| Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 | Sep'13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Revenue from collaboration agreement | |||||||||||||||||||
42,470 | 42,601 | 38,429 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Operating expenses: | |||||||||||||||||||
Research and development with related party | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 3,900 | 2,874 | 2,919 | 1,918 | 2,163 | 2,413 | 1,717 | 1,275 | 8,149 |
Research and development | |||||||||||||||||||
56,928 | 41,555 | 31,990 | 30,718 | 64,754 | 24,398 | 20,169 | 23,358 | 14,230 | 12,331 | 8,356 | 5,861 | 3,387 | 2,793 | 1,915 | 2,452 | 2,708 | 1,020 | 767 | 37 |
General and administrative | |||||||||||||||||||
15,864 | 15,742 | 12,194 | 12,689 | 9,680 | 6,515 | 4,773 | 4,044 | 3,679 | 3,786 | 3,394 | 3,177 | 2,552 | 2,387 | 2,392 | 2,525 | 1,622 | 1,168 | 860 | 159 |
Total operating expenses | |||||||||||||||||||
72,792 | 57,297 | 44,184 | 43,407 | 74,434 | 30,913 | 24,942 | - | - | - | - | - | - | - | - | - | - | - | - | - |
Loss from operations | |||||||||||||||||||
-30,322 | -14,696 | -5,755 | -22,107 | -74,434 | -30,913 | -24,942 | -27,402 | -17,909 | -16,117 | -11,750 | -12,938 | -8,813 | -8,099 | -6,225 | -7,140 | -6,743 | -3,905 | -2,902 | - |
Interest income, net | |||||||||||||||||||
3,258 | 2,970 | 2,197 | 1,479 | 1,115 | 512 | 414 | 208 | 218 | 201 | 153 | 71 | 42 | 43 | 43 | - | - | - | - | - |
Net loss | |||||||||||||||||||
-27,064 | -11,726 | -3,558 | -20,628 | -73,319 | -30,401 | -24,528 | -27,194 | -17,691 | -15,916 | -11,597 | -12,867 | -8,771 | -8,056 | -6,182 | -7,122 | -6,743 | -3,905 | -2,902 | -8,345 |
Accretion of redeemable convertible preferred stock | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 6 | 17 | 11 | - |
Net loss attributable to common stockholders | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -7,122 | -6,749 | -3,922 | -2,913 | -8,345 |
Per share information: | |||||||||||||||||||
Net loss per share of common stock, basic and diluted (in dollars per share) | |||||||||||||||||||
-0.89 | -0.39 | -0.12 | -0.76 | -2.45 | -1.14 | -0.96 | -1.28 | -0.82 | -0.77 | -0.59 | -0.72 | -0.53 | -0.49 | -0.38 | 26.30 | -0.68 | -14.46 | -14.22 | -45.20 |
Weighted average shares outstanding, basic and diluted diluted (in shares) | |||||||||||||||||||
30,502 | 30,156 | 30,025 | 30,015 | 29,872 | 26,586 | 25,668 | 21,879 | 21,609 | 20,587 | 19,544 | 18,002 | 16,560 | 16,540 | 16,474 | 16,671 | 9,947 | 271 | 204 | 184 |