| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 |
|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||||
Net loss | ||||||||
-26,419 | -31,797 | -27,058 | -37,191 | -65,821 | -42,580 | -24,406 | -20,259 | -15,982 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||
Depreciation expense | ||||||||
594 | 566 | 523 | 508 | 471 | 254 | 12 | 12 | 8 |
Share-based compensation expense | ||||||||
4,209 | 4,965 | 3,758 | 3,464 | 2,893 | 2,582 | 1,502 | 1,059 | 558 |
Class A common shares issued or to be issued as consideration for Primatope, including milestone payments | ||||||||
- | 0 | 0 | 1,800 | 7,000 | - | - | - | - |
Loss on disposal of property and equipment | ||||||||
- | - | - | - | - | 0 | 0 | 0 | -66 |
Non-cash lease expense | ||||||||
300 | - | - | - | 334 | - | - | - | - |
Non-cash rent expense | ||||||||
- | - | - | - | - | - | 50 | 178 | 30 |
Accretion of discounts on short-term investments | ||||||||
228 | 457 | 989 | 1,209 | 846 | - | - | - | - |
Deferred income taxes | ||||||||
-1,038 | 255 | -2,021 | -1,150 | -240 | -43 | -472 | -323 | -140 |
Changes in operating assets and liabilities: | ||||||||
Prepaid expenses, right-of-use assets and other assets | ||||||||
598 | -452 | 463 | -535 | 1,544 | 764 | 1,062 | 3,169 | -204 |
Accounts payable | ||||||||
-1,197 | -201 | -2,841 | 1,680 | -3,343 | 5,842 | 3,728 | -1,838 | 1,091 |
Accrued expenses and other liabilities | ||||||||
-7,061 | 1,953 | -35 | 3,096 | -376 | 2,847 | 833 | 6,423 | -807 |
Accrued milestones | ||||||||
- | -150 | 150 | -13,000 | -2,000 | - | - | - | - |
Operating lease liabilities | ||||||||
-413 | -348 | -314 | -309 | -293 | - | - | - | - |
Other long-term liabilities | ||||||||
55 | -617 | 0 | 434 | 509 | - | - | - | - |
Net cash used in operating activities | ||||||||
-31,796 | -24,170 | -29,267 | -41,676 | -63,256 | -27,638 | -20,485 | -17,917 | -14,972 |
Cash flows from investing activities: | ||||||||
Purchases of property and equipment | ||||||||
223 | 1,996 | 440 | -794 | 1,561 | 4,016 | 963 | 236 | 75 |
Purchases of short-term investments | ||||||||
26,187 | 82,638 | 132,647 | 91,681 | 181,807 | - | - | - | - |
Proceeds from the maturities of short-term investments | ||||||||
115,200 | 86,550 | 148,300 | 132,250 | 174,090 | - | - | - | - |
Net cash provided by (used in) investing activities | ||||||||
88,790 | 1,916 | 15,213 | 41,363 | -9,278 | 29,660 | -194,871 | -73,912 | -75 |
Cash flows from financing activities: | ||||||||
Payments of offering costs | ||||||||
- | 0 | 0 | 18 | 100 | 11 | 821 | 2,796 | 29 |
Proceeds from exercise of options and employee share purchase plan | ||||||||
2,414 | 373 | 53 | 512 | 181 | 301 | 59 | 0 | 17 |
Net cash provided by financing activities | ||||||||
2,414 | 373 | 53 | 494 | 83,187 | 291 | -762 | 156,397 | 190,810 |
Net increase in cash, cash equivalents and restricted cash | ||||||||
59,408 | -21,881 | -14,001 | 181 | 10,653 | 2,313 | -216,118 | 64,568 | 175,763 |
Supplemental disclosure of non-cash investing and financing activities: | ||||||||
Deferred offering costs included in accrued expenses and accounts payable | ||||||||
- | - | - | - | 19 | 393 | -845 | -723 | 1,579 |
Property and equipment included in accrued expenses and accounts payable | ||||||||
- | -149 | 118 | 216 | 37 | - | - | - | - |
Series C convertible preferred shares | ||||||||
Proceeds from issuance of convertible preferred shares, net of issuance costs | ||||||||
- | - | - | - | - | 0 | 0 | 0 | 190,822 |