| Dec'19 | Dec'18 | Dec'17 | ||||
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net loss | ||||||
-161,867 | -103,227 | -64,873 | ||||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation expense | ||||||
2,068 | 286 | 28 | ||||
Share-based compensation expense | ||||||
15,080 | 5,701 | 897 | ||||
Class A common shares issued or to be issued as consideration for Primatope, including milestone payments | ||||||
8,800 | - | - | ||||
Loss on disposal of property and equipment | ||||||
-21 | -66 | - | ||||
Other | ||||||
- | 235 | - | ||||
Non-cash lease expense | ||||||
1,211 | - | - | ||||
Accretion of discounts on short-term investments | ||||||
3,501 | 1,423 | - | ||||
Deferred income taxes | ||||||
-3,156 | -978 | -197 | ||||
Changes in operating assets and liabilities: | ||||||
Prepaid expenses, right-of-use assets and other assets | ||||||
1,020 | 4,791 | 1,185 | ||||
Accounts payable | ||||||
-4,705 | 8,823 | 1,006 | ||||
Accrued expenses and other liabilities | ||||||
4,638 | 9,296 | 4,105 | ||||
Accrued milestones | ||||||
-15,000 | 5,000 | 10,000 | ||||
Operating lease liabilities | ||||||
-1,264 | - | - | ||||
Other long-term liabilities | ||||||
326 | - | - | ||||
Net cash used in operating activities | ||||||
-158,369 | -81,012 | -50,219 | ||||
Cash flows from investing activities: | ||||||
Purchases of property and equipment | ||||||
3,203 | 5,290 | 69 | ||||
Purchases of short-term investments | ||||||
488,773 | 402,008 | - | ||||
Proceeds from the maturities of short-term investments | ||||||
541,190 | 168,100 | - | ||||
Net cash provided by (used in) investing activities | ||||||
49,214 | -239,198 | -69 | ||||
Cash flows from financing activities: | ||||||
Payments of offering costs | ||||||
118 | 3,657 | - | ||||
Proceeds from exercise of options and employee share purchase plan | ||||||
1,119 | 377 | - | ||||
Net cash provided by financing activities | ||||||
84,107 | 346,736 | 39,873 | ||||
Net increase in cash, cash equivalents and restricted cash | ||||||
-25,048 | 26,526 | -10,415 | ||||
Supplemental information: | ||||||
Cash paid for income taxes | ||||||
1,724 | 383 | 290 | ||||
Supplemental disclosure of non-cash investing and financing activities: | ||||||
Deferred offering costs included in accrued expenses and accounts payable | ||||||
- | 404 | 25 | ||||
Property and equipment included in accrued expenses and accounts payable | ||||||
222 | 1,292 | - | ||||
Series B convertible preferred shares | ||||||
Proceeds from issuance of convertible preferred shares, net of issuance costs | ||||||
- | - | 39,873 | ||||
Series C convertible preferred shares | ||||||
Proceeds from issuance of convertible preferred shares, net of issuance costs | ||||||
- | 190,822 | - | ||||