| Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities: | ||||||||||||||||||
Net loss | ||||||||||||||||||
-62,976 | -109,231 | -127,906 | -148,876 | -155,442 | -99,814 | -85,329 | -72,398 | -58,071 | -49,151 | -41,291 | -35,876 | -30,131 | -28,103 | -23,952 | -20,672 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: | ||||||||||||||||||
Amortization of premium and discounts on investments | ||||||||||||||||||
-1,578 | -801 | -241 | 80 | 262 | 404 | 497 | 528 | 514 | 484 | 439 | 391 | 0 | 0 | 0 | - | - | - | - |
Depreciation of property and equipment | ||||||||||||||||||
437 | 263 | 184 | 125 | 113 | 97 | 84 | 77 | 50 | 41 | 30 | 17 | 0 | 0 | 0 | - | - | - | - |
Stock-based compensation | ||||||||||||||||||
37,895 | 32,009 | 25,099 | 19,422 | 17,243 | 14,741 | 10,592 | 7,960 | 7,699 | 6,099 | 6,447 | 6,154 | 4,326 | 5,196 | 4,034 | 3,049 | 0 | 0 | 0 |
Changes in operating assets and liabilities: | ||||||||||||||||||
Receivable from collaboration partner | ||||||||||||||||||
0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Prepaid expenses and other assets | ||||||||||||||||||
2,022 | 2,603 | 2,181 | 3,076 | 689 | 979 | 1,830 | -224 | 1,454 | 1,788 | 1,671 | 1,971 | 0 | 0 | 0 | - | - | - | 0 |
Accounts payable | ||||||||||||||||||
189 | 2,614 | 4,543 | 2,935 | 808 | 1,498 | 495 | 792 | 290 | 262 | 473 | 30 | 524 | -161 | 42 | 18 | 0 | 0 | 0 |
Accrued expenses and other current liabilities | ||||||||||||||||||
28,098 | 25,378 | 13,391 | 8,454 | 10,008 | 3,889 | 7,008 | 11,499 | 3,525 | 3,716 | 1,160 | 1,073 | 0 | 0 | 0 | - | - | - | - |
Deferred revenue | ||||||||||||||||||
0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash provided by (used in) operating activities | ||||||||||||||||||
234,299 | 232,840 | 244,206 | 107,763 | -127,697 | -80,164 | -68,483 | -51,318 | -47,447 | -40,337 | -34,413 | -30,182 | -25,099 | -22,479 | -19,839 | -17,695 | 0 | 0 | 0 |
Accrued expenses | ||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 |
Investing activities: | ||||||||||||||||||
Purchases of available-for-sale securities | ||||||||||||||||||
651,407 | 704,437 | 668,619 | 574,508 | 401,392 | 229,326 | 240,063 | 163,290 | 189,749 | 199,726 | 166,954 | 133,730 | 0 | 0 | 0 | - | - | - | - |
Proceeds from maturing available-for-sale securities | ||||||||||||||||||
465,979 | 353,491 | 232,341 | 201,136 | 180,732 | 140,176 | 140,853 | 137,038 | 143,687 | 145,666 | 139,614 | 116,646 | 0 | 0 | 0 | - | - | - | - |
Purchase of property and equipment | ||||||||||||||||||
4,124 | 3,232 | 1,434 | 789 | 410 | 170 | 109 | 237 | 245 | 253 | 302 | 93 | 0 | 0 | 0 | - | - | - | - |
Net cash used in investing activities | ||||||||||||||||||
-189,552 | -354,178 | -437,712 | -374,161 | -221,070 | -89,320 | -99,319 | -26,489 | -46,307 | -54,313 | -27,642 | -17,177 | 0 | 0 | 0 | - | - | - | - |
Financing activities: | ||||||||||||||||||
Proceeds from issuance of redeemable convertible preferred stock, net | ||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 43,178 | 0 | 0 | 0 |
Proceeds from issuance of common stock, net | ||||||||||||||||||
- | - | - | 375,307 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Proceeds from the exercise of stock options | ||||||||||||||||||
10,629 | 8,376 | 2,869 | 2,740 | 2,266 | 1,884 | 632 | 1,273 | 0 | 0 | 0 | - | - | - | - | 167 | 0 | 0 | 0 |
Net cash provided by financing activities | ||||||||||||||||||
10,629 | 8,406 | 248,790 | 378,047 | 377,573 | 377,161 | 168,751 | 40,006 | 0 | 0 | 0 | - | - | - | - | 115,711 | 0 | 0 | 0 |
Net (decrease) increase in cash, cash equivalents, and restricted cash | ||||||||||||||||||
55,376 | -112,932 | 55,284 | 111,649 | 28,806 | 207,677 | 949 | -37,801 | 17,520 | 16,271 | 10,292 | 24,247 | -84,212 | -14,669 | 10,322 | 28,936 | 0 | 0 | 0 |
Unrealized gain on available for sale securities | ||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - | - | - | - |
Accretion of redeemable convertible preferred stock | ||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 |