| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|
Revenues: | ||||||||
Total revenues | ||||||||
40,893 | 30,336 | 1,605 | 154 | 250 | - | - | - | - |
Contract and grant revenue | ||||||||
- | - | - | - | - | 229 | 387 | 634 | 152 |
Operating expenses: | ||||||||
Cost of sales | ||||||||
2,407 | - | - | - | - | - | - | - | - |
Research and development | ||||||||
122,340 | 161,372 | 107,273 | 86,938 | 97,744 | 60,127 | 28,452 | 14,095 | 8,623 |
Selling, general and administrative | ||||||||
105,421 | 48,847 | 24,870 | - | - | - | - | - | - |
General and administrative | ||||||||
- | - | - | 23,948 | 21,582 | 15,948 | 5,885 | 2,429 | 1,840 |
Total operating expenses | ||||||||
230,168 | 210,219 | 132,143 | 110,886 | 119,326 | 76,075 | 34,337 | 16,524 | 10,463 |
Loss from operations | ||||||||
-189,275 | -179,883 | -130,538 | -110,732 | -119,076 | -75,846 | -33,950 | -15,890 | -10,311 |
Other income (expense): | ||||||||
Interest income | ||||||||
5,422 | 4,028 | 1,698 | 1,284 | 897 | 97 | 3 | 2 | - |
Interest expense | ||||||||
15,647 | 2,493 | - | - | - | 1 | - | - | - |
Other income (expense), net | ||||||||
-50 | -33 | -81 | 10 | -2 | -27 | - | 2 | - |
Total other expense, net | ||||||||
-10,275 | 1,502 | 1,617 | 1,294 | 895 | 69 | 3 | - | - |
Loss before income taxes | ||||||||
-199,550 | -178,381 | -128,921 | -109,438 | -118,181 | -75,777 | - | - | - |
Income tax provision | ||||||||
40 | 26 | 63 | 139 | - | - | - | - | - |
Net loss | ||||||||
-199,590 | -178,407 | -128,984 | -109,577 | -118,181 | -75,777 | -33,947 | -15,888 | -10,311 |
Net loss per share—basic and diluted | ||||||||
-3.22 | -3.14 | -2.81 | -2.92 | -3.32 | -2.43 | -5.59 | -8.95 | -10.27 |
Weighted-average number of common shares outstanding used in net loss per share—basic and diluted | ||||||||
61,955 | 56,799 | 45,899 | 37,523 | 35,619 | 31,135 | 6,067 | 1,775 | 1,004 |
Product revenue | ||||||||
Total revenues | ||||||||
30,540 | - | - | - | - | - | - | - | - |
License and other revenue | ||||||||
Total revenues | ||||||||
10,353 | 30,336 | 1,605 | - | - | - | - | - | - |