| Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities: | ||||||||||||||||||
Net loss | ||||||||||||||||||
-27,064 | -11,726 | -3,558 | -20,628 | -73,319 | -30,401 | -24,528 | -27,194 | -17,691 | -15,916 | -11,597 | -12,867 | -8,771 | -8,056 | -6,182 | -7,122 | -6,743 | -3,905 | -2,902 |
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: | ||||||||||||||||||
Amortization of premium and discounts on investments | ||||||||||||||||||
-757 | -514 | -245 | -62 | 20 | 46 | 76 | 120 | 162 | 139 | 107 | 106 | 132 | 94 | 59 | - | - | - | - |
Depreciation of property and equipment | ||||||||||||||||||
206 | 106 | 80 | 45 | 32 | 27 | 21 | 33 | 16 | 14 | 14 | 6 | 7 | 3 | 1 | - | - | - | - |
Stock-based compensation | ||||||||||||||||||
11,153 | 12,346 | 9,651 | 4,745 | 5,267 | 5,436 | 3,974 | 2,566 | 2,765 | 1,287 | 1,342 | 2,305 | 1,165 | 1,635 | 1,049 | 477 | 2,035 | 473 | 64 |
Changes in operating assets and liabilities: | ||||||||||||||||||
Receivable from collaboration partner | ||||||||||||||||||
0 | -4,529 | -145,471 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Prepaid expenses and other assets | ||||||||||||||||||
596 | -143 | 588 | 981 | 1,177 | -565 | 1,483 | -1,406 | 1,467 | 286 | -571 | 272 | 1,801 | 169 | -271 | - | - | - | 484 |
Accounts payable | ||||||||||||||||||
-2,771 | -1,007 | 1,800 | 2,167 | -346 | 922 | 192 | 40 | 344 | -81 | 489 | -462 | 316 | 130 | 46 | 32 | -369 | 333 | 22 |
Accrued expenses and other current liabilities | ||||||||||||||||||
9,353 | 11,840 | 9 | 6,896 | 6,633 | -147 | -4,928 | 8,450 | 514 | 2,972 | -437 | 476 | 705 | 416 | -524 | - | - | - | - |
Deferred revenue | ||||||||||||||||||
-52,938 | -51,228 | -42,853 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash provided by (used in) operating activities | ||||||||||||||||||
-61,431 | -34,918 | 109,767 | 220,881 | -62,890 | -23,552 | -26,676 | -14,579 | -15,357 | -11,871 | -9,511 | -10,708 | -8,247 | -5,947 | -5,280 | -5,625 | -5,627 | -3,307 | -3,136 |
Accrued expenses | ||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 164 |
Investing activities: | ||||||||||||||||||
Purchases of available-for-sale securities | ||||||||||||||||||
137,956 | 84,254 | 214,383 | 214,814 | 190,986 | 48,436 | 120,272 | 41,698 | 18,920 | 59,173 | 43,499 | 68,157 | 28,897 | 26,401 | 10,275 | - | - | - | - |
Proceeds from maturing available-for-sale securities | ||||||||||||||||||
185,985 | 158,025 | 66,888 | 55,081 | 73,497 | 36,875 | 35,683 | 34,677 | 32,941 | 37,552 | 31,868 | 41,326 | 34,920 | 31,500 | 8,900 | - | - | - | - |
Purchase of property and equipment | ||||||||||||||||||
1,126 | 1,861 | 746 | 391 | 234 | 63 | 101 | 12 | -6 | 2 | 229 | 20 | 2 | 51 | 20 | - | - | - | - |
Net cash used in investing activities | ||||||||||||||||||
46,903 | 71,910 | -148,241 | -160,124 | -117,723 | -11,624 | -84,690 | -7,033 | 14,027 | -21,623 | -11,860 | -26,851 | 6,021 | 5,048 | -1,395 | - | - | - | - |
Financing activities: | ||||||||||||||||||
Proceeds from issuance of redeemable convertible preferred stock, net | ||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | -45 | 28,223 | 15,000 |
Proceeds from issuance of common stock, net | ||||||||||||||||||
- | - | - | 0 | 30 | 245,891 | 129,386 | - | - | - | - | - | - | - | - | - | - | - | - |
Proceeds from the exercise of stock options | ||||||||||||||||||
2,988 | 6,879 | 229 | 533 | 735 | 1,372 | 100 | 59 | 353 | 120 | 741 | - | - | - | - | 0 | 8 | 84 | 75 |
Net cash provided by financing activities | ||||||||||||||||||
2,988 | 6,879 | 229 | 533 | 765 | 247,263 | 129,486 | 59 | 353 | 38,853 | 741 | - | - | - | - | 0 | 72,951 | 27,685 | 15,075 |
Net (decrease) increase in cash, cash equivalents, and restricted cash | ||||||||||||||||||
-11,540 | 43,871 | -38,245 | 61,290 | -179,848 | 212,087 | 18,120 | -21,553 | -977 | 5,359 | -20,630 | 33,768 | -2,226 | -620 | -6,675 | -74,691 | 67,317 | 24,371 | 11,939 |
Unrealized gain on available for sale securities | ||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | 21 | - | - | - | - |
Accretion of redeemable convertible preferred stock | ||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 11 |