| Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 | Sep'13 | Jun'13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Revenues: | |||||||||||||||||||||
Total revenues | |||||||||||||||||||||
- | 0 | 0 | - | - | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Collaborative revenue | |||||||||||||||||||||
- | - | - | 0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Licensing revenue | |||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 0 | - | - | - | 0 | - | - | - | 0 | 0 | - | 0 | 0 |
Collaborative revenue | |||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 0 | 0 | 0 | - | 0 | 0 | 0 | - | 0 | 0 | 0 | - | 0 |
Product sales | |||||||||||||||||||||
- | - | - | 61 | - | - | - | 1,881 | - | 2,087 | 2,485 | 1,771 | 1,853 | 1,680 | 900 | 945 | 881 | 249 | 573 | 0 | 0 | 0 |
Total revenues | |||||||||||||||||||||
- | - | - | 2,233 | - | - | - | 16,862 | - | 12,341 | 8,788 | 9,435 | 9,510 | 10,171 | 9,062 | 8,346 | 6,433 | 4,762 | 2,100 | 0 | 0 | 0 |
Operating expenses: | |||||||||||||||||||||
Cost of product sales | |||||||||||||||||||||
- | 0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Cost of product sales | |||||||||||||||||||||
- | - | 176 | 54 | - | - | 261 | 496 | - | 700 | 926 | 717 | 774 | 996 | 729 | 703 | 638 | 133 | 352 | 0 | 0 | 0 |
Research and development | |||||||||||||||||||||
42,415 | 41,102 | 40,080 | 39,943 | 43,670 | 47,152 | 48,079 | 48,602 | 45,134 | 42,007 | 39,097 | 36,194 | 33,087 | 33,006 | 30,731 | 26,131 | 22,746 | 16,869 | 14,237 | 0 | 0 | 0 |
General and administrative | |||||||||||||||||||||
15,396 | 16,124 | 16,231 | 16,113 | 16,253 | 16,375 | 22,020 | 22,080 | 21,859 | 21,464 | 15,416 | 15,246 | 15,134 | 16,635 | 17,211 | 15,283 | 12,927 | 8,510 | 5,342 | 0 | 0 | 0 |
Total operating expenses | |||||||||||||||||||||
59,246 | 57,418 | 56,487 | 56,110 | 60,007 | 63,732 | 70,360 | 71,178 | 67,474 | 64,171 | 55,439 | 52,157 | 48,995 | 50,637 | 48,671 | 42,117 | 36,311 | 25,512 | 19,931 | 0 | 0 | 0 |
Loss from operations | |||||||||||||||||||||
-57,050 | -55,213 | -54,228 | -53,877 | -52,812 | -54,964 | -53,902 | -54,316 | -54,214 | -51,830 | -46,651 | -42,722 | -39,485 | -40,466 | -39,609 | -33,771 | -29,878 | -20,750 | -17,831 | 0 | 0 | 0 |
Interest and other income | |||||||||||||||||||||
2,292 | 2,076 | 1,724 | 1,335 | 950 | 636 | 547 | 460 | 684 | 631 | 488 | 389 | 40 | 16 | 11 | 3 | 4 | 2 | 4 | 0 | 0 | 0 |
Change in fair value of convertible preferred stock warrant liability | |||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 4,277 | 4,277 | 4,150 | 0 | 0 | 0 |
Net loss | |||||||||||||||||||||
-54,758 | -53,137 | -52,504 | -52,542 | -51,862 | -54,328 | -53,355 | -53,856 | -53,530 | -51,199 | -46,163 | -42,333 | -39,445 | -40,450 | -39,725 | -35,334 | -34,151 | -25,025 | -21,977 | 0 | 0 | 0 |
Unrealized gain (loss) on investments | |||||||||||||||||||||
47 | -5 | 8 | -20 | -25 | -21 | -73 | -67 | -24 | 7 | 30 | 20 | 0 | 0 | 0 | 0 | - | - | - | - | - | - |
Comprehensive loss | |||||||||||||||||||||
-54,711 | -53,142 | -52,496 | -52,562 | -51,887 | -54,349 | -53,428 | -53,923 | -53,554 | -51,192 | -46,133 | -42,313 | -39,445 | 0 | 0 | 0 | - | - | - | - | - | - |
Basic and diluted net loss per share (in dollars per share) | |||||||||||||||||||||
-0.28 | -0.29 | -0.29 | -0.28 | -0.19 | -0.52 | -0.54 | -0.50 | -0.55 | -0.60 | -0.71 | -0.61 | -0.59 | -0.37 | -0.54 | -0.56 | 34.81 | -0.55 | -16.57 | -22.25 | -10.81 | -9.84 |
Weighted-average shares used to compute basic and diluted net loss per share (in shares) | |||||||||||||||||||||
48,168 | 48,164 | 48,125 | 48,122 | 41,856 | 25,620 | 25,567 | 25,463 | 25,441 | 20,803 | 20,155 | 20,153 | 20,191 | 20,131 | 19,356 | 16,944 | 17,110 | 12,128 | 369 | 369 | 369 | 369 |