| Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 | Sep'13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Revenue from collaboration agreement | |||||||||||||||||||
0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Operating expenses: | |||||||||||||||||||
Research and development with related party | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 11,611 | 9,874 | 9,413 | 8,211 | 7,568 | 13,554 | 0 | 0 | 0 |
Research and development | |||||||||||||||||||
161,191 | 169,017 | 151,860 | 140,039 | 132,679 | 82,155 | 70,088 | 58,275 | 40,778 | 29,935 | 20,397 | 13,956 | 10,547 | 9,868 | 8,095 | 6,947 | 4,532 | 0 | 0 | 0 |
General and administrative | |||||||||||||||||||
56,489 | 50,305 | 41,078 | 33,657 | 25,012 | 19,011 | 16,282 | 14,903 | 14,036 | 12,909 | 11,510 | 10,508 | 9,856 | 8,926 | 7,707 | 6,175 | 3,809 | 0 | 0 | 0 |
Total operating expenses | |||||||||||||||||||
217,680 | 219,322 | 192,938 | 173,696 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - |
Loss from operations | |||||||||||||||||||
-72,880 | -116,992 | -133,209 | -152,396 | -157,691 | -101,166 | -86,370 | -73,178 | -58,714 | -49,618 | -41,600 | -36,075 | -30,277 | -28,207 | -24,013 | -20,690 | 0 | 0 | 0 | - |
Interest income, net | |||||||||||||||||||
9,904 | 7,761 | 5,303 | 3,520 | 2,249 | 1,352 | 1,041 | 780 | 643 | 467 | 309 | 199 | 0 | 0 | 0 | - | - | - | - | - |
Net loss | |||||||||||||||||||
-62,976 | -109,231 | -127,906 | -148,876 | -155,442 | -99,814 | -85,329 | -72,398 | -58,071 | -49,151 | -41,291 | -35,876 | -30,131 | -28,103 | -23,952 | -20,672 | -21,895 | 0 | 0 | 0 |
Accretion of redeemable convertible preferred stock | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 34 | 0 | 0 | 0 | - |
Net loss attributable to common stockholders | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -20,706 | -21,929 | 0 | 0 | 0 |
Per share information: | |||||||||||||||||||
Net loss per share of common stock, basic and diluted (in dollars per share) | |||||||||||||||||||
-0.89 | -0.39 | -0.12 | -0.76 | -2.45 | -1.14 | -0.96 | -1.28 | -0.82 | -0.77 | -0.59 | -0.72 | -0.53 | -0.49 | -0.38 | 26.30 | -0.68 | -14.46 | -14.22 | -45.20 |
Weighted average shares outstanding, basic and diluted diluted (in shares) | |||||||||||||||||||
30,502 | 30,156 | 30,025 | 30,015 | 29,872 | 26,586 | 25,668 | 21,879 | 21,609 | 20,587 | 19,544 | 18,002 | 16,560 | 16,540 | 16,474 | 16,671 | 9,947 | 271 | 204 | 184 |