| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 |
|---|---|---|---|---|---|---|---|---|---|
Operating activities | |||||||||
Net Income (Loss) Attributable to Parent | |||||||||
-116,508 | -199,469 | -114,803 | -78,185 | -41,912 | -21,313 | -17,935 | -7,737 | -11,548 | -3,760 |
Adjustments to reconcile net loss to net cash used for operating activities: | |||||||||
Share-based compensation expense | |||||||||
23,733 | 35,151 | 21,795 | 14,546 | 11,551 | 8,992 | 12,373 | 8,604 | 254 | 489 |
Third party share-based compensation expense | |||||||||
- | - | - | - | 1,521 | 63 | 0 | - | - | - |
Issuance of common stock for services | |||||||||
- | - | - | - | - | 25 | 0 | - | - | - |
Gain on adjustment to fair value of derivative liabilities | |||||||||
- | - | - | - | - | - | - | 2,998 | -9,508 | 5,347 |
Depreciation and amortization expense | |||||||||
4,552 | 4,405 | 1,268 | 730 | 347 | 17 | 5 | 0 | - | - |
Loss on disposal of equipment | |||||||||
-24 | -236 | -199 | -75 | -16 | 0 | 0 | - | - | - |
Non-cash interest expense | |||||||||
8,775 | 6,797 | 0 | 0 | - | - | - | - | - | - |
Non-cash rent expense | |||||||||
1,307 | 0 | - | - | - | - | - | - | - | - |
Changes in operating assets and liabilities: | |||||||||
Accounts receivable, net | |||||||||
1,579 | 1,381 | 0 | 0 | - | - | - | - | - | - |
Inventory, net | |||||||||
191 | 2,020 | 0 | 0 | - | - | - | - | - | - |
Restricted cash, current portion | |||||||||
- | - | - | - | 200 | 0 | 37 | - | - | - |
Restricted cash | |||||||||
- | - | - | - | - | - | - | 0 | - | - |
Prepaid clinical expenses | |||||||||
- | - | - | - | - | 1,528 | 0 | - | - | - |
Issuance of Series C-1 Preferred Stock for services | |||||||||
- | - | - | - | - | - | - | - | - | -12 |
(Gain) loss on adjustments to fair value of derivative liabilities | |||||||||
- | - | - | - | - | - | - | - | - | -5,015 |
Prepaid expenses and other current assets | |||||||||
-644 | 1,964 | 1,642 | 664 | -824 | 94 | 18 | -35 | -7 | -519 |
Other assets | |||||||||
- | - | -219 | 149 | 70 | 0 | 0 | - | - | - |
Accounts payable | |||||||||
-4,395 | -2,912 | 4,832 | 3,600 | 2,322 | -104 | 742 | -49 | 31 | -231 |
Accrued expenses | |||||||||
395 | 5,451 | -202 | 227 | -248 | 739 | 80 | - | - | - |
Accrued payroll and related expenses | |||||||||
823 | 2,514 | 2,918 | 987 | 666 | 324 | 56 | 10 | -78 | -88 |
Lease liability | |||||||||
2,530 | 0 | - | - | - | - | - | - | - | - |
Deferred rent | |||||||||
0 | 824 | 335 | 124 | 0 | - | - | - | - | - |
Net cash used for operating activities | |||||||||
-84,950 | -152,368 | -85,081 | -58,709 | -25,183 | -12,879 | -4,734 | -2,135 | -1,826 | -3,391 |
Investing activities | |||||||||
Purchase of property and equipment | |||||||||
698 | 2,340 | 9,194 | 2,218 | 1,816 | 258 | 43 | 0 | - | - |
Net cash provided by (used for) investing activities | |||||||||
-698 | -2,340 | -9,194 | -2,218 | -1,816 | -258 | -43 | 0 | - | - |
Financing activities | |||||||||
Proceeds from the issuance of common stock under ESPP | |||||||||
833 | 391 | 0 | 0 | - | - | - | - | - | - |
Net proceeds from issuance of common stock under 2013 Equity Plan | |||||||||
31 | 1,908 | 2,693 | 149 | 315 | 0 | 0 | - | - | - |
Net proceeds from royalty financing | |||||||||
0 | 124,289 | 0 | 0 | - | - | - | - | - | - |
Net proceeds from the issuance of common stock | |||||||||
0 | 109,809 | 117,480 | 0 | 104,596 | 53,063 | 6,751 | 0 | - | - |
Restricted cash, long term | |||||||||
- | - | - | - | 0 | - | - | - | - | - |
Proceeds from the issuance of Series F Convertible Preferred Stock | |||||||||
- | - | - | - | - | 0 | 3,250 | 0 | - | - |
Exercise of Series C-2 Warrants for Preferred Shares | |||||||||
- | - | - | - | - | - | - | 500 | - | - |
Proceeds from issuance of derivative obligations | |||||||||
- | - | - | - | - | - | - | - | - | 6,003 |
Net cash provided by financing activities | |||||||||
864 | 236,397 | 120,173 | 149 | 104,911 | 53,063 | 10,001 | 500 | - | 6,003 |
Net decrease in cash and restricted cash | |||||||||
-84,784 | 81,689 | 25,898 | -60,778 | - | - | - | - | - | - |
Supplemental disclosure of non-cash investing and financing activities: | |||||||||
Conversion of Series F Convertible Preferred Stock into common stock | |||||||||
2,737 | 0 | - | - | - | - | - | - | - | - |
Initial recognition of right-of-use lease asset | |||||||||
16,798 | - | - | - | - | - | - | - | - | - |
Interest paid | |||||||||
1,999 | 506 | 0 | 0 | - | - | - | - | - | - |
Capitalized landlord funded tenant improvements | |||||||||
- | - | 13,696 | 0 | 0 | - | - | - | - | - |
Reconciliation of cash and restricted cash to the consolidated balance sheets | |||||||||
Reconciliation of cash and restricted cash to the condensed consolidated balance sheets | |||||||||
Net increase (decrease) in cash and cash equivalents | |||||||||
- | - | - | - | 77,912 | 39,926 | 5,224 | -1,635 | -1,826 | 2,612 |
Interest paid | |||||||||
- | - | - | - | - | - | - | - | - | 0 |
Change in par value of capital stock | |||||||||
- | - | - | - | - | - | - | - | - | -938 |
Issuance of common stock at par value, offset by paid-in capital reduction | |||||||||
- | - | - | - | - | - | - | - | - | 290 |
Conversion of temporary equity into common stock | |||||||||
- | - | - | - | - | - | - | 0 | 904 | - |
Reclassification of Preferred Stock Not Currently Redeemable | |||||||||
- | - | - | - | - | - | 4,568 | 0 | - | - |
Proceeds from Issuance of Preferred Stock and Preference Stock | |||||||||
- | - | - | - | - | - | 801 | 780 | - | - |
Conversion of Series C-1 and D-1 Preferred Stock into common stock | |||||||||
- | - | - | - | - | - | - | 47 | 5,531 | - |
Issuance of Series D-1 Preferred Stock | |||||||||
- | - | - | - | - | - | - | 4,631 | - | - |
Reclassification of preferred stock no longer redeemable | |||||||||
- | - | - | - | - | - | - | 5,792 | 58 | 388 |
Preferred stock dividend forfeited (earned) | |||||||||
- | - | - | - | - | - | - | - | - | 466 |
Reclassification of Derivative Liabilities value due to removal of redemption and certain conversion features | |||||||||
- | - | - | - | - | - | - | 12,418 | 17 | - |