 | 99,000 | 60,332 | 38,550 | 24,388 | 38,945 | 32,028 | 19,997 | 31,716 |
Accrued legal contingencies | |||||||||||
- | - | - | - | - | - | 132,933 | - | - | - | - | - |
Other long-term liabilities | |||||||||||
-33,000 | -4,000 | 160,000 | 16,000 | 5,000 | 1,861 | 3,816 | 6,640 | 8,058 | -113 | 814 | 6,313 |
Unrealized (gain) loss on foreign exchange | |||||||||||
- | - | - | - | - | - | - | - | - | - | 3,157 | - |
Net cash provided by operating activities | |||||||||||
1,051,000 | 1,142,000 | 875,000 | 779,000 | 786,000 | 501,271 | 386,421 | 291,873 | 358,140 | 272,573 | 172,191 | 87,882 |
Cash flows from investing activities: | |||||||||||
Maturities of available-for-sale securities | |||||||||||
1,387,000 | 860,000 | 321,000 | 140,000 | 294,000 | 150,229 | 289,197 | 400,379 | 492,444 | 149,450 | 203,990 | - |
Purchases of available-for-sale securities | |||||||||||
1,010,000 | 2,859,000 | 742,000 | 895,000 | 797,000 | 791,252 | 364,001 | 925,478 | 1,310,269 | 846,208 | 694,487 | 568,707 |
Sales of available-for-sale securities | |||||||||||
629,000 | 597,000 | 322,000 | 543,000 | 582,000 | 391,655 | 523,635 | 498,371 | 568,447 | 539,161 | 310,226 | - |
Deconsolidation of Helix and GRAIL cash | |||||||||||
29,000 | 0 | 52,000 | - | - | - | - | - | - | - | - | - |
Proceeds from the deconsolidation of GRAIL | |||||||||||
15,000 | - | 278,000 | - | - | - | - | - | - | - | - | - |
Cash paid for derivative assets related to terminated acquisition | |||||||||||
18,000 | 0 | 0 | - | - | - | - | - | - | - | - | - |
Proceeds from sale of strategic investment | |||||||||||
- | - | - | - | - | - | - | - | - | 0 | - | - |
Purchases of property and equipment | |||||||||||
209,000 | 296,000 | 310,000 | 260,000 | 143,000 | 105,996 | 79,215 | 68,781 | 77,800 | 49,818 | 52,673 | 59,693 |
Net purchases of strategic investments | |||||||||||
20,000 | 15,000 | 29,000 | 14,000 | 6,000 | 11,755 | -95,580 | -40,881 | 13,769 | 27,677 | 19,900 | - |
Sales and maturities of available-for-sale securities | |||||||||||
- | - | - | - | - | - | - | - | - | - | - | 411,817 |
Sales and maturities of trading securities | |||||||||||
- | - | - | - | - | - | - | - | - | 54,900 | 1,000 | - |
Net cash paid for acquisitions | |||||||||||
0 | 100,000 | 0 | 18,000 | 37,000 | 3,285 | 523,501 | 83,156 | 58,302 | 98,211 | 1,325 | 24,666 |
Cash paid for intangible assets | |||||||||||
- | - | 2,000 | 11,000 | - | 36,220 | 11,344 | 12,228 | 1,750 | 6,650 | 3,400 | 36,000 |
Net cash (used in) provided by investing activities | |||||||||||
745,000 | -1,813,000 | -214,000 | -515,000 | -107,000 | -406,624 | -69,649 | -150,012 | -400,999 | -285,053 | -256,569 | -277,249 |
Cash flows from financing activities: | |||||||||||
Payments on financing obligations | |||||||||||
550,000 | 4,000 | 9,000 | 66,000 | 245,000 | 29,991 | 10,852 | - | 349,874 | - | - | - |
Net proceeds from issuance of debt | |||||||||||
0 | 735,000 | 5,000 | 5,000 | - | 1,132,378 | - | - | - | - | - | - |
Proceeds from issuance of convertible notes | |||||||||||
- | - | - | - | - | - | - | - | 903,492 | 0 | 0 | - |
Repurchase of convertible notes | |||||||||||
- | - | - | - | - | 1,244,721 | - | - | - | 0 | 10,000 | 15 |
Incremental tax benefit related to share-based compensation | |||||||||||
- | - | - | - | - | 126,479 | 56,678 | 20,783 | 46,354 | 42,445 | 39,319 | 18,501 |
Payments for Repurchase of Common Stock | |||||||||||
324,000 | 201,000 | 251,000 | 249,000 | 274,000 | 237,183 | 50,020 | 82,522 | 570,406 | 44,016 | 175,136 | 70,785 |
Taxes paid related to net share settlement of equity awards | |||||||||||
82,000 | 74,000 | 68,000 | 100,000 | 127,000 | 10,038 | - | - | - | - | - | - |
Payments on retirement of warrants | |||||||||||
- | - | - | - | - | - | 125,000 | - | 5,512 | - | - | - |
Proceeds from the exercise of warrants | |||||||||||
- | - | - | - | - | - | - | - | - | 16,029 | 7,576 | 2,991 |
Proceeds from secondary offering, net of issuance cost | |||||||||||
- | - | - | - | - | - | - | - | - | - | - | 342,650 |
Proceeds from issuance of common stock | |||||||||||
59,000 | 46,000 | 71,000 | 47,000 | 72,000 | 96,328 | 94,460 | 54,358 | 61,938 | 102,016 | 39,379 | 44,330 |
Contributions from noncontrolling interest owners | |||||||||||
0 | 92,000 | 79,000 | 89,000 | 32,000 | - | - | - | - | - | - | - |
Payments on acquisition related contingent consideration liability | |||||||||||
- | - | 3,000 | 29,000 | 3,000 | - | 3,985 | 3,374 | 0 | 0 | - | - |
Proceeds from early exercise of equity awards from a subsidiary | |||||||||||
- | - | - | 7,000 | - | - | - | - | - | - | - | - |
Net cash used in financing activities | |||||||||||
-897,000 | 594,000 | -176,000 | -296,000 | -545,000 | -166,748 | -38,719 | -10,755 | 97,016 | 116,474 | -98,862 | 337,672 |
Effect of exchange rate changes on cash and cash equivalents | |||||||||||
-1,000 | -4,000 | 5,000 | -2,000 | -1,000 | -3,382 | -397 | -103 | -126 | 320 | 849 | 3,778 |
Net (decrease) increase in cash and cash equivalents | |||||||||||
898,000 | -81,000 | 490,000 | -34,000 | 133,000 | -75,483 | 277,656 | 131,003 | 54,031 | 104,314 | -182,391 | 152,083 |
Supplemental cash flow information: | |||||||||||
Cash paid for interest | |||||||||||
- | - | - | - | - | - | - | - | - | 2,437 | 2,437 | 2,553 |
Cash paid for income taxes | |||||||||||
164,000 | 99,000 | 149,000 | 60,000 | 17,000 | 17,886 | 50,086 | 74,037 | 9,806 | 31,566 | 10,361 | -1,653 |
Cash paid for operating lease liabilities | |||||||||||
84,000 | - | - | - | - | - | - | - | - | - | - | - |
Unsettled short-term investments purchase | |||||||||||
- | - | - | - | - | - | - | 9,154 | 0 | - | - | - |