| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | ||
|---|---|---|---|---|---|---|
Operating activities: | ||||||
Net loss | ||||||
56,823 | -27,379 | -16,443 | -13,703 | -28,532 | ||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Stock-based compensation expense | ||||||
9,609 | 9,407 | 4,775 | 4,989 | 1,352 | ||
Depreciation expense | ||||||
3,900 | 3,800 | 4,400 | 1,944 | 1,470 | ||
Change in other financing income, net | ||||||
- | - | - | 0 | 1,859 | ||
Net amortization of premiums and discounts on investments | ||||||
1,480 | 1,107 | -1,172 | -327 | 0 | ||
Loss on disposal of property and equipment | ||||||
- | - | -75 | 0 | 0 | ||
Changes in operating assets and liabilities: | ||||||
Taxes receivable | ||||||
0 | -16,737 | 0 | - | - | ||
Prepaid expenses and other current assets | ||||||
1,375 | -873 | 17,416 | 1,979 | 23 | ||
Other non-current assets | ||||||
728 | 0 | 266 | 527 | 99 | ||
Accounts payable | ||||||
-944 | 562 | 373 | -312 | 673 | ||
Accrued expenses and other current liabilities | ||||||
1,983 | -1,443 | 4,120 | 953 | 1,929 | ||
Deferred revenue—related party | ||||||
-97,872 | -65,201 | -71,644 | - | - | ||
Other liabilities | ||||||
4 | 107 | - | - | - | ||
Deferred revenuerelated party | ||||||
- | - | - | 187,804 | 0 | ||
Other non-current liabilities | ||||||
- | - | - | 0 | -28 | ||
Deferred rent | ||||||
- | - | -156 | 192 | -622 | ||
Net cash used in operating activities | ||||||
-30,129 | -63,613 | -90,988 | 179,688 | -25,739 | ||
Investing activities: | ||||||
Purchases of investments | ||||||
188,999 | 252,918 | 179,874 | 213,286 | 0 | ||
Proceeds from maturities of investments | ||||||
221,366 | 336,694 | 141,322 | 0 | 0 | ||
Proceeds from sales of investments | ||||||
0 | 3,997 | 15,638 | - | - | ||
Proceeds from sales of investments | ||||||
- | - | - | 0 | 0 | ||
Purchases of property and equipment | ||||||
985 | 1,359 | 15,107 | 2,222 | 2,202 | ||
Change in restricted cash | ||||||
- | - | - | 0 | -60 | ||
Net cash provided by investing activities | ||||||
31,382 | 86,414 | -38,021 | -215,508 | -2,142 | ||
Financing activities: | ||||||
Proceeds from at the market offering, net of issuance costs | ||||||
3,645 | 0 | - | - | - | ||
Proceeds from initial public offering of common stock, net of issuance costs | ||||||
- | - | 107,008 | 0 | 0 | ||
Proceeds from exercise of stock options | ||||||
- | - | 462 | 50 | 112 | ||
Proceeds from exercise of stock options | ||||||
437 | 1,546 | - | - | - | ||
Cash paid for issuance costs | ||||||
- | - | - | 620 | 241 | ||
Net cash provided by financing activities | ||||||
4,082 | 1,546 | 107,470 | 35,507 | 70,704 | ||
Net increase (decrease) in cash, cash equivalents and restricted cash | ||||||
5,335 | 24,347 | -21,539 | - | - | ||
Non-cash investing and financing activities: | ||||||
Net (decrease) increase in cash and cash equivalents | ||||||
- | - | - | -313 | 42,823 | ||
Non-cash investing and financing activities: | ||||||
Accretion of convertible preferred stock to redemption value | ||||||
- | - | - | 0 | 1,011 | ||
Reclassification of tranche rights upon issuance of preferred stock | ||||||
- | - | - | 0 | 1,725 | ||
Purchases of property and equipment in accounts payable and accrued expenses | ||||||
29 | 31 | 170 | 1,870 | 22 | ||
Issuance costs in accounts payable and accrued expenses | ||||||
134 | 0 | - | 850 | 1,580 | ||
Supplemental cash flow information: | ||||||
Cash paid for lease liabilities | ||||||
4,270 | 0 | - | - | - | ||
Cash paid for income taxes | ||||||
101 | 0 | 16,750 | 0 | 0 | ||