| Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities | |||||||||||||||||||
Net loss | |||||||||||||||||||
-54,758 | -53,137 | -52,504 | -52,542 | -51,862 | -54,328 | -53,355 | -53,856 | -53,530 | -51,199 | -46,163 | -42,333 | -39,445 | -40,450 | -39,725 | -35,334 | -34,151 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | |||||||||||||||||||
Depreciation and amortization | |||||||||||||||||||
346 | 363 | 368 | 356 | 351 | 332 | 322 | 307 | 304 | 294 | 283 | 267 | 243 | 238 | 227 | 229 | 238 | 0 | 0 | 0 |
Amortization of premium/discount on investments | |||||||||||||||||||
561 | 502 | 374 | 202 | 26 | -201 | -210 | -200 | -126 | 30 | 28 | 48 | 0 | 0 | 0 | 0 | - | - | - | - |
Stock-based compensation | |||||||||||||||||||
7,276 | 8,084 | 8,430 | 9,124 | 8,633 | 8,977 | 9,154 | 9,195 | 9,283 | 8,753 | 7,834 | 7,401 | 6,297 | 4,917 | 3,934 | 2,388 | 1,344 | 0 | 0 | 0 |
Revaluation of convertible preferred stock warrant liability | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 4,277 | 0 | 0 | 0 |
Changes in operating assets and liabilities: | |||||||||||||||||||
Accounts receivable | |||||||||||||||||||
58 | 260 | 165 | -263 | 130 | -6,974 | 118 | 590 | -455 | 4,351 | -502 | -1,565 | -998 | 3,093 | -159 | 1,566 | 1,883 | 0 | 0 | 0 |
Inventory | |||||||||||||||||||
652 | 746 | 276 | 98 | 77 | -101 | -100 | -129 | 594 | 402 | 290 | 678 | -12 | -174 | 415 | 13 | 8 | 0 | 0 | 0 |
Prepaid expenses | |||||||||||||||||||
- | 0 | 0 | 0 | - | 0 | 0 | 0 | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Restricted cash | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Prepaid expenses | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | -537 | 457 | 454 | 0 | 0 | 0 |
Other assets | |||||||||||||||||||
-1,348 | -2,870 | -35 | -49 | -22 | 3,016 | 26 | 49 | 3,059 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Accounts payable | |||||||||||||||||||
-856 | 267 | -1,090 | -684 | -2,225 | -1,799 | 718 | 1,549 | 1,485 | 1,672 | 1,512 | -658 | -3,829 | -391 | 761 | 1,486 | 6,037 | 0 | 0 | 0 |
Accrued liabilities | |||||||||||||||||||
1,181 | 135 | -1,024 | -490 | 1,203 | 885 | -1,380 | 35 | 976 | 775 | 3,493 | 2,221 | -519 | 1,104 | 2,467 | 732 | 3,424 | 0 | 0 | 0 |
Accrued litigation-related settlement | |||||||||||||||||||
-6,000 | -7,250 | -7,250 | -7,250 | -1,250 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Deferred rent and other noncurrent liabilities | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | 500 | 500 | 507 | 0 | 0 | 0 |
Deferred rent and other liabilities | |||||||||||||||||||
- | 0 | 0 | 0 | - | 0 | 0 | 0 | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Net cash used in operating activities | |||||||||||||||||||
- | 0 | 0 | 0 | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Security deposits | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 0 | - | - | - | - | - | - | - | - |
Net cash used in operating activities | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | -35,000 | -37,801 | -38,143 | -31,428 | -30,469 | -20,669 | 0 | 0 | 0 |
Investing activities | |||||||||||||||||||
Purchases of property and equipment | |||||||||||||||||||
390 | 353 | 410 | 430 | 428 | 401 | 340 | 316 | 133 | 195 | 275 | 314 | 427 | 461 | 433 | 417 | 344 | 0 | 0 | 0 |
Maturities of short-term investments | |||||||||||||||||||
86,000 | 74,000 | 79,000 | 77,000 | 65,000 | 67,000 | 62,000 | 49,000 | 40,000 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Purchases of short-term investments | |||||||||||||||||||
- | 0 | 0 | 73,533 | - | 0 | 0 | 65,287 | - | 65,000 | 48,000 | 46,000 | 0 | 0 | 0 | 0 | - | - | - | - |
Net cash provided by investing activities | |||||||||||||||||||
- | 0 | 0 | 0 | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash provided by (used in) investing activities | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | -46,314 | -427 | -461 | -433 | -417 | -344 | 0 | 0 | 0 |
Financing activities | |||||||||||||||||||
Deferred offering costs | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - | - | 0 | 0 |
Proceeds from issuances of common stock under stock-based compensation plans | |||||||||||||||||||
228 | 388 | 674 | 654 | 714 | 701 | 440 | 430 | 144 | 219 | 388 | 359 | 436 | 0 | 0 | 0 | - | - | - | - |
Proceeds from exercise of stock options | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 |
Net cash provided by financing activities | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 75,846 | 75,795 | 75,706 | 142,856 | 66,100 | 65,980 | 0 | 0 | 0 |
Net cash provided by financing activities | |||||||||||||||||||
- | 0 | 0 | 0 | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Net (decrease) increase in cash and cash equivalents | |||||||||||||||||||
-513 | 34,166 | 32,119 | 38,254 | 33,440 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Supplemental cash flow information | |||||||||||||||||||
Net (decrease) increase in cash and cash equivalents | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | -50,056 | -78,467 | -5,468 | 37,567 | 37,102 | 110,995 | 35,214 | 44,967 | 0 | 0 | 0 |
Stock offering costs incurred, not yet paid | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - | - | 0 | 0 |