| Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 |
|---|---|---|---|---|---|---|
Revenues: | ||||||
Total revenues | ||||||
2,196 | 7,195 | 13,260 | - | - | - | - |
Collaborative revenue | ||||||
- | - | - | 4,157 | 1,052 | 0 | - |
Licensing revenue | ||||||
- | - | - | 3,500 | 4,500 | 729 | 876 |
Collaborative revenue | ||||||
- | - | - | - | - | - | 207 |
Product sales | ||||||
- | - | - | 1,853 | 881 | 870 | 1,877 |
Total revenues | ||||||
- | - | - | 9,510 | 6,433 | 1,599 | 2,960 |
Operating expenses: | ||||||
Cost of product sales | ||||||
1,435 | 84 | 481 | - | - | - | - |
Cost of product sales | ||||||
- | - | - | 774 | 638 | 669 | 1,518 |
Research and development | ||||||
42,415 | 43,670 | 45,134 | 33,087 | 22,746 | 11,554 | 8,604 |
General and administrative | ||||||
15,396 | 16,253 | 21,859 | 15,134 | 12,927 | 4,433 | 3,713 |
Total operating expenses | ||||||
59,246 | 60,007 | 67,474 | 48,995 | 36,311 | 16,656 | 13,835 |
Loss from operations | ||||||
-57,050 | -52,812 | -54,214 | -39,485 | -29,878 | -15,057 | -10,875 |
Interest and other income | ||||||
2,292 | 950 | 684 | 40 | 4 | 37 | 35 |
Change in fair value of convertible preferred stock warrant liability | ||||||
- | - | - | - | 4,277 | 955 | 0 |
Net loss | ||||||
-54,758 | -51,862 | -53,530 | -39,445 | -34,151 | -15,975 | -10,840 |
Unrealized gain (loss) on investments | ||||||
47 | -25 | -24 | 0 | 0 | - | - |
Comprehensive loss | ||||||
-54,711 | -51,887 | -53,554 | -39,445 | -34,151 | - | - |
Basic and diluted net loss per share (in dollars per share) | ||||||
-1.14 | -1.75 | -2.47 | -2.06 | -4.56 | -43.48 | -30.43 |
Weighted-average shares used to compute basic and diluted net loss per share (in shares) | ||||||
48,145 | 29,626 | 21,638 | 19,155 | 7,494 | 367 | 356 |
Collaborative revenue | ||||||
Total revenues | ||||||
1,533 | 6,880 | 4,633 | - | - | - | - |
Licensing revenue | ||||||
Total revenues | ||||||
0 | 0 | 7,000 | - | - | - | - |
Product sales | ||||||
Total revenues | ||||||
663 | 315 | 1,627 | - | - | - | - |