| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net loss | ||||||
-24,522 | -56,466 | -43,386 | -16,516 | -54,664 | -24,455 | -5,226 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Gain on extinguishment of debt | ||||||
- | 2 | - | -4,740 | 0 | 1,900 | - |
Write-off of deferred offering costs | ||||||
116 | - | 60 | 445 | 0 | - | - |
Stock-based compensation expense | ||||||
4,410 | 6,495 | 4,562 | 6,600 | 2,369 | 214 | 134 |
Non-cash interest expense | ||||||
1,417 | 2,089 | - | - | - | - | - |
Non-cash interest expense | ||||||
- | - | 2,222 | 2,222 | 2,671 | 1,602 | 152 |
Amortization of debt issuance costs and debt discount | ||||||
1,656 | 1,618 | 1,561 | 1,616 | 1,909 | 1,114 | 1,560 |
Depreciation and amortization expense | ||||||
304 | 324 | 336 | 175 | 84 | 75 | 68 |
Fair value adjustment related to derivative and warrant liability | ||||||
-1,998 | -5,976 | 3,091 | -32,465 | 27,276 | 7,223 | -1,137 |
Change in estimated deferred offering costs | ||||||
116 | - | 60 | 445 | 0 | 0 | - |
Loss on sublease and disposal of fixed assets | ||||||
- | - | -104 | -91 | 0 | - | - |
Loss on disposal of fixed assets | ||||||
- | - | - | - | - | 0 | - |
Change in assets and liabilities: | ||||||
Accounts and other receivables | ||||||
1,725 | - | - | - | - | - | - |
Prepaid expenses and other assets | ||||||
-544 | 548 | 926 | -2,018 | 1,228 | -523 | 4 |
Operating lease right-of-use assets | ||||||
1,537 | - | - | - | - | - | - |
Accounts payable and accrued expenses | ||||||
-3,789 | -1,635 | -801 | 1,118 | 1,315 | 933 | 126 |
Operating lease liabilities | ||||||
2,185 | - | - | - | - | - | - |
Other liabilities | ||||||
-798 | -102 | 77 | 184 | 0 | 0 | - |
Net cash used in operating activities | ||||||
-23,737 | -54,203 | -33,100 | -29,772 | -20,268 | - | - |
Cash flows from investing activities: | ||||||
Net cash used in operating activities | ||||||
- | - | - | - | - | -14,671 | -4,327 |
Proceeds from sale of assets | ||||||
- | - | - | - | - | - | 17 |
Purchases of property and equipment | ||||||
26 | 21 | 181 | 643 | 135 | 47 | 51 |
Restricted cash for collateral | ||||||
- | - | - | - | - | 0 | - |
Purchases of marketable securities and long-term investments | ||||||
- | - | 27,378 | 89,849 | 19,002 | 0 | - |
Maturities of marketable securities | ||||||
3,260 | 33,353 | 54,971 | 44,645 | 0 | 0 | - |
Net cash (used in) provided by investing activities | ||||||
3,234 | 33,332 | 27,412 | -45,847 | -19,137 | - | - |
Cash flows from financing activities: | ||||||
Proceeds from equity line of credit | ||||||
5,446 | - | - | - | - | - | - |
Proceeds from at-the-market offering, net of commissions | ||||||
- | 4,828 | - | - | - | - | - |
Proceeds from underwritten public offering, net of commissions | ||||||
- | 23,500 | - | - | - | - | - |
Repayment of obligations under capital lease | ||||||
- | 193 | 157 | 79 | 32 | 31 | 53 |
Payment of debt and stock issuance costs | ||||||
- | - | - | 983 | 2,533 | 163 | - |
Payment of deferred offering costs | ||||||
- | 184 | - | - | - | - | - |
Repayment of principal on finance lease liabilities | ||||||
207 | - | - | - | - | - | - |
Payment of debt issuance costs | ||||||
300 | - | - | - | - | - | - |
Proceeds from exercise of common stock options | ||||||
- | 68 | - | - | - | - | - |
Net cash provided by (used in) investing activities | ||||||
- | - | - | - | - | -47 | -34 |
