| Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 | Sep'13 | Jun'13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Revenues: | |||||||||||||||||||||
Total revenues | |||||||||||||||||||||
- | 462 | 755 | - | - | 516 | 729 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Collaborative revenue | |||||||||||||||||||||
- | - | - | 496 | - | - | - | 5,204 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Licensing revenue | |||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 7,000 | - | - | - | 3,500 | - | - | - | 3,500 | 1,000 | - | 13 | 514 |
Collaborative revenue | |||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 780 | 400 | 1,856 | - | 329 | 1,761 | 1,849 | - | 0 | 0 | 0 | - | 0 |
Product sales | |||||||||||||||||||||
- | - | - | 7 | - | - | - | 261 | - | 426 | 733 | 7 | 921 | 824 | 19 | 89 | 748 | 44 | 64 | 25 | 116 | 368 |
Total revenues | |||||||||||||||||||||
- | - | - | 503 | - | - | - | 5,465 | - | 8,206 | 1,133 | 1,863 | 1,139 | 4,653 | 1,780 | 1,938 | 1,800 | 3,544 | 1,064 | 25 | 129 | 882 |
Operating expenses: | |||||||||||||||||||||
Cost of product sales | |||||||||||||||||||||
- | 32 | - | - | - | 16 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Cost of product sales | |||||||||||||||||||||
- | - | 140 | 7 | - | - | 18 | 37 | - | 72 | 253 | 22 | 353 | 298 | 44 | 79 | 575 | 31 | 18 | 14 | 70 | 250 |
Research and development | |||||||||||||||||||||
9,836 | 11,268 | 11,000 | 10,311 | 8,523 | 10,246 | 10,863 | 14,038 | 12,005 | 11,173 | 11,386 | 10,570 | 8,878 | 8,263 | 8,483 | 7,463 | 8,797 | 5,988 | 3,883 | 4,078 | 2,920 | 3,356 |
General and administrative | |||||||||||||||||||||
3,593 | 3,802 | 4,006 | 3,995 | 4,321 | 3,909 | 3,888 | 4,135 | 4,443 | 9,554 | 3,948 | 3,914 | 4,048 | 3,506 | 3,778 | 3,802 | 5,549 | 4,082 | 1,850 | 1,446 | 1,132 | 914 |
Total operating expenses | |||||||||||||||||||||
14,685 | 15,102 | 15,146 | 14,313 | 12,857 | 14,171 | 14,769 | 18,210 | 16,582 | 20,799 | 15,587 | 14,506 | 13,279 | 12,067 | 12,305 | 11,344 | 14,921 | 10,101 | 5,751 | 5,538 | 4,122 | 4,520 |
Loss from operations | |||||||||||||||||||||
-14,209 | -14,640 | -14,391 | -13,810 | -12,372 | -13,655 | -14,040 | -12,745 | -14,524 | -12,593 | -14,454 | -12,643 | -12,140 | -7,414 | -10,525 | -9,406 | -13,121 | -6,557 | -4,687 | -5,513 | -3,993 | -3,638 |
Interest and other income | |||||||||||||||||||||
608 | 591 | 583 | 510 | 392 | 239 | 194 | 125 | 78 | 150 | 107 | 349 | 25 | 7 | 8 | 0 | 1 | 2 | 0 | 1 | -1 | 4 |
Change in fair value of convertible preferred stock warrant liability | |||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 127 | 1,439 | 2,711 | 0 | 0 |
Net loss | |||||||||||||||||||||
-13,601 | -14,049 | -13,808 | -13,300 | -11,980 | -13,416 | -13,846 | -12,620 | -14,446 | -12,443 | -14,347 | -12,294 | -12,115 | -7,407 | -10,517 | -9,406 | -13,120 | -6,682 | -6,126 | -8,223 | -3,994 | -3,634 |
Unrealized gain (loss) on investments | |||||||||||||||||||||
17 | 16 | 32 | -18 | -35 | 29 | 4 | -23 | -31 | -23 | 10 | 20 | 0 | 0 | 0 | 0 | - | - | - | - | - | - |
Comprehensive loss | |||||||||||||||||||||
-13,584 | -14,033 | -13,776 | -13,318 | -12,015 | -13,387 | -13,842 | -12,643 | -14,477 | -12,466 | -14,337 | -12,274 | -12,115 | -7,407 | -10,517 | -9,406 | - | - | - | - | - | - |
Basic and diluted net loss per share (in dollars per share) | |||||||||||||||||||||
-0.28 | -0.29 | -0.29 | -0.28 | -0.19 | -0.52 | -0.54 | -0.50 | -0.55 | -0.60 | -0.71 | -0.61 | -0.59 | -0.37 | -0.54 | -0.56 | 34.81 | -0.55 | -16.57 | -22.25 | -10.81 | -9.84 |
Weighted-average shares used to compute basic and diluted net loss per share (in shares) | |||||||||||||||||||||
48,168 | 48,164 | 48,125 | 48,122 | 41,856 | 25,620 | 25,567 | 25,463 | 25,441 | 20,803 | 20,155 | 20,153 | 20,191 | 20,131 | 19,356 | 16,944 | 17,110 | 12,128 | 369 | 369 | 369 | 369 |