| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 |
|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||||
Net loss | ||||||||
-122,465 | -161,867 | -172,650 | -169,998 | -153,066 | -103,227 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||
Depreciation expense | ||||||||
2,191 | 2,068 | 1,756 | 1,245 | 749 | 286 | 0 | 0 | 0 |
Share-based compensation expense | ||||||||
16,396 | 15,080 | 12,697 | 10,441 | 8,036 | 5,701 | 0 | 0 | 0 |
Class A common shares issued or to be issued as consideration for Primatope, including milestone payments | ||||||||
- | 8,800 | 0 | 0 | 0 | - | - | - | - |
Loss on disposal of property and equipment | ||||||||
- | - | - | - | - | -66 | 0 | 0 | 0 |
Non-cash lease expense | ||||||||
0 | - | - | - | 0 | - | - | - | - |
Non-cash rent expense | ||||||||
- | - | - | - | - | - | 0 | 0 | 0 |
Accretion of discounts on short-term investments | ||||||||
2,883 | 3,501 | 0 | 0 | 0 | - | - | - | - |
Deferred income taxes | ||||||||
-3,954 | -3,156 | -3,454 | -1,905 | -1,078 | -978 | 0 | 0 | 0 |
Changes in operating assets and liabilities: | ||||||||
Prepaid expenses, right-of-use assets and other assets | ||||||||
74 | 1,020 | 2,236 | 2,835 | 6,539 | 4,791 | 0 | 0 | 0 |
Accounts payable | ||||||||
-2,559 | -4,705 | 1,338 | 7,907 | 4,389 | 8,823 | 0 | 0 | 0 |
Accrued expenses and other liabilities | ||||||||
-2,047 | 4,638 | 5,532 | 6,400 | 9,727 | 9,296 | 0 | 0 | 0 |
Accrued milestones | ||||||||
- | -15,000 | 0 | 0 | 0 | - | - | - | - |
Operating lease liabilities | ||||||||
-1,384 | -1,264 | 0 | 0 | 0 | - | - | - | - |
Other long-term liabilities | ||||||||
-128 | 326 | 0 | 0 | 0 | - | - | - | - |
Net cash used in operating activities | ||||||||
-126,909 | -158,369 | -161,837 | -153,055 | -129,296 | -81,012 | 0 | 0 | 0 |
Cash flows from investing activities: | ||||||||
Purchases of property and equipment | ||||||||
1,865 | 3,203 | 5,223 | 5,746 | 6,776 | 5,290 | 0 | 0 | 0 |
Purchases of short-term investments | ||||||||
333,153 | 488,773 | 0 | 0 | 0 | - | - | - | - |
Proceeds from the maturities of short-term investments | ||||||||
482,300 | 541,190 | 0 | 0 | 0 | - | - | - | - |
Net cash provided by (used in) investing activities | ||||||||
147,282 | 49,214 | 76,958 | -133,126 | -248,401 | -239,198 | 0 | 0 | 0 |
Cash flows from financing activities: | ||||||||
Payments of offering costs | ||||||||
- | 118 | 129 | 950 | 3,728 | 3,657 | 0 | 0 | 0 |
Proceeds from exercise of options and employee share purchase plan | ||||||||
3,352 | 1,119 | 1,047 | 1,053 | 541 | 377 | 0 | 0 | 0 |
Net cash provided by financing activities | ||||||||
3,334 | 84,107 | 84,025 | 83,210 | 239,113 | 346,736 | 0 | 0 | 0 |
Net increase in cash, cash equivalents and restricted cash | ||||||||
23,707 | -25,048 | -854 | -202,971 | -138,584 | 26,526 | 0 | 0 | 0 |
Supplemental disclosure of non-cash investing and financing activities: | ||||||||
Deferred offering costs included in accrued expenses and accounts payable | ||||||||
- | - | - | - | -1,156 | 404 | 0 | 0 | 0 |
Property and equipment included in accrued expenses and accounts payable | ||||||||
- | 222 | 0 | 0 | 0 | - | - | - | - |
Series C convertible preferred shares | ||||||||
Proceeds from issuance of convertible preferred shares, net of issuance costs | ||||||||
- | - | - | - | - | 190,822 | 0 | 0 | 0 |