| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
License fees | ||||||||||
- | - | - | - | - | - | - | - | 1,002 | 4 | 129 |
Other revenue | ||||||||||
- | - | - | - | - | - | 11,500 | - | - | - | - |
Grant revenue | ||||||||||
- | - | - | - | - | - | - | - | - | - | 1,044 |
Other expanded access program income, net | ||||||||||
- | - | - | - | - | - | - | - | 3,415 | 6,917 | 9,200 |
Revenues, net | ||||||||||
136,467 | 9,835 | 0 | 0 | 0 | - | 11,500 | - | 4,417 | 6,921 | 10,373 |
Cost of product revenues (excluding amortization of intangible assets) | ||||||||||
24,212 | 2,423 | 0 | 0 | - | - | - | - | - | - | - |
Gross profit | ||||||||||
112,255 | 7,412 | 0 | - | - | - | - | - | - | - | - |
Operating expenses: | ||||||||||
Research and development | ||||||||||
131,711 | 145,283 | 109,749 | 122,721 | 74,277 | 56,292 | 44,279 | 29,781 | 28,623 | 4,702 | 9,207 |
Selling, general and administrative | ||||||||||
210,796 | 168,218 | 79,171 | 50,679 | 43,216 | 31,073 | 22,236 | 12,657 | 11,523 | 10,311 | 9,840 |
Amortization of intangible assets | ||||||||||
4,993 | 1,249 | 0 | 0 | - | - | - | - | - | - | - |
Total costs and expenses | ||||||||||
347,500 | 314,750 | 188,920 | 173,400 | 117,493 | 87,365 | 66,515 | 42,438 | 66,136 | 15,013 | 19,047 |
Impairment loss | ||||||||||
- | - | - | - | - | - | - | - | 25,990 | 0 | 0 |
Operating loss | ||||||||||
-235,245 | -307,338 | -188,920 | -173,400 | -117,493 | -87,365 | -55,015 | -42,438 | -61,719 | -8,092 | -8,674 |
Investment income | ||||||||||
9,921 | 10,341 | 1,624 | 604 | 261 | 58 | 166 | 1,822 | 2,064 | 1,845 | 808 |
Interest expense | ||||||||||
27,705 | 25,472 | 5,925 | 3,498 | 2,889 | 2,415 | 2,412 | 763 | 10 | 109 | 781 |
Loss on extinguishment of debt | ||||||||||
0 | -2,209 | 0 | 0 | - | - | - | - | - | - | - |
Other income (expense), net | ||||||||||
-531 | 602 | 300 | 119 | -33 | 141 | -33 | 5 | 1 | - | - |
Loss before income taxes | ||||||||||
-253,560 | -324,076 | -192,921 | -176,175 | -120,154 | -89,581 | -57,294 | -41,374 | -59,664 | -6,356 | 118,827 |
Gain on sale of assets, net | ||||||||||
- | - | - | - | - | - | - | - | - | 0 | 127,474 |
Provision for income taxes | ||||||||||
777 | 201 | -272 | 98 | -1,971 | -10,422 | -1,221 | 0 | 0 | 78 | 477 |
Net loss | ||||||||||
-254,337 | -324,277 | -192,649 | -176,273 | -118,183 | -79,159 | -56,073 | -41,374 | -59,664 | -6,434 | 118,350 |
Basic and diluted net loss per share (in dollars per share) | ||||||||||
-3.01 | -4.22 | -2.89 | -2.85 | -2.02 | -1.84 | -1.60 | -1.56 | -2.95 | -0.49 | - |
Weighted average basic and diluted common shares outstanding | ||||||||||
84,560 | 76,889 | 66,576 | 61,892 | 58,633 | 43,095 | 34,980 | 26,545 | 23,348 | 13 | 12 |
Accretion of beneficial conversion charge | ||||||||||
- | - | - | - | - | - | - | - | -9,175 | 0 | 0 |
Net loss | ||||||||||
-254,337 | -324,277 | -192,649 | -176,273 | -118,183 | -79,159 | - | -41,374 | -68,839 | -6,434 | 118,350 |
Other comprehensive income (loss): | ||||||||||
Foreign currency translation (losses) gains | ||||||||||
-1 | -6 | 62 | -65 | 0 | - | - | - | - | - | - |
Net loss attributable to common stockholders | ||||||||||
-254,337 | -324,277 | -192,649 | -176,273 | -118,183 | - | - | - | -68,839 | -6,434 | 118,350 |
Unrealized loss on investments, net of taxes | ||||||||||
- | - | - | - | - | - | - | -450 | -543 | 993 | - |
Total comprehensive loss | ||||||||||
-254,338 | -324,283 | -192,587 | -176,338 | -118,183 | -79,159 | - | -41,824 | -69,382 | -5,441 | - |
Diluted net (loss) income attributable to common stockholders per common share (in dollars per share) | ||||||||||
- | - | - | - | - | - | - | - | - | - | 9.30 |
Weighted average diluted common shares outstanding (in shares) | ||||||||||
- | - | - | - | - | - | - | - | - | 13,250 | 12 |
Basic net (loss) income attributable to common stockholders per common share (in dollars per share) | ||||||||||
- | - | - | - | - | - | - | - | - | - | 9.31 |