| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenues: | ||||||||||
Total revenues | ||||||||||
2,158,759 | 1,881,883 | 1,536,216 | 1,105,719 | 753,751 | 511,495 | 354,947 | 297,059 | 94,455 | 169,878 | 9,265 |
Costs and expenses: | ||||||||||
Cost of product revenues (including definite-lived intangible amortization) | ||||||||||
114,249 | 94,123 | 79,479 | 58,187 | 26,972 | 3,004 | 630 | 157 | - | - | - |
Research and development | ||||||||||
1,154,111 | 1,197,957 | 1,326,134 | 581,861 | 479,514 | 347,523 | 260,436 | 210,391 | 178,707 | 123,880 | 119,442 |
Selling, general and administrative | ||||||||||
468,711 | 434,407 | 366,286 | 303,251 | 196,614 | 165,772 | 109,983 | 85,363 | 58,219 | 32,328 | 27,580 |
Change in fair value of acquisition-related contingent consideration | ||||||||||
19,682 | 26,173 | 7,704 | 17,422 | - | - | - | - | - | - | - |
Other expenses | ||||||||||
- | - | - | - | - | - | - | - | 712 | -379 | 2,011 |
Total costs and expenses | ||||||||||
1,756,753 | 1,752,660 | 1,779,603 | 960,721 | 703,100 | 516,299 | 371,049 | 295,911 | 237,638 | 155,829 | 149,033 |
Income (loss) from operations | ||||||||||
402,006 | 129,223 | -243,387 | 144,998 | 50,651 | -4,804 | -16,102 | 1,148 | -143,183 | 14,049 | -139,768 |
Other income (expense), net | ||||||||||
52,182 | 31,760 | 17,153 | 4,412 | 7,089 | 3,350 | 1,324 | 764 | 462 | 1,416 | 50 |
Interest expense | ||||||||||
1,855 | 1,543 | 6,900 | 38,745 | 45,603 | 46,828 | 38,652 | 46,058 | 43,819 | 43,323 | 32,125 |
Unrealized gain (loss) on long term investments | ||||||||||
34,458 | -44,093 | -24,275 | -3,261 | -4,581 | - | - | - | - | - | - |
Expense related to senior note conversions | ||||||||||
- | - | 54,881 | - | - | 265 | 11,484 | - | - | - | - |
Loss on repurchase of convertible senior notes | ||||||||||
- | - | - | - | - | - | -17,934 | - | - | -3,988 | -5,727 |
Loss on embedded derivative liability | ||||||||||
- | - | - | - | - | - | - | - | - | - | 34,300 |
Income (loss) before provision for income taxes | ||||||||||
486,791 | 115,347 | -312,290 | 107,404 | 7,556 | -48,547 | -82,848 | -44,146 | -186,540 | -31,846 | - |
Provision for income taxes | ||||||||||
39,885 | 5,854 | 852 | 3,182 | 1,025 | -66 | 299 | 174 | - | - | - |
Net (loss) income | ||||||||||
446,906 | 109,493 | -313,142 | 104,222 | 6,531 | -48,481 | -83,147 | -44,320 | -186,540 | -31,846 | -211,870 |
Basic and diluted net loss per share (in dollars per share) | ||||||||||
- | - | - | - | - | - | - | -0.34 | -1.49 | -0.26 | -2.06 |
Shares used in computing basic and diluted net loss per share (in shares) | ||||||||||
- | - | - | - | - | - | - | 129,747 | 125,362 | 121,628 | - |
Net income (loss) per share: | ||||||||||
Basic | ||||||||||
2.08 | 0.52 | -1.53 | 0.55 | 0.04 | -0.29 | -0.56 | - | - | - | - |
Diluted | ||||||||||
2.05 | 0.51 | -1.53 | 0.54 | 0.03 | -0.29 | -0.56 | - | - | - | - |
Shares used in computing net income (loss) per share: | ||||||||||
Basic | ||||||||||
214,913 | 212,383 | 204,580 | 187,873 | 179,601 | 167,947 | 148,403 | - | - | - | 102,943 |
Diluted | ||||||||||
217,657 | 215,635 | 204,580 | 194,125 | 187,302 | 167,947 | 148,403 | - | - | - | 102,943 |
Product revenues, net | ||||||||||
Total revenues | ||||||||||
1,774,922 | 1,466,900 | 1,200,312 | 882,404 | 601,015 | 357,562 | 235,443 | 136,001 | 2,012 | - | - |
Product royalty revenues | ||||||||||
Total revenues | ||||||||||
306,337 | 234,780 | 160,791 | 110,711 | 74,821 | 48,966 | 28,251 | 3,652 | - | - | 3,510 |
Other revenues | ||||||||||
Total revenues | ||||||||||
- | 203 | 113 | 92 | 58 | 110 | 206 | 458 | 495 | 930 | - |
Milestone revenues | ||||||||||
Total revenues | ||||||||||
77,500 | 180,000 | 175,000 | 112,512 | 77,857 | 104,857 | 91,047 | 156,948 | 91,948 | 168,948 | 5,755 |