Karyopharm therapeutics inc. (KPTI)
CashFlow / Quarterly
Mar'20Dec'19Sep'19Jun'19Mar'19Dec'18Sep'18Jun'18Mar'18Dec'17Sep'17Jun'17Mar'17Dec'16Sep'16Jun'16Mar'16Dec'15Sep'15Jun'15Mar'15Dec'14Sep'14Jun'14Mar'14
Operating activities
Net loss

-52,931

-48,647

-41,367

-43,415

-66,161

-58,210

-48,083

-33,655

-38,459

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Net loss

-

-

-

-

-

-

-

-

-

-

-

-

-29,917

-

-25,425

-30,158

-27,059

-29,046

-30,373

-32,695

-26,067

-25,928

-19,724

-16,431

-13,694

Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization

242

270

243

242

245

159

188

184

169

161

176

180

183

180

179

179

179

177

165

156

136

132

106

42

43

Net amortization of premiums and discounts on investments

-12

140

274

446

522

251

-10

-110

-160

-284

-311

-325

-267

-360

-244

-281

-314

-435

-527

-585

-231

-

-

-

-

Amortization of debt discount and issuance costs

1,912

1,895

1,805

1,789

1,704

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Stock-based compensation expense

5,152

3,549

3,719

4,116

3,907

3,897

4,774

4,440

4,164

4,499

4,868

5,129

5,909

5,126

5,594

6,405

5,158

5,344

3,482

4,482

3,749

4,591

2,915

3,888

2,846

Changes in operating assets and liabilities:
Accounts receivable

1,419

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Inventory

624

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Prepaid expenses and other current assets

268

1,976

-366

-1,339

597

1,624

1,354

1,047

638

-324

1

-80

61

532

91

-260

-243

-1,025

-958

1,151

887

-2,188

1,239

303

691

Operating lease right-of-use assets

-297

-287

-276

-268

-263

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Other assets

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-175

0

-322

967

Accounts payable

711

-2,086

1,956

-1,155

-2,016

2,045

-1,555

-1,097

-773

3,776

-1,360

-985

-522

2,604

-1,892

-61

294

-327

-317

-2,050

268

4,134

-1,323

152

1,533

Accrued expenses and other liabilities

3,350

7,943

5,149

-1,325

-3,255

3,116

6,515

1,329

295

3,647

4,939

1,982

-498

-733

1,031

2,352

-2,282

2,164

156

1,745

1,701

1,844

1,972

246

383

Deferred revenue

-1,054

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Operating lease liabilities

-391

-378

-351

-255

-191

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Deferred revenue

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-14

-22

-21

-22

Deferred rent

-

-

-

-

-

-1,241

-841

-134

-430

73

68

70

69

-

-

63

12

558

-72

-55

-644

-

-

-

-

Net cash used in operating activities

-45,011

-39,489

-36,506

-48,204

-66,623

-48,172

-38,665

-37,628

-34,652

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Investing activities
Net cash used in operating activities

-

-

-

-

-

-

-

-

-

-

-

-

-24,708

-

-20,334

-20,894

-23,165

-20,375

-25,330

-28,099

-20,225

-12,767

-16,229

-11,882

-10,569

Purchases of property and equipment

10

50

107

0

49

1,093

491

397

382

-

-

-

-

25

0

6

39

505

137

596

178

99

2,286

324

125

Proceeds from maturities of investments

47,413

54,691

83,943

58,478

60,033

43,132

43,776

23,000

27,602

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Purchases of investments

93,882

88,160

43,661

18,675

27,993

145,149

22,719

50,207

24,736

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Net cash (used in) provided by investing activities

-46,479

-33,519

40,175

39,803

31,991

-103,110

20,566

-27,604

2,484

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Financing activities
Increase in restricted cash

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

0

0

0

400

Proceeds from maturities of investments

-

-

-

-

-

-

-

-

-

-

-

-

25,624

-

30,673

44,253

65,793

77,063

97,735

26,069

15,000

-

-

-

-

Purchases of investments

-

-

-

-

-

-

-

-

-

-

-

-

25,075

-

35,648

28,030

59,003

42,718

52,957

24,615

184,902

-

-

-

-

Net cash provided by investing activities

-

-

-

-

-

-

-

-

-

-

-

-

549

-

-4,975

16,217

6,751

33,843

44,556

858

-170,080

-63,896

-2,286

-324

-525

Proceeds from the exercise of stock options

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

196

-

-

-

-

-

-

-

-

Proceeds from issuance of common stock, net of issuance costs

162,096

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1,254

0

-160

90,990

-

-

-

-

Proceeds from the exercise of stock options and shares issued under employee stock purchase plan

2,733

3,381

577

395

152

892

786

1,412

429

395

160

246

57

-

-

-

-

230

39

177

170

149

75

47

13

Net cash provided by financing activities

164,829

34,936

88,822

395

152

167,776

772

147,132

429

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Net cash provided by financing activities

-

-

-

-

-

-

-

-

-

-

-

-

57

-

31,479

240

196

1,484

39

17

91,160

149

113,339

-380

13

Effect of exchange rate on cash, cash equivalents and restricted cash

-80

45

-35

46

-37

-69

35

-87

43

30

70

95

16

-101

21

-34

48

-93

3

2

-11

-

-

-

-

Net increase (decrease) in cash, cash equivalents and restricted cash

73,259

-38,027

92,456

-7,960

-34,517

16,425

-17,292

81,813

-31,696

14,548

-926

29,809

-24,086

5,752

6,191

-4,471

-16,170

14,859

19,268

-27,222

-99,156

-76,522

94,824

-12,586

-11,081

Supplemental disclosures:
Operating lease right-of-use assets obtained in exchange for operating lease liabilities

-

0

0

0

11,711

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Property and equipment purchases included in accounts payable

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

453

-434

486

-

-

-

-

Vesting of restricted common stock

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

27

41

43

208

20

76

1

Deferred financing costs in accrued expenses

294

-

-

-

-

-

-

-

-

-

-

-

15

-

-

-

-

-

-

-

160

-

-

-

-

Cash paid for amounts included in the measurement of operating lease liabilities

796

793

777

689

630

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Cash paid for interest on deferred royalty obligation

1,240

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-