| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities: | ||||||||||||||||
Net loss | ||||||||||||||||
-26,443 | -22,667 | 98,860 | -6,993 | -12,377 | -2,040 | -7,637 | -4,674 | -13,028 | -9,364 | -4,084 | -3,380 | 385 | 5,466 | 4,070 | -12,349 | -10,890 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||
Stock-based compensation expense | ||||||||||||||||
2,618 | 2,265 | 2,289 | 2,513 | 2,542 | 2,444 | 2,335 | 2,360 | 2,268 | 1,312 | 1,074 | 1,036 | 1,353 | 1,269 | 2,625 | 655 | 440 |
Depreciation expense | ||||||||||||||||
938 | 994 | 983 | 963 | 960 | 933 | 959 | 961 | 947 | 900 | 909 | 1,625 | 966 | 545 | 487 | 465 | 447 |
Net amortization of premiums and discounts on investments | ||||||||||||||||
84 | 233 | 364 | 409 | 474 | 498 | 471 | 307 | -169 | -306 | -309 | -278 | -279 | -237 | -90 | 0 | 0 |
Other non-cash items | ||||||||||||||||
-19 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Loss on disposal of property and equipment | ||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | 14 | - | - | - | 0 |
Changes in operating assets and liabilities: | ||||||||||||||||
Prepaid expenses and other current assets | ||||||||||||||||
543 | -399 | -75 | -747 | 2,596 | -271 | -13 | -1,076 | 487 | 11,475 | 5,104 | -800 | 1,637 | - | - | - | - |
Prepaid expenses and other current assets | ||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 474 |
Other non-current assets | ||||||||||||||||
-18 | 146 | -46 | 525 | 103 | 50 | -19 | 14 | -45 | -39 | 218 | -52 | 139 | 1,339 | 290 | -1,094 | -8 |
Accounts payable | ||||||||||||||||
1,407 | -1,111 | 812 | -1,416 | 771 | 331 | 30 | -2,088 | 2,289 | -934 | 984 | -820 | 1,143 | 623 | -235 | -898 | 198 |
Accrued expenses and other current liabilities | ||||||||||||||||
-1,457 | 1,953 | -305 | 1,276 | -941 | -782 | 760 | 747 | -2,168 | 2,049 | 285 | 2,098 | -312 | 1,316 | 482 | 174 | -1,019 |
Deferred revenue—related party | ||||||||||||||||
0 | 0 | -69,445 | -17,446 | -10,981 | -20,100 | -14,528 | -19,378 | -11,195 | - | - | - | - | - | - | - | - |
Other liabilities | ||||||||||||||||
-19 | -4 | -5 | -3 | 16 | 22 | 22 | 22 | 41 | - | - | - | - | - | - | - | - |
Deferred revenuerelated party | ||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | -20,290 | -20,288 | 208,092 | 0 | 0 |
Deferred rent | ||||||||||||||||
- | - | - | - | - | - | - | - | - | 51 | 50 | -1,084 | 827 | 687 | -165 | -162 | -168 |
Net cash used in operating activities | ||||||||||||||||
-23,546 | -18,599 | 32,946 | -21,293 | -23,183 | -19,438 | -18,498 | -4,558 | -21,119 | -24,171 | -24,812 | -24,566 | -17,439 | -11,873 | 214,837 | -11,818 | -11,458 |
Investing activities: | ||||||||||||||||
Purchases of investments | ||||||||||||||||
19,856 | 41,004 | 58,515 | 27,461 | 62,019 | 58,219 | 66,810 | 126,887 | 1,002 | 34,988 | 11,623 | 25,541 | 107,722 | 31,012 | 182,274 | 0 | 0 |
Proceeds from maturities of investments | ||||||||||||||||
63,650 | 42,705 | 54,153 | 47,000 | 77,508 | 72,267 | 88,514 | 55,100 | 120,813 | 55,087 | 23,167 | 29,518 | 33,550 | - | - | - | - |
Proceeds from sales of investments | ||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | 8,396 | - | - | - | - |
Sales and maturities of investments | ||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 |
Purchases of property and equipment | ||||||||||||||||
50 | 0 | 423 | 453 | 109 | 234 | 166 | 729 | 230 | 1,414 | 1,731 | 4,885 | 7,077 | 968 | 620 | 384 | 250 |
Net cash provided by investing activities | ||||||||||||||||
43,744 | 1,701 | -4,785 | 19,086 | 15,380 | 13,814 | 21,538 | -68,519 | 119,581 | 18,685 | 9,813 | 6,334 | -72,853 | -31,980 | -182,894 | -384 | -250 |
Financing activities: | ||||||||||||||||
Proceeds from at the market offering, net of issuance costs | ||||||||||||||||
1,514 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Proceeds from initial public offering of common stock, net of issuance costs | ||||||||||||||||
- | - | - | - | - | - | - | - | - | 0 | 0 | -318 | 107,326 | 0 | 0 | 0 | 0 |
Proceeds from exercise of stock options | ||||||||||||||||
38 | 92 | 247 | 29 | 69 | 247 | 134 | 381 | 784 | - | 151 | 41 | 109 | - | 4 | 24 | 18 |
Cash paid for issuance costs | ||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -1,640 | 1,643 |
Net cash provided by financing activities | ||||||||||||||||
1,552 | 3,737 | 247 | 29 | 69 | 247 | 134 | 381 | 784 | 161 | 151 | -277 | 107,435 | -616 | 36,084 | 1,664 | -1,625 |
Net increase (decrease) in cash, cash equivalents and restricted cash | ||||||||||||||||
21,750 | -13,161 | 28,408 | -2,178 | -7,734 | -5,377 | 3,174 | -72,696 | 99,246 | -5,325 | -14,848 | -18,509 | 17,143 | - | - | - | - |
Non-cash investing and financing activities: | ||||||||||||||||
Net (decrease) increase in cash and cash equivalents | ||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | -44,469 | 68,027 | -10,538 | -13,333 |
Non-cash investing and financing activities: | ||||||||||||||||
Purchases of property and equipment in accounts payable and accrued expenses | ||||||||||||||||
0 | - | - | -20 | 20 | - | - | -468 | 578 | -596 | -1 | -1,596 | 2,363 | 1,666 | 30 | 15 | 159 |
Issuance costs in accounts payable and accrued expenses | ||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | 232 | 730 | 93 | -81 | 108 |
Supplemental cash flow information: | ||||||||||||||||
Cash paid for lease liabilities | ||||||||||||||||
1,090 | 1,070 | 1,070 | 1,070 | 1,060 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |