| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||||||
Net loss | ||||||||||
-83,948 | -32,811 | -31,154 | -26,388 | -68,671 | -86,161 | -90,192 | -62,790 | -47,380 | -37,467 | 79,088 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||
PIK interest expense on convertible promissory notes payable - related parties | ||||||||||
- | - | - | 1,207 | - | - | - | - | - | - | - |
Stock-based compensation expense | ||||||||||
22,759 | 13,489 | 3,254 | 7,929 | 4,300 | 7,431 | 6,030 | 3,322 | 3,354 | 4,048 | 4,579 |
Other share based compensation | ||||||||||
- | - | - | 750 | - | - | - | - | - | - | - |
Depreciation and amortization expense | ||||||||||
112 | 96 | 77 | - | 662 | 673 | 516 | 738 | 1,464 | 1,933 | 2,463 |
Changes in operating assets and liabilities: | ||||||||||
Accounts receivable - related parties | ||||||||||
- | - | - | -7 | - | - | - | - | - | - | - |
Collaboration receivable | ||||||||||
- | - | - | - | - | - | - | - | -116 | 116 | -16,000 |
Restricted cash | ||||||||||
- | - | - | - | - | - | - | - | - | - | -151 |
Prepaid expenses and other current assets | ||||||||||
-332 | 998 | -502 | -1,290 | -455 | -102 | -21 | 225 | 130 | 12 | -1,088 |
Other assets | ||||||||||
- | - | - | - | -305 | -111 | 951 | -173 | 265 | 8 | 255 |
Accounts payable | ||||||||||
-1,309 | 558 | 917 | -128 | -1,840 | -3,450 | 928 | 2,194 | 1,542 | -2,032 | 626 |
Accrued expense | ||||||||||
16,783 | -2,168 | 4,087 | -2,281 | - | - | - | - | - | - | - |
Accrued interest, net of interest received on maturity of investments | ||||||||||
3,647 | -3,673 | - | - | - | - | - | - | - | - | - |
Accrued interest - related party | ||||||||||
- | - | - | 6 | - | - | - | - | - | - | - |
Net cash used in operating activities | ||||||||||
-41,624 | -25,507 | -22,317 | -17,608 | -71,444 | -78,925 | -77,411 | -54,135 | -47,300 | -38,199 | -26,810 |
Cash flows from investing activities: | ||||||||||
Accrued contract research costs | ||||||||||
- | - | - | - | -5,454 | 1,910 | 5,646 | 1,920 | 330 | 412 | -10,294 |
Other accrued liabilities | ||||||||||
- | - | - | - | -1,201 | 459 | 591 | 533 | 400 | -310 | 1,663 |
Deferred collaboration revenue | ||||||||||
- | - | - | - | - | - | - | - | -6,731 | -4,647 | -115,625 |
Collaboration payable | ||||||||||
- | - | - | - | - | - | - | - | - | - | -6,294 |
Cash received from merger transaction | ||||||||||
- | - | - | 5,849 | - | - | - | - | - | - | - |
Purchases of marketable securities | ||||||||||
619,303 | 614,358 | 70,211 | 10,697 | 117,135 | 93,845 | 114,151 | 50,033 | 50,726 | 36,916 | 39,303 |
Sales and maturities of marketable securities | ||||||||||
650,182 | 234,304 | 48,330 | 26,063 | 137,193 | 85,152 | 90,267 | 40,595 | 60,745 | 17,250 | 60,806 |
Purchases of property and equipment, net of disposals | ||||||||||
172 | 22 | 125 | 3 | 58 | 144 | 769 | 505 | 690 | 136 | 454 |
Net proceeds from the sale of property, equipment and other assets | ||||||||||
- | - | - | 698 | - | - | - | - | - | - | - |
Release of restricted cash | ||||||||||
- | - | - | 83 | - | - | - | - | - | - | - |
Purchase and retirement of common stock from an officer | ||||||||||
- | - | - | - | - | - | - | 32 | - | - | - |
Net cash provided by (used in) investing activities | ||||||||||
30,707 | -380,076 | -22,006 | 21,993 | 20,000 | -8,837 | -24,653 | -9,943 | 9,329 | -19,802 | 21,049 |
Cash flows from financing activities: | ||||||||||
Proceeds from issuances of stock, excluding related parties, net of transaction costs | ||||||||||
- | 311,825 | 173,805 | 5,954 | - | - | - | - | - | - | - |
Proceeds from the sale of related party stock and exercise of common stock options, net of transaction costs | ||||||||||
235 | 2,510 | - | - | 12,700 | 4,992 | 19,437 | 53,545 | 7,734 | 8,460 | - |
Proceeds from issuance of common stock, net of transaction costs | ||||||||||
- | - | - | - | 36,942 | 89,796 | 38,735 | 66,248 | 27,581 | 23,530 | - |
Proceeds from convertible notes - related parties | ||||||||||
- | - | - | 8,500 | - | - | - | - | - | - | - |
Proceeds from issuance of common stock, excluding to related parties, and exercise of common stock options, net of transaction costs | ||||||||||
- | - | - | - | - | - | - | - | - | - | 50 |
Proceeds from term loans | ||||||||||
- | - | - | - | - | - | 13,500 | - | 2,000 | 15,000 | - |
Payment of term loans | ||||||||||
- | - | - | - | 9,214 | 9,450 | 2,617 | 4,234 | 378 | - | - |
Payment of capital lease obligations | ||||||||||
- | - | - | - | 42 | 42 | 13 | 12 | 201 | 1,834 | 2,179 |
Net cash provided by financing activities | ||||||||||
235 | 314,335 | 173,805 | 14,454 | 40,386 | 85,296 | 69,042 | 115,515 | 36,736 | 45,156 | -2,129 |
Net increase (decrease) in cash and cash equivalents | ||||||||||
-10,682 | -91,248 | 129,482 | 18,839 | -11,058 | -2,466 | -33,022 | 51,437 | -1,235 | -12,845 | -7,890 |
Supplemental disclosure of cash flow information: | ||||||||||
Obtaining a right-of-use asset in exchange for a lease liability | ||||||||||
900 | - | - | - | - | - | - | - | - | - | - |
Exchange of related party advances payable for convertible notes | ||||||||||
- | - | - | 500 | - | - | - | - | - | - | - |
Related party debt restructuring | ||||||||||
- | - | - | 13,680 | - | - | - | - | - | - | - |
Purchases of property and equipment in accounts payable or accrued expenses at period end | ||||||||||
897 | - | 250 | - | - | - | - | - | - | - | 58 |
Cash paid for interest | ||||||||||
- | - | - | - | 957 | 1,875 | 2,512 | 1,696 | 1,911 | 578 | 312 |
Assets acquired under capital lease | ||||||||||
- | - | - | - | - | - | 126 | - | - | - | - |