| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 |
|---|---|---|---|---|---|---|---|---|---|
Operating Activities | |||||||||
Net loss | |||||||||
-63,140 | -60,447 | -35,434 | -27,560 | -22,625 | -30 | -28 | -27 | -27 | -22 |
Adjustments to reconcile net loss to net cash used in operating activities: | |||||||||
Share-based compensation expense | |||||||||
9,409 | 8,654 | 4,545 | 2,089 | 2,259 | - | - | - | - | - |
Non-cash interest expense | |||||||||
- | 184 | 118 | 42 | 37 | - | - | - | - | - |
Loss on debt extinguishment | |||||||||
- | -498 | - | - | - | - | - | - | - | - |
Non-cash license fee expense | |||||||||
- | - | - | - | 500 | - | - | - | - | - |
Change in value of derivative liability | |||||||||
- | - | - | - | -268 | - | - | - | - | - |
Non-cash interest expense, related party | |||||||||
- | - | - | - | 42 | - | - | - | - | - |
Depreciation expense | |||||||||
0 | 10 | 30 | 31 | 20 | - | - | - | - | - |
Amortization of premium and accretion of discount on marketable securities, net | |||||||||
1,103 | 1,935 | 260 | -129 | -171 | - | - | - | - | - |
Changes in operating assets and liabilities: | |||||||||
Accounts receivable, related party | |||||||||
-210 | 8 | -79 | -135 | 400 | - | - | - | - | - |
Prepaid expenses and other current assets | |||||||||
1,085 | 457 | 196 | 32 | 650 | - | - | - | - | - |
Other long-term assets | |||||||||
117 | 504 | 593 | 652 | 164 | - | - | - | - | - |
Accounts payable and accrued expenses | |||||||||
856 | 5,116 | 3,052 | 471 | 2,812 | - | - | - | - | - |
Prepaid expenses | |||||||||
- | - | - | - | - | -2 | -1 | 1 | 0 | 0 |
Accounts payable and accrued expenses, related party | |||||||||
- | - | - | -167 | 803 | - | - | - | - | - |
Other long-term liabilities | |||||||||
210 | 234 | 218 | 165 | -998 | - | - | - | - | - |
Proceeds from issuance of convertible notes | |||||||||
- | - | - | - | 4,290 | - | - | - | - | - |
Increase (decrease) in accounts payable | |||||||||
- | - | - | - | - | 2 | -1 | -1 | 0 | 1 |
Increase in accrued interest | |||||||||
- | - | - | - | - | 6 | 5 | 4 | 3 | 1 |
Increase in accrued expenses | |||||||||
- | - | - | - | - | 3 | 0 | 0 | 0 | 0 |
Net cash used in operating activities | |||||||||
-54,760 | -48,655 | -28,441 | - | - | -15 | -23 | -24 | -22 | -19 |
Net cash used in operating activities | |||||||||
- | - | - | -25,349 | -17,925 | - | - | - | - | - |
Investing Activities | |||||||||
Maturities and sales of marketable securities | |||||||||
181,246 | 158,143 | 77,217 | 68,605 | 6,000 | - | - | - | - | - |
Purchases of marketable securities | |||||||||
227,571 | 237,443 | 100,635 | 56,427 | 76,562 | - | - | - | - | - |
Purchases of property and equipment | |||||||||
- | - | - | - | 64 | - | - | - | - | - |
Net cash provided by investing activities | |||||||||
-46,325 | -79,300 | -23,418 | 12,178 | -70,626 | - | - | - | - | - |
Financing Activities | |||||||||
Payments on notes payable, stockholders | |||||||||
- | - | - | - | - | 0 | 0 | 0 | 0 | 0 |
Proceeds from issuances of common stock, net | |||||||||
108,165 | 132,172 | 53,679 | - | 97,870 | 0 | 0 | 0 | 0 | 0 |
Proceeds from exercise of stock options and purchases under employee stock purchase plan | |||||||||
2,936 | 1,092 | 232 | - | - | - | - | - | - | - |
Proceeds from issuance of long-term debt, net | |||||||||
- | 627 | - | 7,453 | - | - | - | - | - | - |
Repayment of long-term debt | |||||||||
- | 1,250 | - | - | - | - | - | - | - | - |
Payment of fee related to long-term debt | |||||||||
- | - | 344 | - | - | - | - | - | - | - |
Proceeds from issuance of convertible notes, related party | |||||||||
- | - | - | - | 710 | 15 | 25 | 25 | 0 | 35 |
Net cash provided by financing activities | |||||||||
- | - | - | 7,453 | 102,870 | - | - | - | - | - |
Net cash provided by financing activities | |||||||||
111,101 | 132,641 | 53,567 | - | - | 15 | 25 | 25 | 0 | 35 |
Net increase in cash, cash equivalents and restricted cash | |||||||||
10,016 | 4,686 | 1,708 | -5,718 | 14,319 | -0 | 1 | 0 | -22 | 15 |
Supplemental disclosure of cash flow information: | |||||||||
Interest paid | |||||||||
430 | 641 | 627 | 352 | - | - | - | - | - | - |
Supplemental non-cash disclosures: | |||||||||
Warrants issued in connection with debt facility | |||||||||
- | - | - | 172 | - | - | - | - | - | - |
Conversion of convertible notes and related accrued interest to common stock | |||||||||
- | - | - | - | 4,327 | - | - | - | - | - |
Conversion of convertible notes and related accrued interest to common stock, related party | |||||||||
- | - | - | - | 3,288 | - | - | - | - | - |