Proceeds from issuance of debt, net of discounts and commissions | ||||||
- | - | - | 82,800 | 0 | 25,000 | 3,846 |
Repayment of term notes and related accrued interest | ||||||
- | - | - | 18,621 | 0 | 0 | - |
Payment of principal on convertible notes arising from capitalized interest | ||||||
- | - | - | 1,931 | 0 | 0 | - |
Payment of deferred offering costs | ||||||
- | - | 50 | 164 | 315 | 1,767 | - |
Proceeds from exercise of common stock options | ||||||
- | - | 4 | 141 | 413 | 0 | - |
Proceeds from initial public offering, net of discounts and commissions | ||||||
- | - | - | 0 | 59,892 | 0 | - |
Net cash provided by financing activities | ||||||
4,939 | 28,019 | -203 | 61,163 | 61,468 | - | - |
Net decrease in cash, cash equivalents and restricted cash | ||||||
-15,564 | 7,148 | -5,891 | -14,456 | 22,063 | - | - |
Repayment of line of credit | ||||||
- | - | - | - | - | 35 | 5 |
Net cash (used in) provided by financing activities | ||||||
- | - | - | - | - | 23,004 | 3,788 |
Net decrease in cash and cash equivalents | ||||||
- | - | - | - | - | 8,286 | -573 |
Supplemental cash flow information: | ||||||
Cash paid for interest | ||||||
5,362 | 5,539 | 5,717 | 3,289 | 0 | - | - |
Deferred offering costs included in accounts payable and accrued expenses | ||||||
- | 181 | - | 85 | 428 | 315 | - |
Trade date receivables | ||||||
- | - | 2,005 | 5,003 | 0 | 0 | - |
Conversion of preferred stock into common stock upon initial public offering | ||||||
- | - | - | 0 | 28,207 | 0 | - |
Unpaid offering costs charged to equity | ||||||
- | - | - | 0 | 3,276 | 0 | - |
Reclassification of 2013 warrants to equity | ||||||
- | - | - | 0 | 1,110 | 0 | - |
Embedded put option on Deerfield warrant | ||||||
- | - | - | - | - | 220 | - |
Issuance of Series D preferred stock as transaction fee | ||||||
- | - | - | - | - | 1,500 | - |
Deerfield Convertible Note principal and interest converted to common stock | ||||||
- | - | - | - | - | 4,159 | - |
Commitment shares issued in connection with equity line of credit included in deferred offering costs | ||||||
300 | - | - | - | - | - | - |
Property and equipment financed under a lease agreement | ||||||
- | 52 | - | - | - | - | - |
Property and equipment financed under a lease agreement | ||||||
- | - | 284 | 867 | 0 | 0 | 94 |
Cash paid for interest | ||||||
- | - | - | - | - | 3 | 5 |
Transfer of warrants to equity upon exercise | ||||||
- | - | - | 755 | 4,293 | 0 | - |
Property and equipment included in accounts payable and accrued expenses | ||||||
4 | - | 3 | 281 | 0 | 0 | - |
Conversion feature on 2013 convertible notes and put option | ||||||
- | - | - | - | - | - | 1,150 |
Issuance of 2013 warrants and Deerfield warrant | ||||||
- | - | - | - | - | 7,610 | 410 |
Conversion from Deerfield Convertible Note to Common Stock [Member] | ||||||
Deerfield Convertible Note principal and interest converted to common stock | ||||||
- | 3,502 | - | - | - | - | - |
The 2021 Notes Converted to Preferred Stock [Member] | ||||||
2021 Notes principal converted to preferred stock | ||||||
1,537 | 9,577 | - | - | - | - | - |
The 2021 Notes Converted to Common Stock [Member] | ||||||
2019 Notes principal converted to common stock | ||||||
1,463 | - | - | - | - | - | - |
The 2019 Notes Converted to Common Stock [Member] | ||||||
2021 Notes principal converted to preferred stock | ||||||
1,200 | - | - | - | - | - | - |